Posted by admin on Mar 31, 2017 in |
The present review is, therefore, an effort to give a detailed survey of the literature on its pharamacognosy, phytochemistry, traditional uses and pharmacological studies of the plant Dalbergia sissoo. The genus consists of 300 species among which 25 species occur in India. The generic name Dalbergia honors the Swedish brothers Nils and Carl Dalberg, who lived in the 18th century. Dalbergia sissoo is an important timber species around the world. Besides this, it has been utilized as medicines for thousands of years and now there is a growing demand for plant based medicines, health products, pharmaceuticals and cosmetics. Dalbergia sissoo is a widely growing plant which is used traditionally as anti-inflammatory, antipyretic, analgesic, anti-oxidant, anti-diabetic and antimicrobial agent. Several phytoconstituents have been isolated and identified from different parts of the plant belonging to the category of alkaloids, glycosides, flavanols, tannins, saponins, sterols and terpenoids. A review of plant description, phytochemical constituents present and their pharmacological activities are given in the present...
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Posted by admin on Mar 31, 2017 in |
Inflammation is the local defensive response of living tissues to injury or due to any other chemical agents. Inflammation consists of two basic processes early inflammatory response later followed by healing. There are two types of inflammation, acute and chronic. The different animal models (i.e. vascular permeability, UV-erythema in guinea pigs, Croton-oil ear edema in rats and mice, Paw edema in rats, Collagen Induced Arthritis, Adjuvant Induced Arthritis, and Papaya Latex Induced Arthritis) are used for evaluation of anti-inflammatory activity for pre clinical study. Animal models of inflammation are used to study pathogenesis of ailments and to evaluate potential anti-inflammatory drugs for clinical use. This review article addresses the inflammatory characteristics and similarities between varieties of animal models of...
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Posted by admin on Mar 31, 2017 in |
As time passes more and more poorly water soluble drug are being discovered. Formulating these drugs in to amorphous solid dispersion is an effective strategy to deliver poorly water soluble drugs. Spray drying is one of common and a well-established manufacturing technique which can be used to formulate amorphous solid dispersions (ASDs). However, the spray drying is complex phenomenon and the spray drying process parameters yield the ASD with specific characteristics. Various diverse factors interact in an inter-dependent manner to determine the final product properties. This review discusses the basic background of spray drying, and various aspects of spray drying such as instrumentation, thermodynamics, drying kinetics, particle formation process and scale-up challenges are included. Recent advances in the spray-based drying techniques are mentioned along with some future avenues where major research is...
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Posted by admin on Mar 31, 2017 in |
Scavenger receptor class B member 1 also known as SR-B1 is a receptor that in human is encoded by the SCARB1 gene. SR-B1 functions as a receptor for high density lipoprotein. SR-B1 receptor is mostly found in liver and is best known for its role in facilitating the uptake of cholesteryl ester from HDL in liver. This movement of cholesterol is known as reverse cholesterol transport. Cancerous cells generally have high requirement for cholesterol as they are rapidly dividing cells. HDL acts as carrier for cholesteryl esters and triglycerides. The high affinity of cancer cells for HDL has made HDL useful as carrier for delivering anti-cancer drugs into cancerous cells. So synthetic rHDL particles are designed as carrier for anti-cancer drug owning to their structural features, biocompatibility and targeting capability via receptor mediated mechanism due to which cytotoxic effect of cancer chemotherapeutic drugs on healthy organs can be significantly diminished by employing rHDL as carrier. Drugs incorporated into rHDL were 2.5-23 times cytotoxic to cancer cell than the free...
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Posted by admin on Mar 31, 2017 in |
Asthma is a chronic obstructive disease of airways affecting bronchi, resulting in bronchoconstriction, tightening of chest and airway inflammation. Asthma remains a disease with clearly unsatisfactory therapeutics. With the mounting evidence in support of asthma being an inflammatory illness, anti-inflammatory agents have now become prerequisite for the long-term management of asthma. Along with anti-inflammatory agents, there is a need to search for other effective therapies to treat every aspect of the disease. The present review gives an insight of various approaches available for the management of asthma. A number of drugs are available with chemical diversity as on date for the treatment of bronchospasmolytic conditions. The different sites or receptor involved in this intervention is adrenoceptor, steroid receptor, phosphodiesterase and many more. The agents such as β-agonist, antihistaminics, anticholinergics and inhalation steroids, only treat symptoms and do not cure the underlying inflammation. On the other hand, adenosine receptor modulators, selective PDE4 inhibitors, leukotriene modifiers and lipoxygenase inhibitors represents other therapeutic interventions with more targeted control by acting on different...
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