Posted by admin on May 31, 2019 in |
Dapagliflozin (DAPA) is a drug of gliflozin class. It is a white crystalline solid. Dapagliflozin is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity. Dapagliflozin blocks glucose reabsorption into the kidney, resulting in the elimination of blood glucose through the urine. DAPA is not official in any pharmacopeia. It comes under EU Pharmaceutical Product Classes, as per literature survey. Till date officially no analytical method has been developed or reported for this drug. This review focuses on collective literature on the analytical methods developed for...
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Posted by admin on May 31, 2019 in |
The fruit of Terminalia chebula is an essential drug used in single and in many compound formulations of Indian traditional systems like Ayurveda & Siddha and Unani systems of medicine. This herbal drug is referred to as ‘The king of medicines’ which denote it’s efficacy and potency in treating diseases. The TCF is the richest source of phenols among other plants and is cherished with lead active ingredients with high scope for drug discovery for a spectrum of diseases because of the five tastes except for the salty taste in it. As global acceptance of traditional drugs increase in the past decades, compliance with the quality in terms of standard parameters and regulatory laws on the drugs also are sharpened. Drugs of poor quality degrade the clinical efficacy and also create a query on safety concerns. Authentication of a drug to be a genuine variety is of prime importance in standardization. Terminalia sps. are numerous. Seven types of medicinally useful TCFs are mentioned by the Siddhar (sage) Agathiyar based...
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Posted by admin on May 31, 2019 in |
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders in the population above 60 years of age. The movement abnormalities in PD are credited due to an imbalance between the acetylcholine and dopamine which results in uncontrolled movements. It is characterized using resting tremor, postural impairment, bradykinesia, and rigidity. The degeneration of midbrain dopaminergic neurons and accumulation of inclusions containing α-synuclein (termed “Lewy bodies”) throughout the nervous system are few of the most prominent features of PD. Still, there is no cure; we have several management options for the early treatment of PD. Several objective methods have been proposed for improving the diagnostic accuracy of PD, for enabling earlier diagnosis, to quantify the severity of disease and progress of treatment given. These methods include motor performance tests, olfaction tests, imaging techniques, and biochemical tests of blood and cerebrospinal fluid. None of the proposed methods is widely available or clinically used for PD. The validation of the objective methods takes time, and a large number of regulatory requirements...
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Posted by admin on May 31, 2019 in |
Alpinia is the largest and most taxonomically complex genus in the Zingiberaceae family. This includes about 230 species and widely spread throughout forests in tropical and subtropical Asia. Many of species are herbs and rich sources of bioactive compounds that extensively used in various purposes ranging from its use in culinary, prevention of diseases and ornamental purposes. There is no reported systematic method to differentiate many of the species within the genus particularly species used in medicinal preparations except heavily used ones. Many species in this genus could have the potentials to be utilized commercially due to valuable phytochemicals but never subjected to any kind of systematic study. Therefore, a proper morphological and physicochemical identification is a must to maintain sustainable exploration of many species of the genera. This review focuses on gathering information regarding genus Alpinia including morphological characteristics, phytochemicals, and their biological activities which provide information for further advance research...
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Posted by admin on Apr 30, 2019 in |
Aging is a natural phenomenon; it is a well-known fact that everyone is aging as time passes. A major contributor to this process is cell senescence. Cell senescence can be a result of the exposure to stress such as oxidative stress, epigenomic damage or DNA damage, or it can be due to telomere shortening is also known as end replication problem. It was first observed by Hayflick. Senescent cells show a distinctive feature called Senescent associated secretory phenotypes (SASP) which includes increased expression of p16 and Beta-galactosidase can be used as a marker for senescent cells. Senescent cells are involved in exacerbating various kinds of age-related disorders such as diabetes, obesity, cardiovascular diseases, neurodegenerative diseases, etc. This review is focused on the major factors responsible for cell senescence, its related pathways, and the role of cell senescence in neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. The paper also throws light on how cell senescence can be used to treat cancer known as therapy-induced senescence and various strategies to...
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