Posted by admin on Jan 31, 2020 in |
The purpose of this review article is to discuss in detail about technology transfer in the pharmaceutical industry. The article highlights the objective, reasons for undergoing technology transfer, factors which affect technology transfer, steps involved in technology transfer process. Clearly explains the technology transfer documentation part this is an attempt to understand the aspects related to technology transfer. The transfer may be said to be successful if the receiving unit and the transferee can effectively utilize the technology for business gain. The success of any particular technology transfer depends upon process understanding or the ability to predict accurately the future performance of a process. Three primary considerations to be addressed during an effective technology transfer are the plan, the persons involved and the process. The technology transfer does not mean one-time actions taken by the transferring party toward the transferred party but means continuous information exchange between both the parties to maintain the product...
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Posted by admin on Jan 31, 2020 in |
Now a day’s control delivery of the drug is easily achieved by Microsponge delivery system. These microsponges are very similar to polymeric porous microspheres. In general microsponges are 5-300 micron in diameter, spherical in shape, large porous surface, tiny in structures. Microsponges generally used in the topical drug delivery system but recently they are used for oral administration of drugs. Microsponges deliver its drug on regular time intervals and also respond to the other stimulations. A microsponge has advantages that they modify the release of the drug enhances the stability and effectively reduces the side effects of the drugs. The main aim of formulation is to achieve desired concentration of the drug in the blood. When these microsponges used topically they prevent the accumulation of the drug in both dermis and epidermis. Microsponges can easily entrap and formulated into pharmaceutical product such as gels, creams, powders, liquids, and suspensions. One of the best features of microsponges is it has self-sterilization property; numerous study has confirmed that microsponges are non-...
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Posted by admin on Jan 31, 2020 in |
Capparis moonii wight is a large woody climber or shrub (locally known as Rudanti) having Rasayana (rejuvenating) actions and it is being used in respiratory diseases like cough, bronchial asthma and pulmonary tuberculosis by ayurvedic physicians. It is one of the drugs which have references for its use from centuries but still not much explored in this contemporary era. The review aims to provide a critical and comprehensive evaluation, from the ancient times to our days, of the ethnological, botanical, chemical and pharmacological aspects of Capparis moonii, with a vision for promoting further pharmaceutical research to explore its complete potential as a therapeutic agent. This study was performed by reviewing in extensive details the studies on historical significance and ethnopharmacological applications of Capparis moonii by using classical ayurvedic texts, international scientific databases, books, etc. In addition, the plant taxonomy was validated using certified databases such as Medicinal Plant Names Services (MPNS) and the plant list. A detailed comparative analysis of the available sources for Capparis moonii wight confirmed that...
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Posted by admin on Dec 31, 2019 in |
The fungus candida with over 355 species is an anamorphic yeast. It consists of over 20 human pathogenic species which are the cause of candidiasis. Candidiasis encompasses infections that range from superficial, such as oral thrush and vaginitis, to systematic and potentially life-threatening diseases. Candida species are opportunistic human pathogens which despite treatment with antifungal drugs can cause fatal infections in immune-compromised and immune-deficient patients. C. albicans, C. glabrata, C. tropicalis and C. parapsilosis, together account for about 95% of identifiable Candida infections. C. albicans, considered to be the most serious cause of candidiasis, is a diploid, polymorphic yeast producing three morphologic forms: yeast cells, pseudohyphae, and true hyphae. This phenotypic switching plays a vital role in virulence. Since invasive yeast infections are associated with high levels of morbidity and mortality so rapid and accurate identification can contribute to successful therapy, earlier resolution of infections and subsequent reduction of moribund outcomes. CHROM agar candida, a type of chromogenic medium, based on species-specific enzyme activity, has been found to be...
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Posted by admin on Dec 31, 2019 in |
Phytase catalyzes the formation and release of inorganic phosphate from phytic acid. A few monogastric animals that lack phytase is incapable of digesting phytate obtained from plants and gets excreted, which results in the accumulation of phosphorus in the form of phytate in the environment which has a detrimental effect. In order to combat this problem, researchers have focused on production and purification of phytase from different microbial sources, which converts phytate to useful form of phosphorous that facilitates plant growth. This review paper summaries the various methods adopted for isolation, production, and purification of phytases from various...
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