Posted by admin on Apr 30, 2020 in |
Plants form the basis of human and animal life. Plants are better choice for medicinal applications when compared to synthetic chemicals and the nature has provided various types of medicinal plants. Jasminum grandiflorum Linn. (family Oleaceae) is a night bloomy flowering plant and is an important source of methyl jasmonates which find utility in plant defense, fruit ripening, plant growth senescence and other physical processes. The aroma plant Jasminum grandiflorum Linn. is native to tropical and warm temperate regions and the plant is observed to have favorable properties which can be used to treat numerous ailments. The leaves of the plant find clinical use in Ayurveda for wound management. The flowers of the plant are used to adorn the women coiffure. In this article, an attempt has been made to provide an updated review on this plant with focus on the isolation and quantification of chemical constituents, medicinal potential and patents on the medicinal and cosmetic formulations comprising Jasminum grandiflorum...
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Posted by admin on Apr 30, 2020 in |
COVID-19 is a disease caused by the novel coronavirus, which was initially called 2019-nCoV, consequently termed as SARS-CoV-2 by the experts of the International Committee on Taxonomy of Viruses (ICTV) as it is exceptionally alike to the virus that caused the SARS outbreak in 2002 to 2003. World Health Organization already had declared COVID-19 as an international emergency as the disease is spreading at alarming levels. COVID-19 has affected more than 1,016,372 people around the world and killed more than 53,238 people. And even where the virus hasn’t yet spread, hospitals and clinics around the world have been preparing for a rush forward of coronavirus patients as a priority over everyday illnesses they treat. The label ‘international emergency’ has triggered governments of various countries to activate vigilance plans and probably take emergency measures to protect the public, such as more strong travel and trade restrictions. It is being observed that this is the first time this kind of virus, a coronavirus, has been labeled a pandemic, “but at the...
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Posted by admin on Apr 30, 2020 in |
The mammalian central nervous system is composed of the brain and spinal cord. The brain is protected by the blood-brain barrier (BBB) that allows selective traffic of substances into the brain. Fluoride is a highly toxic and reactive element. We get exposed to fluoride due to its common use in toothpaste, dental gels, non-stick pans, razor blades, etc. Fluoride also enters our food chain through fishes that are cultivated in water bodies, which get contaminated with fluoride from running water from farms around it. Fluoride can accumulate on our body and cause toxic effects. In the context of fluoride, it is reported that fluoride exposure causes various toxic effects in our body, including the central nervous system as well. Fluoride is known to cross the blood-brain barrier and enter our brain tissue. It interferes with the normal metabolic process of the brain, generates free radicals and causes various toxic effects therein. Fluoride has been found to be linked to various pathogenic conditions of the brain as well. In this...
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Posted by admin on Mar 31, 2020 in |
In targeted drug delivery systems, there is one of the most important drug delivery systems is colon targeting drug delivery system. This system is mainly used in the treatment of diseases like colonic cancer, ulcerative colitis, Crohn’s disease. For local treatment of various bowel diseases colon is highly desirable. For the systemic action of nonpeptide drugs i.e., cardiovascular and antiasthmatic agents and protein-peptide drugs such as insulin, calcitonin, colon targeting is apparently useful. There are various approaches that have been proposed for targeted colon delivery; they include the pH, pressure controlled, time-controlled, microflora, osmotic controlled, and multi-particulates and novel techniques. The carriers used in this system are microsphere, synthetic polymers, liposomes and nanoparticles, matrix tablets and compression coated tablets...
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Posted by admin on Mar 31, 2020 in |
Remarkable pharmacological effects exhibited by Guggulsterone (GS) establish its potential as an effective anticancer agent. GS is widely known for its anti-inflammatory and hypolipidemic activities. At the molecular level, GS is known to modulate the activity of various nuclear receptors, growth factors and transcription factors. However, the complete sequence of the underlying anticancer mechanism of GS is not completely understood. Prostate cancer (PCa) initiation is marked with inflammatory events and disease advances towards castration-resistant prostate cancer (CRPCa) through constitutively activated androgen receptor and hyperactivated survival signaling such as NF-kB; therefore PCa cell lines offer a good model system to study the anticancer activities of GS. Considering the fact that GS is both anti-inflammatory and androgen receptor (AR) antagonist, it can be widely employed to achieve two objectives simultaneously – chemoprevention as well as an anti-cancer agent. Evidence from preclinical trials and prescribed usage in Ayurvedic medicine has promoted the use of guggul as a health supplement. However, the use of GS is not completely free of side effects and...
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