Posted by admin on Jul 31, 2019 in |
Diabetes is a metabolic disorder, which is characterized by insulin deficiency, insulin resistance, and aberrant metabolism in glucose, protein, and lipid. The primary causes of diabetes are Genetic and environmental factors. Diabetes is a chronic progressive disease that leads to both microvascular and macrovascular complications. This disease affects around 5% of the world population now. But, recently available oral antidiabetic agents used in orthodox medicine have unmet efficacy and undesirable side effects in patients. Therefore, Research is a significant deal requirement for the development of new remedies for diabetes are in high demand. Surveys expect that complementary and alternative medicine (CAM) is used by 80% of the world population for their primary health care. Therefore, CAM represents one of the most important options for therapy for diabetes. The objective of this work is to provide a starting point for programs leading to the development of indigenous flavonoids botanical resources as inexpensive sources for standardized crude antidiabetic drugs, and the development of lead compounds for new hypoglycemic drug...
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Posted by admin on Jun 30, 2019 in |
Acne is a common inflammatory disorder which is common among the adolescent age groups. Even though it is not a life-threatening disease but it affects the patient’s self-esteem. Additionally, they have also gone into depression and suicidal ideation. Based on the severity it can be classified into several types. Various factors are responsible for the occurrence of acne. The main factors are discussed in this article. According to the Global Burden of Disease study about 85% of the populations are being affected when we consider the epidemiology. Among this, the Americans are most prone to it. A variety of medications are available in the market for the treatment of acne like retinoid derivatives, benzoyl peroxide, and antibiotics etc. Among which the topical treatment is most preferred. Other treatments are carried out only if the existing treatment doesn’t give the desired results. Nanotechnology has also been incorporated for the existing drug in order to target the disease. Acne can be induced in the animal. Existing works of literature gives information...
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Posted by admin on Jun 30, 2019 in |
Costus pictus is rhizomatous medicinal herb, commonly known as “Insulin plant,” well known for its therapeutic properties. Many important and beneficial aspects of C. pictus are reported, which includes anti-diabetic, anti-microbial, anti-cancer, anti-oxidant, anti-fertility, anti-helminthic, diuretic, anti-inflammatory properties. The present review focus on the literature survey based on their occurrence, nature of plant, distribution, pharmacologically important bio-active compounds, utilized in the treatment of diabetes and related disorders. Along with micropropagation of Costus pictus under the aspectic condition and molecular approaches towards the treatment of disorders and different pathways involved. This summarized review focus on the future scope of research and development for synthesis of much effective dose and dosage period to formulate the therapeutic potential of Costus pictus and their...
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Posted by admin on Jun 30, 2019 in |
Polycystic ovarian syndrome (PCOS) is a reproductive metabolic disorder affecting nearly 20% females, globally. Though Rotterdam consensus is widely used for assessment, it lacks definite diagnostic guidelines. Absence of PCOS guidelines for adolescent and post-menopausal women might be influencing the prevalence data. The prevalence varied with ethnicities and found high in urban than rural. Among women in reproductive age, the obese rural population also found vulnerable to PCOS, indicates the role of lifestyle factors in this syndrome. Erratic lifestyle predisposes to insulin resistance, or obesity leads to subsequent hyperinsulinemia and hyperandrogenemia. Also, genetic predisposition to hypothalamic pituitary gonadal (HPG) axis dysfunction and impaired ovarian steroidogenesis further influence the disorder. It dysregulates the oocyte maturation leading to polycystic ovaries, thereby, affects the normal ovarian functions. The environmental toxins which are endocrine disruptors further worsens the consequence of the disorder. Multiple factors make it difficult to decipher the independent pathway of pathogenesis. Apart from ovulatory and reproductive dysfunctions, PCOS have chronic metabolic consequences: cardiovascular disease (CVD), obesity, dyslipidemia, obstructive sleep apnoea,...
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Posted by admin on Jun 30, 2019 in |
Tuberculosis is a bacterial infection which is caused by the bacteria Mycobacterium tuberculosis. It is next to AIDS and causes morbidity and mortality. These bacteria can stay in the host’s body for decades. In this article we have mentioned about the pathogenesis of pulmonary tuberculosis followed by the pathogenesis of tuberculous meningitis wherein the bacteria first enter to the lungs which then form into macrophages, these macrophages form into granulomas which get ruptured and enter the brain and then enter the subarachnoid space causing tuberculous meningitis. The current treatment methods available, their dosage forms and penetrance into the CSF is also mentioned. Usually, the first line drugs are used in combination to treat the disease but in the case of resistance second-line drugs are used. The duration of the treatment depends on the severity of the disease. Even though, there are many drugs available to treat the disease the amount of drug entering the brain is minimal due to the presence of the blood-brain barrier (BBB). So, due to...
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