Posted by admin on Mar 31, 2020 in |
In targeted drug delivery systems, there is one of the most important drug delivery systems is colon targeting drug delivery system. This system is mainly used in the treatment of diseases like colonic cancer, ulcerative colitis, Crohn’s disease. For local treatment of various bowel diseases colon is highly desirable. For the systemic action of nonpeptide drugs i.e., cardiovascular and antiasthmatic agents and protein-peptide drugs such as insulin, calcitonin, colon targeting is apparently useful. There are various approaches that have been proposed for targeted colon delivery; they include the pH, pressure controlled, time-controlled, microflora, osmotic controlled, and multi-particulates and novel techniques. The carriers used in this system are microsphere, synthetic polymers, liposomes and nanoparticles, matrix tablets and compression coated tablets...
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Posted by admin on Mar 31, 2020 in |
Remarkable pharmacological effects exhibited by Guggulsterone (GS) establish its potential as an effective anticancer agent. GS is widely known for its anti-inflammatory and hypolipidemic activities. At the molecular level, GS is known to modulate the activity of various nuclear receptors, growth factors and transcription factors. However, the complete sequence of the underlying anticancer mechanism of GS is not completely understood. Prostate cancer (PCa) initiation is marked with inflammatory events and disease advances towards castration-resistant prostate cancer (CRPCa) through constitutively activated androgen receptor and hyperactivated survival signaling such as NF-kB; therefore PCa cell lines offer a good model system to study the anticancer activities of GS. Considering the fact that GS is both anti-inflammatory and androgen receptor (AR) antagonist, it can be widely employed to achieve two objectives simultaneously – chemoprevention as well as an anti-cancer agent. Evidence from preclinical trials and prescribed usage in Ayurvedic medicine has promoted the use of guggul as a health supplement. However, the use of GS is not completely free of side effects and...
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Posted by admin on Mar 31, 2020 in |
Nanoemulsion system is a promising vehicle due to the powerful ability to deliver the drug through the skin. Researchers have been conducted to prove its potential for the delivery of the drugs used in many skin disorders. Skin is the largest organ and acts as the first line of defense of our body. After a certain period of time, our skin loses tone and elasticity which is called aging. It is the result of programmed senescence and prolonged environmental injury to the skin. The aim of this review article is to provide information regarding the control of skin aging by the nanoemulsion drug delivery system. Novel carrier systems have a lot of advantages when compared to conventional formulations. There are various approaches to preventing skin aging. The most widely used age combating substances in cosmeceuticals are kinetin, Retinoids, sun filters, herbal ingredients (such as resveratrol, turmeric, and green tea), and antioxidants (such as alpha-tocopherol, ascorbic acid, coenzyme Q10 and lipoic acid). In recent years, these molecules have been formulated...
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Posted by admin on Mar 31, 2020 in |
Antibiotics can no longer be considered as effective methods to treat various diseases. The misuse of these medicines has increased the evolvement of a number of drug-resistant microorganisms which are termed as “Superbugs”. These are most prevalent in developing countries where the abuse of antibiotics is at the peak. Clostridium difficile, Streptococcus pneumoniae, MRSA (Staphylococcus aureus), ESBL (Escherichia coli) and NDM1 –E. coli were some of the top listed superbugs. Different kinds of these superbugs attack many countries; even the United States of America, which is under danger from 14 types of superbugs and has lost less than 14,000 individuals every year form C. difficile alone. An NDM-1 strain bacterium, most dangerous superbug, produces a protein that can able to kill the movement of carbapenem antibiotics, which are used to treat a broad range of infections in Hospitals and health care centers. These superbugs can affect an individual by cold, fever, non-healing factors, and lead to organ failures. International and National Organizations should take serious initiatives to curb this...
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Posted by admin on Mar 31, 2020 in |
Electrospinning is a process wherein polymer fibers are developed on applying high voltage. Its principle is based on charge accumulation on the surface of the polymer solution as a result of high voltage which causes the solution to get ejected out as a thin jet by forming a taylor cone. Nanospider is a modified version of electrospinning developed by Technical University in the year 2003. The idea of generating a technology named nano spider was to produce electrospun fibers around 50-400 nm in diameter from the free liquid surface. This technique is employed in many fields such as tissue engineering, drug delivery, wound healing, enzyme immobilization etc due to its easy maintenance, a requirement of less quantity of raw material and its ease of fabrication. Advancements in technology have increased the need for nanofibers and their products which could not be delivered by the conventional fiber spinning method. This urges the need to develop methods such as nanospider which can generate polymer fibers in high...
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