Posted by admin on Aug 31, 2020 in |
Solubility plays a vital role in achieving the therapeutic efficacy of a drug from a dosage form. Advances in molecular screening techniques for identification of potential drug molecules investigated an increased number of new pharmacologically active lipophilic compounds that are poorly water-soluble about 40% of new chemical entities have been discovered as poorly water-soluble. Numbers of technical strategies have been investigated for improving bioavailability like solid dispersions, cyclodextrins, micronization, surfactants, nanoparticles, lipids, permeation enhancers, etc. It is a great task for a pharmaceutical scientists to formulate oral dosage forms of these drug candidates with sufficient bioavailability. Among the various approaches to improve the oral bioavailability of these drug candidates, self-dispersing lipid formu-lations is one of the approaches to improve the bioavailability of lipophilic drugs. Self-dispersing lipid formulations is a very broad area that covers self-emulsifying drug delivery system (SEDDS), Self-micro emulsifying drug delivery system (SMEDDS), Self-nano emulsifying drug delivery system (SNEDDS) as carrier systems that have been...
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Posted by admin on Aug 31, 2020 in |
Diabetes mellitus (DM) is a globally spreading metabolic disorder with a high incidence rate. About 425 million cases took place in 2017 and expected to rise up to 693 million by 2045. In diabetes, the patient elevation of blood glucose level occurs due to the deformation of insulin receptor action/secretion or both. Long term increases in blood glucose level causes chronic effects such as dysfunction and damage of various organs such as eyes, nerves, kidney heart and blood vessels. There are many treatment regimens available in market, but do not able to provide complete relief and cause severe side effects. To overcome these types of problems it becomes important to find different therapeutic targets and use it in combination with conventional medicine for the treatment of diabetes. To surmount the side effect of presently available treatments, now researchers relay on herbal plants. In this review, we discussed the diabetes occurrence, epidemiology, types, different target receptors, and available treatments and describe briefly role of different plant constituents in diabetes management...
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Posted by admin on Jul 31, 2020 in |
Diabetes Mellitus is the most common endocrine disorder, affecting a larger population of the world, which arises due to defective insulin secretion by beta cells in the pancreas or insulin resistance by peripheral tissues. As the disease progress, microvascular complications like nephropathy, neuropathy, retinopathy, and cardiovascular complications are observed, which the leading causes of death in diabetic patients. The drug treatment is required when the weight reduction, diet, and modification in lifestyle fails to maintain the normal blood glucose level. Though insulin and oral anti-diabetic drugs are clinically being used; the researchers have been focused on developing still better anti-diabetic drugs. There components like GLP-1, DPP-4, GPR119, GPR 40 and GPR 120, SGLT2, DGAT-1, 11 β-hydroxysteroid dehydrogenase, and Peroxisome proliferator influences/regulate the secretion, release, and uptake of insulin. The study of these targets would help to develop new anti diabetic...
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Posted by admin on Jul 31, 2020 in |
The aim of this review paper is to provide throughout the information of Manilkara hexandra (Roxb.) Dubard, used as a Khirni or Rayon in most of the tropical regions of India. It is native to India, mainly distributed as a wild tree in the southern part and North-central part of India. It is widely spread in Gujarat, Rajasthan, Madhya Pradesh, Andhra Pradesh, Kerala and Maharashtra our efforts are to collect valuable information with respect to morphology, microscopy, phytoconstituents and pharmacological aspect of the plant. The plant contains major phytoconstituents such as protobassic acid, 16-ahydroxyprotobassic acid, taraxerol, a triterpene ketone, alpha and beta-amyrin, cinnamates, alpha-sipnasterol, beta-sitosterol, its beta-D-glucoside, quercitol, quercetin and its dihydroderivatives, ursolic acid. Traditionally, the whole plant is employed as astringent, refrigerant, aphrodisiac, alexipharmic, stomachic, anthelmintic, for reliving fever, flatulence, colic, dyspepsia, helminthiasis, hyperdipsia, burning sensation. All these compounds claimed to possess various pharmacological properties such as antioxidant, antiulcer, anti-inflammatory, antidiuretic and so...
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Posted by admin on Jul 31, 2020 in |
Effective delivery of drugs can be made through various routes of administration, and the oral route is considered to be the most convenient for the administration of drugs to patients. Poor aqueous solubility was acknowledged as the main reason for the poor oral absorption of chemical entities. Apart from the conventional solubilization approaches like co-solvency, salt formation, solid dispersion, more recently self-emulsifying drug delivery systems (SEDDS) have been studied in improving the solubility and dissolution rate of poorly water-soluble and lipophilic drugs. SEDDS can be administered orally in soft or hard gelatin capsules or by converting them into tablets using different techniques like adsorption, melt granulation/extrusion and spray drying for improved stability and ease of...
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