Posted by admin on Jun 30, 2017 in |
Cancer is a major public health burden in both developed and developing countries. It is an abnormal growth of cells in body that can lead to death and globally the numbers of cancer patients are increasing day by day. There are several medicines available in the market to treat the various types of cancer but no drug is found to be fully effective and safe. Herbal medicines have a vital role in the prevention and treatment of cancer. With advanced knowledge of molecular science and refinement in isolation and structure elucidation techniques, various anticancer herbs has been identified, which execute their therapeutic effect by inhibiting cancer-activating enzymes and hormones, stimulating DNA repair mechanism, promoting production of protective enzymes, inducing antioxidant action and enhancing immunity of the body. Plants have been used for treating diseases since time immemorial. More than 50% of modern drugs in clinical use are of natural products. In the present review, an attempt has been made to study the plants that have been used in the...
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Posted by admin on Jun 30, 2017 in |
Glaucoma is a disease of the optic nerve. Progressive damage of the optic nerve will causes irreversible reduction in visual acuity; it leads to visual field loss and blindness. The main treatment of glaucoma is the reduction of intraocular pressure. Current therapy involves frequent administration of eye drops which results in poor patient adherence and therapeutic outcomes. This review is focusing on to overcome these limitation by developing a novel nanoparticle cross-linked collagen shield for sustained delivery of suitable drug. The drug is incorporate into the shield and cross-linked by cross-linking agent with the help of Ultraviolet irradiation. Metal oxide nanoparticles is most suitable as cross-linking agent.e.g-polyvinylpyrrolidone (PVP) capped zinc oxide (ZnO/PVP).There is some evaluation parameter for nanoparticle cross-linked collagen shield like cytotoxicity as well as shield transparency. Cross-linked collagen shields characterise for their mechanical strength, swelling capacity and bioadhesive properties, ZnO/PVP NP cross-linked shields is the most favourable characteristics compare to plain film. It release drug over a period of 14 days offering a promising sustained release treatment...
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Posted by admin on Jun 30, 2017 in |
Dissolution of drug and its release from the dosage form have basic impact on bioavailability. Bioavailability depends on solubility of drug. Solubility is major challenge for the pharmaceutical industry with the developments of new pharmaceutical products. There are several approaches for solubility enhancement which includes micronization, Nanonisation, use of salt forms, use of surfactant, solid dispersion, and supercritical fluid recrystalization etc. Liquisolid technique is novel and efficient approach for solubility enhancement. According to this method the conversion of water insoluble drug into dry looking, non adherent, free flowing and acceptably compressible powder by incorporating into suitable non volatile solvents, carrier material and coating materials. This free flowing powder is than subjected to Preformulation studies like Fourier transformed infrared spectroscopy, differential scanning Calorimetry for compatibility studies , angle of slide, flow properties, solubility studies, calculation of liquid load retention potential, liquid load factor etc. These free flowing powders are subjected to compression for tablet or filled in capsules. The mechanism for solubility enhancement includes increase in wettability and surface of...
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Posted by admin on Jun 30, 2017 in |
Incompatibility is an undesirable reaction that occurs between drugs, excipients, or with container. This may be therapeutic, chemical and physical incompatibility. Fixed dose combination provides challenge in product development due to incompatibility of two drugs. So severe degradation of drug in presence of each other. Formulation and stability difficulties arise with incompatible combination. It involves interaction between two or more substances (drug-drug, drug-excipients, drug-excipients-drug interactions) which leads to change in colour, odour, taste, viscosity, and morphology. There are various approaches to overcome incompatibility. Among which the bilayer tablet is one of the suitable approach and increasing attention from a variety of industries for various reasons viz. Therapeutic and marketing attendance with the great physical, chemical and microbial stability. The purpose of this review is to study the physical incompatibility between fixed dose combinations, to find remedies that overcome the problems in designing formulation and to select best optimised approach to reduce incompatibility issue in fixed dose...
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Posted by admin on May 31, 2017 in |
Oral drug delivery is the most preferred route for the various drug molecules among all other routes of drug delivery, because ease of administration which lead to better patient compliance. So, oral extended release drug delivery system becomes a very promising approach for those drugs that are given orally but having the shorter half-life and high dosing frequency. Extended release drug delivery system which reduce the dosing frequency of certain drugs by releasing the drug slowly over an extended period of time. Oral sustained drug delivery system is complicated by limited gastric residence times (GRTs). To overcome these limitations, various approaches have been proposed to increase gastric residence of drug delivery systems in the upper part of the gastrointestinal tract. The purpose of writing this review was to compile recent literature on pharmaceutical approaches used in enhancing the Gastric Residence Time (GRT). Enhancing the GRT may explore new potentials of stomach as drug-absorbing organ. Several approaches are currently used including Floating drug delivery system, Matrix tablet, pulsatile drug delivery,...
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