Posted by admin on Jan 31, 2016 in |
Aim: This article focuses on the current review of world-wide medicinal plants studied for their phytochemical investigations, various biological activities and clinical studies in relation to their use for treatment of Sickle cell disease. Method: All relevant literature databases were searched up to 18 September 2014. The search terms were plant, herb, herbal therapy, phytotherapy, sickle cell anemia and antisickling agent. All of the human, animal, in vitro studies, and reviews were included. Antisickling agent, antioxidant, and ethnopharmacological effects were the key outcomes. Results: In vitro and in vivo studies in various herbs revealed that anthraquinones, anthocaynin, amino acids, caricapinoside, p-hydroxy benzoic acid etc. are the potent herbal constituents responsible for antisickling activity in sickle cell anemia patients and these herbal constituents can be further researched for development of a much safer and affordable medicine in future. Conclusion: This extensive literature review indicated the presence of large number of medicinal plants and their phytochemical constituents that can be of great interest for further research in search of the therapeutically...
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Posted by admin on Jan 31, 2016 in |
Drug release from novel drug delivery systems are desired to be controlled at target site in effective concentration for required therapeutic action with predictable plasma concentrations, unlike conventional ones, thereby reducing the dose, dosage frequency, toxic adverse effects, reduction of blood level fluctuations, improved patient compliance and minimization of drug accumulation. As this can be achieved by the phenomenon called osmosis, osmotic pump drug delivery systems are proved as one of the most promising oral drug delivery systems in the recent times. They are tablets coated with semipermeable membrane which causes pores in water and desired drug release occurs. Drug delivery from this system is not influenced by the different physiological factors within the gut lumen and the release characteristics can be predicted easily from the known properties of the drug and the dosage form. In the present review, a summary of the collected information on the osmotic drug delivery system has been discussed in...
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Posted by admin on Jan 31, 2016 in |
Administration of drug by oral route is the most effective and acceptable route as it has better therapeutic efficacy, low cost and good patient compliance. More than 40% of new drugs are poorly water soluble. These drugs present development challenges and also have poor bioavailability. Although many formulation approaches like solid dispersions, complexation, pH modification exist, novel lipid based drug delivery system is best approach to design formulation with increased therapeutic benefit for poorly water soluble drug. This review provides recent updates on lipid based drug delivery system with main focus on self micro-emulsifying drug delivery system. Self-microemulsifying formulations are evident to improve the oral bioavailability of hydrophobic drugs due to their efficiency in presenting the hydrophobic drug in solubilized form whereby dissolution process can be circumvented. Oil, surfactant and co-surfactant also contribute to the overall improvement in oral bioavailability via promoting the lymphatic transport; thereby hepatic first pass metabolism can be...
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Posted by admin on Jan 31, 2016 in |
Pomegranate, Punica granatum L. (Punicaceae), as a medicinal and nutritional ancient fruit, has an outstanding medical history throughout the world. Each of compartments of pomegranate has interesting pharmacological activity. Juice, leaf, flower, and peels of pomegranate possess potent antioxidant properties, while juice, peel and oil are all weakly estrogenic activity. Pomegranate seeds have ethnomedical indication and high conjugated α-linolenic acids (CLn) contents. Pomegranate seed oil (PSO) with high amount of punicic acid (PA), a conjugated isomer of α-linolenic acid, has variety of pharmacological properties. The main properties are as follows; antioxidant, anti-inflammatory, nephroprotective, hepatoprotective, neuroprotective, anti-cancer, enhancing the immune system, enhancing carbohydrate metabolism and reducing insulin resistance. Based on some studies, effects of PSO on lipid profile are controversial and consistency of data is rare to find yet. Therefore, this review is aimed to highlight the PSO’s composition and beneficial effects on human health and represent the mechanisms involved in its...
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Posted by admin on Dec 31, 2015 in |
Herbal medicine, rather than merely curing a particular disease, aims at returning the body back to its natural state of health. Vitex negundo Linn. known as Sambhalu in Unani medicine belongs to family Verbenaceae. It is a large aromatic shrub distributed throughout India. It has been used since ancient times as a female remedy in Unani medicine. It is a well known plant because of its two main properties i.e. its use in female disorders specially disorders linked with female reproductive system and decreasing sexual desire. It is also used in other problems like roots and leaves used in eczema, ringworm and other skin diseases, liver disorders, spleen enlargement, rheumatic pain, gout, abscess, backache; seeds used as vermicide. It is also used to control population. This review is an attempt to highlight its therapeutic uses especially in females mentioned in Unani medicine as well as phytochemical and pharmacological...
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