Posted by admin on Mar 31, 2018 in |
Molecular Dynamics (MD) Simulation provides the details explanation of the atomic and molecular interactions that directed by macroscopic and microscopic behaviors of the various systems. This review provides a brief do-how about the theory, procedure, algorithm, and uses of molecular dynamic simulations in different bimolecular systems. An in-depth analysis of different prospects of MD simulation viz. procedure of MD simulation, force fields, energy minimization and integration algorithms, concept of ensembles and thermostats with a list of associated software briefly explained. At last discussion of various applications of MD simulation using some recent works, indicates the potential contribution of MD in biological...
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Posted by admin on Mar 31, 2018 in |
Genus Urtica belongs to family Urticaceae and commonly known by name of nettles. The plant Urtica has been used as a folk medicine and as a food source from a long time. It has been used frequently for its medicinal properties since the Bronze age (3000 – 2000 B.C.) as a traditional herbal remedy in treatment of variety of diseases as rheumatism gouts, nephritis, haematuria, jaundice, menorrhagia, anemia, eczema, arthritis. It has been used for a long time as first-aid remedy in treatment of infirmities in case of bites and stings, burns, hives and breast feeding problems. Phytochemicals evaluation of the plant revealed presence of various chemical compounds like phytosterols, saponins, flavonoids, phenolic acids, tannins, proteins and amino-acids that showed beneficial potential of the plant to get commercially cultivated and get used for the natural drugs and medicine. The plant has been reported to have various pharmacological activities as antioxidants, analgesic, anti-inflammatory, anti-ulcer, anti-viral, immuno-modulatory, hepatoprotective, anti-diabetic, anti-colitis and anti-cancer...
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Posted by admin on Mar 31, 2018 in |
Probiotics are live microorganisms that confer many health benefits to the host when administered in adequate quantities. These health benefits have garnered much attention towards probiotics and have given an impetus to their use as dietary supplements for the improvement of general health and as adjuvant therapies for certain diseases. The increased demand for probiotic products in the recent times has provided the thrust for probiotic research applied to several areas of human biology. The advances in genomic technologies have further facilitated the sequencing of the genomes of such probiotic bacteria and their genomic analyses to identify the genes that endow the beneficial effects they are known to exert. This work reviews the application of genomic strategies on probiotic bacteria, while providing the details about the probiotic strains whose genome sequences are available. It also consolidates the genomic tools used for the sequencing, assembly and annotation of the probiotic genes and how it has helped in comparative genomic...
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Posted by admin on Mar 31, 2018 in |
In this article, we have reviewed several features of nanomicelles relating to their general properties, preparation and characterization techniques, and their applications in the areas of ocular drug delivery system. Nanomicelles can be rummage-sale as ‘smart drug carriers’ for targeting certain areas of the eye by making them stimuli-sensitive or by attachment of a specific ligand molecule onto their surface. In present scenario, the major challenge for the researchers is ocular drug delivery system as eye is the most sensitive organ in our body. Topical eye drop is the best suited way for delivery of drugs for the treatment of anterior segment of the eye. Delivery of the drugs to the targeted areas is restricted by the various barriers and even the amount instilled do not remain there for a long duration of time. In the past many years scientist are working on providing the masses the way for delivering drug in a novel, safe and patience compliance manner. The aided the basic delivery by providing the administration through...
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Posted by admin on Mar 31, 2018 in |
Amid the previous couple of years, the improvement of powerful, experimental innovations for treatment of cardiovascular arrhythmias has surpassed the pace at which itemized information of the basic science has aggregated. Cardiac arrhythmia is a group of conditions in which the heartbeat is irregular, either too fast, or too slow and is characterized by abnormal electrical conduction in the heart resulting in ineffective pumping heart rate and rhythm that is not physiologically justified. Cardiac arrhythmias are commonly classified as tachycardia (supraventricular or ventricular) or bradycardias. The specialist management of arrhythmias has changed significantly over the past decade. Abnormal impulse conduction results in reentrant excitation. Usually a combination of slowed conduction and unidirectional conduction block provides the conditions necessary for re-entry to occur. This article outlines current management strategies for atrial flutter and atrial fibrillation, with particular emphasis on curative strategies with catheter ablation and the recent data on rhythm compared with rate control strategies. The biology of arrhythmia is largely quantifiable, which allows for systematic analysis that could transform...
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