Posted by admin on Jun 30, 2018 in |
Science and technology have greatly contributed to man’s never-ending quest for quality improvement in different domains of life. But in the process of development, the usage of radiation-based technologies has considerably increased in the fields of medicine, agriculture, aviation, space, warfare, food processing, electronic and communication systems, nuclear-power generation and other industrial activities. These anthropogenic activities, in addition to natural processes, have more and more exposed humans knowingly or unknowingly to different kinds of radiations resulting in morbidity or mortality. In view of the high costs and side effects of the currently available radioprotective drugs, research continues to explore safe and effective radioprotectants preferably natural product-based ones. In the Traditional Indian and Chinese systems of medicine, several plant species have been reported to possess great medicinal values to treat various ailments. This article reviews and updates the promising plants and herbs, their extracts / bioactive principles and their mode of action as radio-protectants. Systematic and scientific studies pave the way to develop efficient drugs/formulations to protect or prevent from...
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Posted by admin on Jun 30, 2018 in |
Diabetes is one of the deadliest and non-contagious diseases that can adversely affect several parts of human body. Early prognosis of diabetes can inkling the grievous complications and help to save human life. Several researchers have used different data mining (Iterative Dichotomiser 3, Random Forest, Support Vector Machine, k-Nearest Neighbour, C4.5) and soft computing (Genetic Algorithm, Ant Colony Optimization, Particle Swarm optimization, Artificial Bee Colony) techniques to prospect diabetes in human beings. In last 10 years, C4.5 was the most preferred choice for mining diabetic patients. Likewise, in soft computing, maximum number of researchers have used genetic algorithm. Furthermore, the usage of pre-processing techniques is significantly increasing in diabetes diagnosis. It is also observed that rate of accuracy achieved in diagnosing diabetes using traditional data mining lies in 68.5% – 95.3%. Likewise, the range for soft computing and their hybridized use lies in 74% – 100%. In addition, rate of accuracy achieved using GA based hybridized approach is better than the accuracy obtained using PSO as well as ABC....
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Posted by admin on Jun 30, 2018 in |
Neurodegenerative disorders particularly Parkinson’s disease are serious threat for heath society. In addition, treatment, control and managing of Parkinson’s disease burden high cost to these patients. Therefore, an efficacy and available treatment strategy is required so that herbs and their bioactive compounds could be good candidates. It has well been demonstrated the herbs are a potential source of antioxidant and have anti-inflammatory property. Interestingly, oxidative stress and inflammation are main reasons neurodegeneration in substantia nigra pars compacta. Here, we review the studies conducted on effects of extracts and compounds obtained from herbs in treatment of Parkinson’s disease until 2000 to now by to focus on their effects on different animal model of Parkinson’s...
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Posted by admin on Jun 30, 2018 in |
The first case of middle east respiratory syndrome (MERS) was identified in a mid-aged Saudi Arabian resident in 2012. The syndrome is analogous to severe acute respiratory syndrome (SARS) in its clinical course, with a male predominance in incidence. MERS virus is disseminated as a result of close proximity of people to camels, person to person transmission being uncommon and confined to hospital settings. The incubation period usually lasts for 2 – 14 days. MERS-CoV appears to be an enzootic virus, tracing its origin to bats, whereas camels may act as intermediate hosts. Typical flu-like symptoms are observed, which include pyrexia, myalgia, apnoea and cough. Symptoms advance over time leading to multiple organ failure, septic shock and eventually death. Diagnosis can be done with the aid of recombinant IgA and IgG ELISAs, and other specific assays such as upE and real-time Reverse Transcription (rt-RT) PCR assay. Currently, neither an authorized vaccine nor a definitive treatment is available for human use. However, adenosine deaminase, mycophenolic acid (MPA), cyclosporine A, nelfinavir,...
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Posted by admin on May 31, 2018 in |
Vesicular systems have gained immense importance in the last few years as a means for sustained and efficient drug delivery. This article was designed to review all aspects of a novel class of vesicles, transfersomes. Tranfersomes and the fundamental concept of transfersomes were launched by Gregor Cevc in the year 1991. It exists as an ultra-deformable complex having a hydrated core surrounded by a complex layer of lipid. The carrier aggregate is composed of at least one amphipathic molecule (like phospholipids) which when added to aqueous systems self-assemble into a bilayer of lipid which eventually closes into a lipid vesicle and one bilayer softening agent which is generally a surfactant which is responsible for the flexibility of the vesicle. Transfersomes provide the primary advantage of higher entrapment efficiency along with a depot formation which releases the contents slowly. The characterisation of transfersomes is similar to that of other vesicles like liposomes, niosomes and micelles. Transfersomes can be used for delivery of insulin, corticosteroids, proteins and peptides, interferons, anti-cancer drugs,...
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