Posted by admin on Oct 31, 2016 in |
Histone deacetylase inhibitors (HDACIs) are a group of agents that have exhibited antitumor activity in vivo and in vitro, directing to clinical trials estimating their efficacy in multiple cancer types. Belinostat is under global development with Spectrum Pharmaceuticals, currently approved by the U.S. Food and Drug Administration with indications for relapsed or refractory peripheral T-cell lymphoma on July 2014 and is under regulatory review in the Europe. Belinostat has been investigated as a single agent and in groups with further chemotherapies and biological agents, in the management of solid tumors and lymphoma. The main side effects are pyrexia, pneumonia, anemia, thrombocytopenia, neutropenia and fatigue, which are manageable. Belinostat is also being investigated in patients with bladder cancer, prostate cancer, solid tumor, mantle cell lymphoma, refractory advanced thymic epithelial tumors, pancreatic cancer and ovarian cancer. This article reviews the obtainable information on Belinostat with respect to its clinical pharmacology, mechanism of action, pharmacodynamics, pharmacokinetics, metabolism, preclinical studies and clinical...
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Posted by admin on Oct 31, 2016 in |
Hunteria is a genus of plant in family Apocynaceae. It comprises of 12 species but more prevalent are Hunteria umbellata and Hunteria zeylanica. Taditionally H. umbellata have been used in the treatment of yaws and sexually transmitted infections, stomach ache, ulcers, diabetes mellitus and dysmenorrhoea. H. zeylanica is used to cure profile but its prolonged use, particularly, at high doses should be with great caution. The phytochemical analysis of the H. stomach-ache, wounds and cuts. H. umbellata has a relatively low oral toxicity umbellata plant extract revealed the presence of saponins, steroids, tannins, volatile oils, phenols and copious amount of alkaloids. H. zeylanica leaves and stem bark prominently contains alkaloids. Scientific researchers have shown that H. umbellata and H. zeylanica were active against various diseases such as bacterial infections, pain, fever, inflammation, diabetes, in obesity, hyperlipidemia, heart problems, in child birth and malaria. Aim of the current review is to explore potential species of Genus Hunteria for ethnopharmacology, toxicological studies, safety, phytochemical investigation and pharmacological...
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Posted by admin on Oct 31, 2016 in |
The Process validation involves a series of activities over the lifecycle of the product and process. The FDA guidance described three stages of process validation which includes Process Design, Process Qualification, and Continued Process Verification (CPV). The CPV stage is a never ending approach that continues throughout the entire commercial lifecycle of the product. CPV is dependent on compliance with GMP principles and ensures that manufacturing process remains in a state of control. Establishment of Critical process parameters (CPP) and assessment of Critical quality attributes (CQA) of a product ensures robust manufacturing process and thereby improves productivity and desired quality. The product stability program, change control process & annual product review process serves as key drivers for monitoring process stability. Process analytical technology (PAT) applications such as near infra red spectroscopy, raman spectroscopy & multivariate statistical process control can be viewed as enablers for CPV. The primary goal of PAT is to reduce process variabilities that may impact CQA’s of a product. Continued Process verification is an effective quality...
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Posted by admin on Oct 31, 2016 in |
Zika virus is transmitted to people through aedes mosquito bites. People with Zika virus disease usually have symptoms of mild fever, exanthema (skin rash), joint pain and conjunctivitis that normally last for 2-7 days. There is no specific treatment or vaccine currently available. The best form of prevention is protection against mosquito bites. The virus is known to circulate in Africa, the Americas, Asia and the Pacific. The present paper deals with various modes of transmission, symptoms, diagnosis and preventive measures. A brief discussion about the role of various departments for control and prevention of zika virus. The available means for treatment of zika virus were also...
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Posted by admin on Oct 31, 2016 in |
The rhizosphere represents the thin layer of soil surrounding plant roots and the soil occupied by the roots, supports large active groups of microorganisms. The vast organic compounds (amino acids, sugars etc.) secreted by plant roots in the rhizosphere provide a food source for microorganisms increasing microbial biomass and their activity in the rhizosphere. Antibiotics are antimicrobial compounds produced by living microorganism as secondary metabolites. These compounds are used therapeutically and sometimes prophylactically in the control of infectious diseases. The isolation of antibiotics from microorganisms is relatively easy as compared to chemical synthesis of antimicrobial agents. The isolation of antibiotics from microorganisms improved the discovery of novel antibiotics that could act as better chemotherapeutic agents. With the increased population pressure, costs and side effects and the development of resistance of pathogens to drugs for infectious diseases, there is an urgent need to explore microbes for development of new antimicrobial metabolites. As microorganisms grow in unique and extreme habitats, they may have the capability to produce unique and unusual metabolites....
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