Posted by admin on Apr 30, 2019 in |
Present study explains the cancer nano-therapeutics which is rapidly progressing and are being implemented to solve several limitations of conventional drug delivery systems such as nonspecific biodistribution and targeting, lack of water solubility, poor oral bioavailability. To improve the bio-distribution of cancer drugs, nanoparticles have been designed with optimal size and surface characteristics to increase their circulation time in the bloodstream. They are also able to carry their loaded active drugs to cancer cells by selectively using the unique pathophysiology of tumors, such as their enhanced permeability and retention effect and the tumor microenvironment. In this review, we will address, first, the types and characteristics of nanoparticles; second, how nanoparticles are being used as drug delivery systems to kill cancer cells more effectively and also to reduce or overcome drug resistance; and third, how nanoparticles had been formulated and evaluated to improve their therapeutic action, efficacy, and functionality in future cancer treatments. Finally, nanoparticles have greater therapeutic action towards cancer...
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Posted by admin on Apr 30, 2019 in |
Rheumatoid arthritis is a very common auto-immune inflammatory disorder, causing disability in developed and developing countries. Conventional drugs are not only costly but are also associated with very serious adverse effects. Several Indian medicinal plants have been traditionally used for their anti-arthritic effect since time immemorial. Present review focused on the immunomodulatory potentials and anti-inflammatory action of some selected medicinal plants in order to generate the experimental evidence of their therapeutic efficacy in this disease and thereby putting the base for the designing of advanced and safer drugs for this condition, thereby leading to the finding of alternative therapeutic process that can offer enhanced management of the disease. Further, these plants extent studies can result in an eco-friendly cost effective anti-arthritic herbal drug with anti-inflammatory properties contributing to the better maintenance of human society. This review summarizes the different studies performed using these medicinal plants screened for rheumatoid arthritis concerning the chemical constituents, screening methods and therapeutic moieties which will be a remarkable tool for the researcher who involves...
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Posted by admin on Apr 30, 2019 in |
Indole and coumarin are the most versatile and cogent heterocyclic scaffolds which are not only decisively used in the synthesis of various organic compounds but also play a consequence role in natural product synthesis, modulation of biofilm formation, virulence and stress responses. In last few decades, an individual has witnessed considerable activity towards the synthesis of indole derivatives due to the possibilities for the design of polycyclic structures by the incorporation of multiple fused heterocyclic scaffolds in an attempt to achieve promising new heterocycles with chemical and biomedical relevance. Whereas, coumarin is a 2-oxo-2H-1-benzopyran and, also, have a wide range of application in the pharmaceutical field. In this review, we provide an overview of the synthesis of coumarin and indoles and their pharmacological evolution. The coumarin was synthesized using phenols, salicylaldehyde, benzaldehyde, phenylacetate, styrenes, and cinnamic acid with different catalyst and photocatalyst to give the best yield. Similarly, Indoles were synthesized iodobenzoic acid, alkynes, amines, alcohols, Nitrobenzaldehyde with the different catalyst under conventional and irradiation method. The effect of...
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Posted by admin on Apr 30, 2019 in |
Transdermal drug delivery system (TDDS) provides a leading edge over injectables and oral routes by increasing patient compliance and avoiding the first-pass metabolism respectively. Transdermal delivery not only provides controlled, constant administration of the drug, but also allows continuous input of drugs with short biological half-lives and eliminates pulsed entry into the systemic circulation, which often causes undesirable side effects. The oral route of transdermal drug delivery enables avoidance in gastrointestinal absorption. One of the greatest innovations of novel drug delivery in transdermal patch skin adhesion is the most important functional properties for a TDDS. Poor adhesion results in improper dosing of patients and potential accidental dosing of patients, who may pick up fallen patches. The adhesive of the TDDS is critical to the safety, efficacy, and quality of the product. Drug therapy may be terminated rapidly by the removal of the application from the surface of the skin. This article provides a framework for scientific work to improve transdermal adhesive performance and provides an overview of types of...
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Posted by admin on Apr 30, 2019 in |
Mushroom extracts such as proteins, amino acids, polysaccharides and vitamins implicated as the reducing, stabilizing and capping agents in synthesis of myconanoparticles. Therefore, it is just a little attempt to study the journalism of this important of myconanoparticle. For this literature survey, basically library data was collected and digital resources were also included. From these sources we obtained reliable information about diverse nanoparticle synthesis from different mushroom species. Myconanotechnology is used in numerous medical applications like diagnosis of various diseases, therapeutic field and other applications like catalysis of bio molecules, microelectronics, biosensing devices, air and water purifiers and paints. Studies by different researchers specify that myconanoparticles possesses various pharma-cological activities such as antimicrobial activity, anticancer activity, anti-proliferative activity, and various other effects like antioxidant activity, cellular uptake, catalytic activity etc. There are many literatures demonstrating the various global uses of myconanoparticles. Till date very inadequate information is available from different sources so, we try to assemble this information in one review article. This review article gives an account of...
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