Posted by admin on Jan 31, 2020 in |
Blood transfusion is an important part of various treatment protocols. Blood should be transfused with certain precautions like drug because blood and its constituents have the propensity to cause effects like introduction of donor antigens within the recipient, transfusion reactions or exposure to numerous transfusion-transmitted diseases. Thereby, it is important for the clinicians to remember those potential risks to the recipient of blood and blood components as well as donors. Haemovigilance system includes monitoring, identification, reporting, investigation, and analysis of adverse reactions associated with transfusion. The data gained from the investigation and analysis facilitates corrective and preventive action to be taken to attenuate the potential risks related to safety and quality of blood donation and transfusion for donors and patients. Forever the developed countries have taken the lead within the haemovigilance. However, developing Asian countries like India lacks a well-established system for haemovigilance program. In this review we have compiled the various haemovigilance and blood safety studies conducted in India to know the current update of haemovigilance program in...
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Posted by admin on Jan 31, 2020 in |
In aerobic organisms, oxygen is essential for sufficient energy production but self-contradictory, produces chronic toxic stress in cells. So, protective techniques must exist for removal of toxic free radicals which are byproducts of oxygen. Diverse protective systems have evolved to enable adaptation of antioxidant activity. Tissues and organs have different rates of metabolic activity and oxygen consumption. Their levels of antioxidants are also different. Such is the case with glutathione (GSH) and cysteine, which are lower in the brain than the liver, kidney, or muscle. Investigations of oxidative responses in different complex organisms such as mammals, organs, and tissues which contain distinct antioxidant systems and this may form the basis for differential susceptibility to toxic agents. Notable advances have been made in our understanding of these distinct systems, with several antioxidant systems and their regulatory pathways being described at the cellular level, thus understanding the pathways leading to the induction of antioxidant responses will enable development of strategies to protect against oxidative...
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Posted by admin on Jan 31, 2020 in |
Coenzyme Q10 (ubiquinone) is a lipophilic benzoquinone substance. It is a pivotal component to the oxidative phosphorylation in the inner mitochondrial membrane of all aerobic cells as well as diminishes reactive oxygen species (ROS). Exogenous sources for CoQ10 are grapes seed oil, walnuts, pistachios, spinach, and sesame seed. At present, it is being utilized as an antioxidant agent. Recent studies have revealed its neuroprotective action. In the present review, the comprehensive pharmacological benefits of coenzyme Q10 on the central nervous system (CNS) has been revealed. Many studies were taken into considerations and compiled in accordance with their activities. Amongst those, the study using in-vitro models referring to neuronal toxicity and animal models of neurodegenerative diseases have been covered. Multiple outcomes have now evolved assisting the role of reactive oxygen species and neuroinflammation in the pathogenesis of the neurodegenerative disorder. The drug coenzyme Q10 has been administered in a human subject with reference to their age and body weight. In case of increased oxidative stress and few selective cases of...
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Posted by admin on Jan 31, 2020 in |
Plants are a valuable source of secondary metabolites. Many phytochemicals are obtained from the plant sources that are used as valuable medicinal agents. Chalcones are one of the important secondary metabolites obtained from many edible plants like foods, vegetables, tea, spices and natural foodstuffs. Chalcones considered as obligate intermediated in flavonoid biosynthesis but they do not accumulate to an appreciable degree in most plants. Chalcones are a group of plant-derived polyphenolic compounds belonging to the flavonoids family that possess a wide variety of cytoprotective and modulatory functions, which may have therapeutic potential for multiple diseases. The largest number of natural chalcones has been isolated from species of the Leguminosae, Asteraceae and Moraceae families. Chalcone accumulating plants have often been used in traditional medicine and These chalcones and their derivatives have shown important antimicrobial, antifungal, anti-mycobacterial, antimalarial, antiviral, anti-inflammatory, antioxidant, anti-tumor, antileishmanial, anticancer properties. The purpose of this review is to summarize the various naturally occurring chalcone compounds which have been isolated from different plants and to describe the recent...
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Posted by admin on Jan 31, 2020 in |
Capillary Electrophoresis–Mass Spectroscopy (CE-MS) is a hyphenated technique as it combines the advantages of both CE and MS. It provides high-resolution separations with high detection selectivity and sensitivity, which allows detailed characterization of many biomolecules in a single analysis. CE-MS improves the ability to deal with the analysis of complex biological samples containing trace amounts of analytes. CE coupled MS has become a widely used analytical technique in fields such as proteomics, metabolomics, and genomics. It is also increasingly used in various other fields like environmental science, food analysis, biotechnology and forensic science etc. However, the development of online CE-MS is not without challenges. Understanding of CE, the interface setup, ionization technique and mass detection system is important to tackle problems while coupling capillary electrophoresis to mass spectrometry. In this article, instrumentation details of CE-MS, the technical aspects of CE‐MS interface, applications and the advancements made in recent years are...
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