Posted by admin on Mar 31, 2025 in |
Diabetes mellitus is a chronic metabolic disorder characterized by high levels of glucose in blood due to non-secretion of insulin or insulin insensitivity. Diabetes mellitus can cause many complications, acute complications include non ketotic hyperosmolar coma and diabetic ketoacidosis. Different types of diabetes mellitus are available – Type 1 diabetes mellitus (hormone dependent diabetes) and Type 2 diabetes mellitus (non-insulin dependent polygenic disorder mellitus) are now recognized as serious global health problem, growing rapidly worldwide and taking its place one of the main theats to human health in the 21st century. In diabetes history gestational diabetes is the major and big problem, approximately 5 to 10 percent all pregnant women in the India is diagnosed as having gestational diabetes. The main indication of diabetes mellitus is a hyperglycemia in blood which due to in appropriate pancreatic insulin secretion or low insulin directed fostering to glucose by target cells. It is silent and affects millions of people in the world. It is estimated that in 2010 there was globally 300...
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Posted by admin on Mar 31, 2025 in |
The respiratory drug delivery system (RDDS), which delivers drugs straight to the lungs for quicker effect and better bioavailability, is essential for treating respiratory disorders. It works particularly well for treating lung infections, COPD, and asthma. Metered-dose inhalers (MDIs), dry powder inhalers (DPIs), nebulizers, and sophisticated aerosol formulations are examples of technology that are part of RDDS and maximize medication delivery to the lungs. Particle size, the drug’s physicochemical characteristics, and patterns of deposition within the respiratory system are some of the variables that affect how effective RDDS is. For example, smaller particles enhance therapeutic benefits by reaching deeper parts of the lungs. To ensure effective medication deposition while reducing adverse effects, the delivery system’s composition and design are essential. New developments in formulation science, nanotechnology, and inhaler design have propelled recent advances in RDDS. By improving treatment’s portability, accuracy, and convenience, these advancements are increasing patient adherence. Modern inhalers, for instance, provide improved particle accuracy and dosage control, increasing the treatment’s total efficacy. With its potential to revolutionize...
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Posted by admin on Feb 28, 2025 in |
Schedule M is considered as an important part in the Drugs and Cosmetics Act 1940, Rules 1945. For making a product with proper quality and effective for the human beings it is necessary to maintain or follow the guidelines of schedule M. Schedule M is considered as the guidelines which talks mostly about Good Manufacturing Practices. Schedule M was first established in the year 2001 and it was divided into Part 1 and Part 2. Then in the year 2018 it was divided into 12 Parts more precisely than first one which was established in the year 2001. Then in the year of 2024 it became more precise, and it was divided into 13 Parts and including the changes introduced in, the revised Schedule M which include introduction of a Pharmaceutical Quality System (PQS), Quality Risk Management (QRM), Product Quality Review (PQR), Qualification and Validation of Equipment, and a Computerized Storage system for all drug products. These revised Schedule M will help in making the product proper and effective...
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Posted by admin on Feb 28, 2025 in |
Acne vulgaris is a common chronic inflammatory skin disease found predominantly in adolescents in both sexes. The best acne treatment inhibits bacterial growth, encourages the shedding to the skin cells to unclog pores. Treatment for acne includes topical agents and systemic agents. Its quality monitoring becomes essential for assuring quality products for human care. So, for that purpose a detailed study of review was done including reported and validated methods, official monograph methods for estimation of Nadifloxacin and Adapalene. It was found from a literature survey that among all reported evaluation methods the most widely and predominantly followed method is HPLC. Other methods reported were UV, HPTLC. A conclusion was made that there is lack of evaluation analytical methods for simultaneous estimation of Nadifloxacin and Adapalene in combined dosage...
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Posted by admin on Feb 28, 2025 in |
Anethum graveolens (Dill) leaves and seeds of the plant are mainly used for traditional health treatments like diuretics and stomach disorders. Various observations of Anethum graveolens plant oil and other extracts showed antidepressant, analgesic, antiproliferative, antimicrobial, anti-inflammatory, analgesic, antioxidant activity, effects on gastrointestinal system, hyperlipidaemic effects, contraindications and adverse effects, and effects on reproductive system. Further, it is also used to prevent food spoilage or contamination. In the food industry, it is also used for flavoring foods. The important isolated molecules reported are carvone, dihydrocarvone, limonene, cymen, carvacrol, phellandrene, coumarins, flavonoids, phenolic acids, steroids, etc. The various traditional uses of the plant parts are stomachic and diuretic in Ayurvedic...
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