Posted by admin on Feb 29, 2020 in |
The aim of a pharmaceutical product is to obtain excellent therapeutic and favorable treatment. Controlled drug release coatings have been around for more than 50 years and their performance has increased significantly since the beginning. The main drawbacks of the controlled drug delivery system are its poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, development of multiple drug resistance, and non-specific targeting. To overcome this disadvantage, the researcher focused on controlled drug delivery system Injectable hydrogels. It is an emerging trend in the field of biomaterial drug delivery systems. Injectable Hydrogel overcomes the limitation of a pre-formed hydrogel, as they are injected with minimum invasive procedure into target sites and used for irregularly shaped sites. The recent studies of injectable hydrogels for the drug delivery applications suggested that multi-functional injectable hydrogels are capable of entrapping and systematically delivering the multiple therapeutic agents like drugs and macromolecules. The Injectable hydrogel shows shear thinning property when injected into the body. In this review, various aspects of Injectable hydrogel like introduction, Properties,...
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Posted by admin on Feb 29, 2020 in |
The oral route of drug administration is one of the simplest route of drug administration throughout the world because its patients convenience. The drug administered through orally should possess good aqueous solubility for better oral absorption and thus bioavailability will increase. But it was found that 30-40% of the drug shows low solubility thus bioavailability profile will be affected. Self-emulsifying drug delivery (SEDDS) system is a novel therapeutic drug delivery system of those new drugs whose aqueous solubility is very poor. Thus, by this delivery system the new drugs can be administered to the body via oral route and hence therapeutic effect will be desired appropriately. The most unique feature of this delivery system can form oil in water emulsion when diluted in an aqueous phase. Thus, this delivery system enhances the rate and extent of drug or absorption when given by oral route. The cost of this delivery system is affordable as it can consist natural oil and common excipients. Thus, large scale production is also possible for...
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Posted by admin on Feb 29, 2020 in |
Drug delivery to targeted sites is restricted by various barriers. The conventional drug delivery systems like tablets, capsules, suspensions, emulsions, elixirs, lotions etc. are being encountered with a number of issues such as poor bioavailability, drug shelf life, drug-excipients incompatibilities and patient in compliance. Thus with the advent of novel drug delivery systems such as liposomes; nanoparticles are proving to be a better option nowadays. As evolution in the drug delivery system, a new system with lesser side effects was introduced in 2011 known as Spanlastics. They are elastic, deformable surfactant-based nanovesicles in which an aqueous solute solution is entirely enclosed. They are shown to be chemically more stable. They provide targeting and controlled release of natural pharmaceutical compounds and have improved several drawbacks of the conventional dosage form. The current review emphasizes the utility of spanlastics, mechanism of penetration, different preparation approaches, their evaluation parameters and...
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Posted by admin on Feb 29, 2020 in |
Chromens are oxygen-containing heterocycles, abundantly found in nature in the form of flavone, is flavones, flavanones, catechins, anthocyanins and collectively known as flavonoids and isoflavonoids. Being a polar and ionizable aromatic compound, it improves the pharmacokinetic characteristics of lead molecules. Imidazole derivatives have occupied a unique place in the field of medicinal chemistry. Therefore, the incorporation of the chromen nucleus is an important synthetic strategy in drug discovery. The high therapeutic properties of the chromen related drugs have encouraged the researchers to synthesize new chemotherapeutic agents. A variety of cellular targets are interacting with the derivatives of chromen and that can be responsible for their wide-ranging epileptic activities. The substitution of chromen nucleus is a crucial step in the drug discovery process. In the present review, chromen derivatives having antiepileptic activity is described using a structural substitution pattern. The interest in chromen is ever-growing since they offer a fairly diverse chemical space for exploration of medicinal...
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Posted by admin on Feb 29, 2020 in |
Hollow microballoons (microspheres) are spherical empty particles without core. Microballoons (Hollow microsphere) are a drug delivery system that promises to be a potential approach for gastric retention. Microballoons drug-delivery systems are based on a non-effervescent system containing empty particles of spherical shape without core ideally having a size less than 200 micrometers. Microballoons drug delivery systems have shown to be of better significance in controlling the release rate for drugs having site-specific absorption. The floating microballoons showed gastro retentive controlled release delivery with efficient means of enhancing the bioavailability and promises to be a potential approach for gastric retention. Optimized hollow microspheres will find the central place in novel drug delivery, particularly in safe, targeted and effective in-vivo delivery promises to be a potential approach for gastric retention. They are gastro retentive drug-delivery systems, which provide controlled release properties. The advantages, limitations, methods of preparation of hollow microsphere, applications, polymers used in hollow microspheres, characterizations of microballoons and formulation aspects with various evaluation techniques and marketed products are covered in...
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