Posted by admin on Feb 28, 2019 in |
Inflammatory bowel disease (IBD) refers to the inflammation of the colon and small intestine of the body, in which Crohn’s disease and ulcerative colitis are the principal types of IBD. This article covers most of the information related to a drug delivery system for treatment regarding intestinal diseases more emphasized to inflammatory bowel diseases. Currently, using delivery systems for targeting drugs to colon are osmotic drug delivery system, chronotropic system, pulsinicap system, multiparticulate system, port system, COLAL-Pred system, gas empowered drug delivery system have included in this article. An approach for targeting drugs to the colon is a probiotic approach has also included in this article. These delivery systems are being used to improve the bioavailability of the poorly absorbed drug. The purpose of this review article is to study about techniques employed in colon targeting for the prevention and treatment of...
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Posted by admin on Feb 28, 2019 in |
Alzheimer disease (AD) is the most common cause of dementia which affects more than 44 million individuals worldwide. It has been noticed that there is only symptomatic treatments are available to treat AD, but no cure exists. It is a neurodegenerative disease characterized by Alois Alzheimer’s in 1906, and neuro-degenerative diseases are one of the major concerns facing by the modern health care system. It is a multifarious complex disease which pathology not clearly understood but it is generally characterized by neuronal damage, memory dysfunction, etc. main pathological hallmark factor for Alzheimer disease is deposition of amyloid-β (Aβ) plaques around the neurons, neurofibrillary tangles, and a decrease in acetylcholine concentration and some other neurotransmitter dysregulation. Different types of risk factors like oxidative stress, obesity, diabetes, hypertension, air pollution, smoking, hyper cholesterolemia etc. have a very significant role in the development of AD and in the development of its preventive measures. Physical exercise and nutritional factors have been shown as protective measures for it and help in its prevention. For...
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Posted by admin on Feb 28, 2019 in |
Drug discovery and development plays a major role in the world and serves mankind. The major criteria to be considered and given importance in drug development is the solubility of a drug. Among all newly discovered chemical entities, about 40% of drugs fail to reach the market due to their poor aqueous solubility or lipophilicity. Poor solubility is not only a problem for formulation development and clinical testing but also an obstacle at the very beginning while screening new compounds for pharmacological activity. Nowadays oral route is considered as the preferred route of drug administration than other routes due to its convenience in terms of ease of administration and economy. The first requirement of drug which is supposed to be given by oral route is good aqueous solubility, as the poor solubility leads to low absorption, inadequate and variable bioavailability and also gastrointestinal mucosal toxicity. To prevent these crisis, several solubility enhancement techniques have been employed to enhance the solubility of poorly soluble drugs and hydrotropic solubilization is one...
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Posted by admin on Feb 28, 2019 in |
From the beginning of civilization, humans depend on the natural products for their food and as medical treatment. Diversity in various bioactive compounds from marine organisms has been tested for the multiple pharmacological effects. Marine algae are surviving in a competitive environment with developed defense strategies and significant levels of chemical structural diversity with a wide variety of bioactive secondary metabolites. Therefore, algae are a promising source of novel active biochemical compounds with different pharmacological properties for the prospective development of novel drugs by the pharmaceutical industries. Microalgae (blue-green, dinoflagellates, bacillariophyte, etc.) and Macroalgae (green, brown and red algae) are the two groups of algae. Caulerpa is the genera of green macroalgae, represent the numerous bioactive compounds like tannin, steroids, flavonoids, terpenoids, sulphated polysaccharides (SP), glycosides, phenolic compounds, and saponins, etc., for significant pharmacological effects in the current medicine. Exploration of these compounds for the pharmaceutical and medical purpose, the present review focused on morphological behavior and pharmacological activities of some Caulerpa species in current drug...
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Posted by admin on Feb 28, 2019 in |
Polycystic ovarian syndrome (PCOS) is one of the most prevalent endocrine disorders in females of reproductive age. Globally, it has been found that PCOS affects 10% of reproductive-age women when using the NIH criteria for diagnosis, and up to 18% of reproductive-age women are diagnosed with PCOS as per the Rotterdam criteria. Mostly symptoms of PCOS include irregular menstrual cycles, signs of hyperandrogenism and insulin resistance. Women with PCOS are at increased risk for developing reproductive, metabolic and cardiovascular disorders. The measures for management of PCOS targets the symptoms which are present in a patient such as lowering body weight and insulin levels, restoring fertility, treating hirsutism or acne, restoring regular menstruation and preventing complications. Early detection of long-term morbidities through appropriate screening tests constitutes an essential part of the management of this condition. Future research has to focus on the missing blocks in our growing knowledge about this condition, following that physicians will be able to provide the finest care for...
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