Posted by admin on Jul 31, 2016 in |
Oral route of drug delivery is the simplest and most accepted way of administration of drugs due to greater stability, high patient compliance, accurate dosage, cost effectiveness and high patient compliance of drugs. But with oral formulations bioavailability is the major problem for newly discovered drug because 40 percent are lipophilic compounds. There are several factors responsible for low oral absorption of hydrophobic drugs and one very particular one is poor absorption due to slow and/or incomplete drug dissolution and precipitation in the gastro-intestinal lumen or other aqueous media. Therefore in order to be delivered orally and to achieve acceptable bioavailability, lipophilic drugs require a co-administered drug delivery system. This article mainly gives overview of technologies available with special emphasis on mechanism of SEDDS and potential for commercialization of formulation as compared to other technologies along with examples. But there are certain disadvantages of SEDDS like lack of good predicative in vitro models for assessment of the formulations and higher concentrations of surfactant used may cause some allergic reactions....
Read More
Posted by admin on Jul 31, 2016 in |
Nigella sativa seed is one of the spices, which is referred by Prophet Mohammed as a herb of blessing, which can cure everything other than death. Therapeutic potential of Nigella sativa seed has been very well studied by many researchers, but its use in cosmetic science is not very well studied. Nigella sativa seed is intensively studied for its chemical composition. It is reported to contains Thymoquinone, Nigellimine-N-oxide, Nigellicine, Nigellidine, Nigellone, Dithymoquinone, Thymohydroquinone, Thymol, Arvacrol, 6-methoxy-coumarin, 7-hydroxy-coumarin, Oxy-coumarin, Alpha-hedrin, Steryl-glucoside, Tannins, Flavinoids, Essential fatty acids, Essential amino acids, Ascorbic acid, Iron and calcium. Presence of these natural actives makes Nigella sativa seed as great medicinal herb. Nigella sativa seed has antimicrobial, antioxidant, anti-aging, hair growth promoter, sun protection, anti cancer activity, which make it a novel ingredient for many cosmetic preparations. This review brings the comprehensive compilation of researches on Nigella sativa seed in the area of cosmetics and related...
Read More
Posted by admin on Jul 31, 2016 in |
Diabetes mellitus is the common metabolic disorder seen in 2.8% of the world’s population. It is expected to cross 5.4% by 21st century. It is one of the causes of death in this 21st century. Since many years, herbal medicines are used as a source of medicine in Ayurveda and also in some traditional systems of medicine. Ayurveda and other traditional systems have textual evidence about the uses of medicinal plants to cure various types of diabetes in human beings. Thousands of plant species has shown the therapeutic efficacy to control diabetes. As the usage of natural medicinal plants can have lesser side effects when compared with the synthetic drugs. This review mainly aims to know about various plant species in India and all around the world that are used in curing Diabetes...
Read More
Posted by admin on Jul 31, 2016 in |
Statins, 3-hydroxymethyl-3-methylglutaryl coenzyme A reductase inhibitors, are considered safe in lowering hyperlipidemia and cardiovascular disease. Statin attempt to reduce cholesterol production in liver in dose dependent manner not only cause the muscle related problem but also leads to other untoward consequence like arthritis, diabetes, neurological disorders which arise as a result of scarcity in cholesterol production. Discontinuation or reduction in the dose of the statin usually leads to resolution of these side effects but the efficacy is questionable. Though the statin had come to market several decades ago, their harmful effects have been well understood very recently only after several randomized trials. The pleiotropic effects of statin have reported many benefits, but lack of randomized clinical trials make it limit to extend its indication beyond lipid lowering effects. There is still a controversy between their benefits and adverse effects of statin. The upcoming research should focus to resolve the above said confliction that could overcome its most adverse events- myopathy. If it so the statin with pleiotropic effect without...
Read More
Posted by admin on Jul 31, 2016 in |
Nanosized fluorescent carbon particles, carbon dots (CDs), are a kind of fluorescent material that has many applications in recent years. They have biological application like delivery of therapeutic payloads for cancer therapy mainly due to their biocompatibility and unique optical properties. Fluorescent carbon dots overcome the short comings of high toxicity of traditional nano materials. Moreover, the preparation procedure of fluorescent carbon dots is simple and easy. Therefore, fluorescent carbon dots have great potential applied in photocatalysis, biochemical sensing, bioimaging, drug delivery and other related areas. Many functional groups or passivation agents are used to cover the surface of the CDs outside the carbon core, to make CDs with high quantum yield (QY), chemical stability and good water solubility. CDs can be easily conjugated with target molecules to expand their functionality. These traits make them an ideal alternative to semiconductor quantum dots such as CdTe and CdSe. Amoung multi-coloured fluorescent carbon dots, green CDs(GCDs) shows high potential in biological labelling and...
Read More
