Posted by admin on Feb 28, 2025 in |
Recent years have witnessed remarkable advancements in biomedical sciences, particularly in the realm of mRNA (messenger ribonucleic acid) technology. This manuscript offers a detailed overview of the burgeoning field of mRNA and its profound implications in science and medicine. Beginning with an introduction that elucidates the fundamental concepts and historical evolution of mRNA technology, the discussion progresses to an in-depth exploration of its structure, function, and pivotal role in modern medicine. The differences between mRNA and DNA are clarified to underscore the unique attributes of mRNA. A significant focus is given to mRNA vaccines, hailed as breakthroughs in preventive medicine. The exploration extends to mRNA therapeutics, highlighting their potential in targeted drug delivery and their ability to overcome traditional pharmaceutical challenges. Issues surrounding the efficacy and safety of mRNA applications are addressed, emphasizing importance of safety and ethical considerations. Present difficulties and potential paths in mRNA technology are discussed, underscoring ongoing research and innovative prospects. This review elucidates the transformative potential of mRNA technology, offering insights into its current...
Read More
Posted by admin on Feb 28, 2025 in |
The phenomenon known as mucoadhesion is characterized by interfacial molecular attractive forces between a natural or synthetic polymer and the surface of a biological membrane. This allows the polymer to stick to the membrane’s surface for a prolonged period of time. The idea of mucoadhesion has garnered significant attention in many pharmaceutics sectors during the past forty years. The mucoadhesive buccal drug delivery system has numerous benefits that make it a unique drug delivery method for both local and systemic administration of different medications. The primary benefit of using this route for medication administration is that it avoids the initial metabolic stage of many methods circumvents the first pass metabolism of a number of medications that are susceptible to their first pass metabolism in the liver. Mucoadhesive drug delivery system contacts with mucus layer and generally increases the retention time of the dosage form at the specific site of absorption. The structural characteristics of the mucosa, the mechanism of mucoadhesion, various theories of mucoadhesion, are briefly discussed in this...
Read More
Posted by admin on Feb 28, 2025 in |
Malnutrition continues to be a significant public health concern, affecting the survival, growth, and well-being of both current and future generations, especially in developing nations such as India. This study examines the intricate characteristics of malnutrition, including insufficient and excessive nutrition, with a major emphasis on protein-energy malnutrition (PEM) in children, the high occurrence of stunting, wasting, and underweight conditions in children, based on data from the National Family Health Survey (NFHS-5) and multiple studies conducted in Jaipur. It emphasizes the notable gender discrepancies and socio-economic factors contributing to these conditions. Ayurveda emphasizes the significance of maintaining a well-balanced diet (Aahara) and recognizes the influence of Vata dosha in disturbing the process of digestion and absorption of nutrients, resulting in ailments like Karshya, Balashosha, and associated disorders. Ayurvedic therapies prioritize dietary alterations, herbal supplementation, and lifestyle adjustments to restore physiological equilibrium and enhance overall well-being. This article suggests incorporating Ayurvedic concepts into current government nutrition initiatives, such as POSHAN Abhiyaan and Pradhan Mantri Matru Vandana Yojana (PMMVY). Concrete suggestions encompass...
Read More
Posted by admin on Jan 31, 2025 in |
The Expanded Programme on Immunization (EPI), launched in 1974, is the world’s major vaccination program against vaccine preventable diseases. Despite progress, the program’s success, measured through coverage rates, has recently stalled, especially in low-income countries where access to vaccines remains challenging. EPI’s effectiveness relies heavily on the Immunization Supply Chain, but technological changes and new vaccine introductions have strained these systems, leading to stock-outs and risks due to outdated cold chain equipment. These challenges cause health disparities and undermine immunization coverage, particularly in contexts constrained by resource scarcity. Launched in 2010, Effective Vaccine Management (EVM) initiative addresses some of these concerns by improving and evaluating vaccine supply chain systems at large scale globally. This study, utilizing the EVM 2.0 to analyse data from 57 nations that are in the public domain between 2019 and 2023 using the EVM 2.0 assessment tool, offers an analysis of Immunization Supply Chain. The review shows the composite score of 73 which depicts an average performance overall with strengths in financial, human and managerial...
Read More
Posted by admin on Jan 31, 2025 in |
The majority of novel chemical entities getting discovered are having low water solubility and it must be addressed to distribute the drug more effectively. SMEDDS, a lipid-based drug delivery approach, is thought to boost oral absorption of less hydrophilic drugs. Surfactants are the major excipients used in SMEDDS as they are responsible for the emulsification process. The two main criteria while choosing a surfactant should be HLB and safety. A high emulsifying property is what the emulsifier employed in SMEDDS formulation is ought to have. The high hydrophilicity and HLB value of a surfactant guarantees instant oil-in-water droplet production and fast dispersion of formulation in aqueous fluids. The most frequently advised and preferred surfactant type used in SMEDDS are non-ionic surfactants with a rather high HLB value. A high concentration of surfactant is required for a stable self – micro-emulsifying drug delivery systems and they usually contain surfactant concentrations in the range of 30% to 60% w/w. Surfactants that are suitable for use in pharmaceuticals include kolliphor RH40, Cremophor® RH40,...
Read More
