Posted by admin on Aug 31, 2020 in |
Arylpropionic acid derivatives are an important class of NSAIDs. Ibuprofen, 2- (4-isobutylphenyl) propionic acid, is known as NSAIDs. Arylpropionic acid derivatives have a broad biological activity, including antibacterial, anticonvulsant and anticancer activity, analgesic, and anti-inflammatory. In addition to the most powerful ingredients used in analgesic and antipyretic fields, such as ibuprofen, Oxaprozin, Ketoprofen, and Phenoprofen, aryl propionic acid derivatives play an important role in treating other symptoms. The possible improvements in the activity can be further achieved by slight modifications in the substituent on the basic aryl propionic acid. According to Grigoryan et al., 2019 studies reveal that the replacement of the carboxyl group by tetrazole ring, hydroxamate, ester, alcohol, and amide groups forms compound showing lower activity (anti-inflammatory, anti-nociceptive, ulcerogenic activity). The presence of a carboxyl group in the parent molecule of aryl propionic acid is important for broad-spectrum pharmacological activity. This review focused on recent advances and recent research on aryl propionic acid derivatives compared to medicinal...
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Posted by admin on Aug 31, 2020 in |
The late December of 2019 witnessed an outbreak of viral pneumonia of unknown etiology (VPUE) in the Wuhan city of Hubei province, China. Later it was identified as a novel strain of β-genus Coronavirus, which is similar to the Severe Acute Respiratory Syndrome (SARS) virus, which was a global pandemic during 2002-03. This novel coronavirus is rapidly spreading with an R0 of 2 and has an incubation period of 2-14 days. It spreads through human-to-human transmission and by fomites (articles and surfaces contaminated by affected persons). The World Health Organization acted immediately to prevent the spread of the virus by declaring it as a Public Health Emergency of International Concern (PHEIC). It has been declared as a pandemic, and several sets of guidelines have been issued by WHO, including social distancing norms and hygiene practices yet, this novel coronavirus continues to spread at an alarming rate leading to many fatalities across the globe. Since this novel coronavirus shares similar characteristics with other coronaviruses, some of the known treatment options...
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Posted by admin on Aug 31, 2020 in |
Trandermal drug delivery systems are potential sources of administrating drugs through and have certain advantages as delivering a therapeutically effective amount of drug across a patient’s skin. Medicated Tattoos is one of the upcoming approaches in transdermal drug delivery. Researches reveal that humans from the generations have used tattoos for various reasons like symbol of rank, religious/spiritual devotion, and decoration for bravery, sexual temptation as well as to express the love. In the past years, there are various reported cases of syphilis, tetanus, tuberculosis, and herpes that have been associated with tattooing. Many of these infections resulted from mixing saliva with ink or tattooists holding needles in their mouths. Medicated tattoos are becoming a very popular drug delivery system, as tattoos are trendy among adolescents. There are so many recent advancements in the field of medicated tattoos. Recently, the tattooing has been widely used as a drug delivery system in the field of medicine (corneal tattooing, gastrointestinal tattooing during endoscopy, permanent make-up tattooing, scar camouflage, or radiotherapy field was...
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Posted by admin on Aug 31, 2020 in |
Solubility plays a vital role in achieving the therapeutic efficacy of a drug from a dosage form. Advances in molecular screening techniques for identification of potential drug molecules investigated an increased number of new pharmacologically active lipophilic compounds that are poorly water-soluble about 40% of new chemical entities have been discovered as poorly water-soluble. Numbers of technical strategies have been investigated for improving bioavailability like solid dispersions, cyclodextrins, micronization, surfactants, nanoparticles, lipids, permeation enhancers, etc. It is a great task for a pharmaceutical scientists to formulate oral dosage forms of these drug candidates with sufficient bioavailability. Among the various approaches to improve the oral bioavailability of these drug candidates, self-dispersing lipid formu-lations is one of the approaches to improve the bioavailability of lipophilic drugs. Self-dispersing lipid formulations is a very broad area that covers self-emulsifying drug delivery system (SEDDS), Self-micro emulsifying drug delivery system (SMEDDS), Self-nano emulsifying drug delivery system (SNEDDS) as carrier systems that have been...
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Posted by admin on Aug 31, 2020 in |
Diabetes mellitus (DM) is a globally spreading metabolic disorder with a high incidence rate. About 425 million cases took place in 2017 and expected to rise up to 693 million by 2045. In diabetes, the patient elevation of blood glucose level occurs due to the deformation of insulin receptor action/secretion or both. Long term increases in blood glucose level causes chronic effects such as dysfunction and damage of various organs such as eyes, nerves, kidney heart and blood vessels. There are many treatment regimens available in market, but do not able to provide complete relief and cause severe side effects. To overcome these types of problems it becomes important to find different therapeutic targets and use it in combination with conventional medicine for the treatment of diabetes. To surmount the side effect of presently available treatments, now researchers relay on herbal plants. In this review, we discussed the diabetes occurrence, epidemiology, types, different target receptors, and available treatments and describe briefly role of different plant constituents in diabetes management...
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