Posted by admin on Jun 30, 2025 in |
Hypertension is a ubiquitous and serious worldwide health concern, having a dramatic influence on individual health outcomes. In light of this rising worry, Azelnidipine, a third generation long-acting dihydropyridine calcium channel blocker, has emerged as a prospective therapeutic treatment. A vast body of research has indicated that Azelnidipine produces a strong antihypertensive impact, especially in individuals diagnosed with essential hypertension, thus validating its therapeutic usefulness in controlling this prevalent illness. This thorough study strives to give an in-depth overview of the numerous analytical techniques applied for the measurement of Azelnidipine. It covers a variety of techniques, including spectroscopic UV analysis, as well as chromatographic methods such as reversed-phase high-performance liquid chromatography (RP-HPLC), high-performance thin-layer chromatography (HPTLC), and ultra-performance liquid chromatography (UPLC), either alone or in combination with other drugs. These methodologies together give useful insights into the reliable measurement of Azelnidipine in pharmaceutical formulations. These techniques are tested for accuracy, precision, and resilience according to ICH criteria. They are excellent for both bulk medication and tablet dose forms because...
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Posted by admin on Jun 30, 2025 in |
A new method in this field called film-forming gels may offer an alternative to the common skin dosage forms such ointments, creams, gels, or patches. When applied as a liquid, the polymeric solution evaporates to create a nearly undetectable layer on the skin. Dermal medication delivery and transdermal drug delivery systems compared to traditional pharmaceutical dosage formulations, the approach can offer certain desirable performance, for eliminating first-pass metabolism in the stomach and liver, increasing medication bioavailability, lowering dosage frequency, and stabilizing drug delivery overview. The purpose of this review was to find alternatives to traditional forms that would decrease skin irritation, boost patient acceptability from a cosmetic standpoint, improve skin adhesion qualities, and enhance drug release. The unique rheological nature of polymeric gels makes them advantageous in terms of preparation simplicity. Application simplicity, adherence to the application surface, and broad drug delivery...
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Posted by admin on Jun 30, 2025 in |
Post-traumatic stress disorder (PTSD) affects a significant portion of the global population and can lead to chronic psychiatric complications and other secondary health issues. Among these, cardiovascular disease (CVD) stands out prominently. The relationship between PTSD and CVD is complex and bidirectional, with PTSD increasing the risk of developing CVD and worsening its prognosis. This review explores the physiological, psychological, and behavioral pathways through which PTSD influences cardiovascular health, including dysregulation of the autonomic nervous system, chronic inflammation, and endothelial dysfunction. These mechanisms highlight the profound impact of PTSD on cardiovascular risk factors such as hypertension, dyslipidemia, and metabolic syndrome. Effective management strategies necessitate integrated approaches that address both PTSD symptoms and cardiovascular risk factors, emphasizing early intervention, lifestyle modifications, and psychological therapies. Understanding and managing the PTSD-CVD link is crucial for optimizing care and improving outcomes in affected...
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Posted by admin on Jun 30, 2025 in |
Background: Pharmacogenomics, a cornerstone of precision medicine, studies genetic variations that influence individual drug responses. By leveraging genomic technologies, it enables personalized medicine, optimizing drug efficacy and reducing adverse effects. Objective: This review provides a comprehensive overview of pharmacogenomics, examining its scientific principles, technological advancements, clinical applications, and associated challenges, alongside emerging trends like AI and big data. Methods: A systematic literature review of recent peer-reviewed studies, clinical research, and regulatory reports was conducted using databases such as PubMed, ScienceDirect, and Google Scholar. Key Findings: Pharmacogenomics focuses on genetic variability in drug metabolism (e.g., CYP450 enzymes), driving personalized therapies. Clinical successes in oncology, cardiology, psychiatry, and infectious diseases underscore its benefits. Advances in next-generation sequencing, GWAS, and bioinformatics tools like PharmGKB have propelled research and clinical integration. However, challenges include rare gene-drug interactions, high costs, healthcare disparities, and ethical concerns related to genetic data. Future directions emphasize gene-editing technologies, diverse population studies, and AI-driven discoveries. Conclusion: Pharmacogenomics offers transformative potential for healthcare through individualized therapies. However, its widespread clinical...
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Posted by admin on Jun 30, 2025 in |
This article explores the transformation of pharmaceutical research and development by the combination of digital twins and generative artificial intelligence (AI), especially in drug discovery. It highlights various cases that illustrate the increasing use of digital twins of biological systems alongside generative AI algorithms to speed up the identification of new drugs. This approach involves simulating vast chemical landscapes and predicting molecular properties, which facilitates the discovery of novel compounds that may have previously been overlooked. By leveraging computational models and machine learning, researchers can design targeted compounds, refine potential therapy candidates, and simulate their interactions within complex biological environments. This method accelerates the identification of promising drug candidates while predicting their efficacy and safety more efficiently, without extensive in-vivo testing. Furthermore, digital twins allow for a more personalized approach to drug development, enhancing the chances of success for specific patient groups. This cutting-edge methodology presents significant opportunities to streamline drug development processes, lower costs, and ultimately improve patient outcomes by delivering more effective treatments. However, the integration of...
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