Posted by admin on May 31, 2017 in |
Up to 40% of new chemical entities (NCEs) discovered today by the pharmaceutical industry through combinatorial chemistry and high through put screening are highly lipophilic or poorly water soluble compounds, so the number of such compounds has dramatically increased and the solubility behaviour of these drugs has become one of the most challenging aspects in formulation development. So amongst the vast majority of strategies (like particle size reduction, use of surfactants, cosolvency, hydrotrophy etc) already reported in the literature to resolve this issue, solid dispersions have emerged as an advanced technique of improving the solubility/dissolution rate and hence, the bioavailability enhancement of a wide range of poorly water-soluble drugs. This review article mainly focuses on solubility ranges, biopharmaceutical classification system (BCS), list of poorly soluble drugs, commercial preparations, classification, types, advantages, limitations, methods of preparation and characterization of solid dispersions. In this review, besides above it is intended to discuss the recent advances and future prospects related to the solid dispersion...
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Posted by admin on Apr 30, 2017 in |
Natural pigments have great interest with in the market now a day’s particularly microbial pigments. The various microorganisms such as Micrococcus, Bacillus, Rhodotorula, Monascus, Phaffia, Sarcina and Achromobacter have the capability to produce different pigments. These colors have number of beneficial properties like anti-cancerous, immunosuppressive, antibiotic, anti-proliferative, bio-degradability etc. Further, they have broad area of application mainly in food, dairy, printing, textile and pharmaceutical industries etc. Since, the microorganisms are a significant source of carotenoids and major source of naturally occurring pigments. These carotenoids basically protect cells against photo oxidative damage and hence have vital applications in environment, food and nutrition, disease control, and as potent antimicrobial agents. Use of microbial pigments in processed food is another promising area with large economic potential. However, microbial pigments provide challenges due to lower stability, high cost and variation in shades due to changes in pH. Further, it is also essential to have toxicology studies of these microbial pigments before their use as natural colorants in food...
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Posted by admin on Apr 30, 2017 in |
Piperidine is a key structural motif in various alkaloids and a variety of compounds studied in medicinal chemistry. Though many methods have been developed for their construction, there is still need for noval approaches. Among the wide variety of heterocyclic compounds; piperidin-4-ones exhibit various biological activities. Synthesis and biological applications of piperidin-4-ones derivatives are outlined in this...
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Posted by admin on Apr 30, 2017 in |
Endodontic treatment is helpful in saving millions of teeth each year, but at present the focus has shifted towards regenerative approaches as an ideal form of therapy to treat diseased or necrotic pulp tissues. Regeneration of lost tissues has been known for a very long time, but their use in dentistry is gaining momentum. The growing understanding of biological regeneration has permitted the use of stem cells for regeneration and revascularisation 1. The dental pulp contains a small sub population of stem cells that respond against caries progression and also secrete factors that have the ability to induce revascularization of pulp 2. Stem cells re-search and scaffolding are the frequently used words in basic science pulp researches at present. Several techniques with their individual advantages, disadvantages and uses are being performed 3. In the past few years, many studies regarding stem cells and tissue engineering have been done giving rise to a separate branch called Regenerative Dentistry 4. Regenerative Endodontics uses the basic logic that the patient specific tissue...
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Posted by admin on Apr 30, 2017 in |
Nature always stands as a golden mark to exemplify the outstanding phenomena of symbiosis. Natural products from plant, animal and minerals have been the basis of the treatment of human disease. Capsicum plants belongs to the family Solanaceae and kingdom Plantae, consist of 27 species, and approximately 3000 varieties. Chili peppers are used worldwide in foods for their pungent flavor, aroma, and to prolong food spoilage. With capsaicin contents ranging from zero to millions of Scoville heat units, the different varieties offer a wide range of options for people all over the world. The aim of present review is to form a short compilation of the pharmacological and toxicological potentials of this multipurpose fruit. Capsicum, has been used as anti-inflammatory, anti-diabetic, anti-cancer, anti-ulcer, anticoagulant, analgesic, anti-arthritis, immuno-modulatory, memory enhancing, pain relief, hypocholesterolaemic, hypolipidemic, hepatoprotective and antimicrobial effects. It also cause irritation to mucous membrane, inflammation and neurotoxicity. It should not be used on open wounds or abrasions, or near the eyes. It has antagonistic effects on of α-adrenergic blockers,...
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