Posted by admin on Jun 30, 2016 in |
Biomaterials can be thought as the key ingredients in several implants such as those used for joints, sutures, bone plates, and medical devices such as blood tubes, artificial heart, pacemakers, etc. They function by replacing, restoring the injured or destroyed tissues or organs, and thereby help in providing better essence of life of the patients. A biomaterial which is used in making implants should contain some important desirable properties for long term usage in the body without being itself rejected. They are grouped in four different classes as Metals, Polymers, Ceramics, and Composites which can be used singly or in combination with each other to form most of the commercially available medical devices and implants. In this review we have summarized the importance of biocompatibility and the application of biocompatible materials in various fields of sciences and healthcare...
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Posted by admin on Jun 30, 2016 in |
Herbs & its formulations have a long history of use in the treatment of human diseases. Herbal extracts have long been regarded as a source of new and useful pharmaceuticals. According to Cragg’s investigation, approximately 62 % of commercially available drugs have natural product origins. Manjistha, or Rubia Cordifolia to give it its scientific name, is a branched climber with small, greenish white flowers that are arranged in a cluster of round, fleshy, purple fruits. Its roots have a brownish red bark from which a red dye is obtained. This plant grows well in hilly districts, and the root has medicinal values. Manjistha is considered to be one of the most valuable herbs in Ayurveda, the world’s oldest health care system that originated in India. The ancient physician and sage, Charaka has categorized the herb as varnya or that which improves the complexion, jvarahara, or that which reduces fever, and visaghna or that which detoxifies. It is also a well known rasayana – a rejuvenative. Another great sage, Sushruta has...
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Posted by admin on Jun 30, 2016 in |
In this review our main focus is on flavonoid groups which are one of the main active constituents found with other active constituents like saponins and polysaccharides, while poisonous groups are nitro-compounds, indolizidine alkaloids and the seleniferous derivatives in Astragalus genus. It is well established fact that flavonoid possess many biological activity such as antiallergic, anti-inflammatory, antitumor, antiviral, antioxidant anticancer including anticarcinogenic and prodifferentiative activities. Many flavonoids, including those which are phytoalexins, provide plants with a defense against viral infections. The estrogenic action of many isoflavones is well known and mixtures of flavonoids are commonly used commercially to reduce capillary fragility. Astragalus root is a very old and well known drug in traditional Chinese medicine and have been used to improve resistance to infections and to aid in immunological disorders and viral infections, and also used as hepatoprotective, heart tonic, nephritis and diabetes. This review reports all flavonoids isolated till date which is nearly about 131 from 60 species of Astragalus genus; these flavonoid are further characterized and classified...
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Posted by admin on May 31, 2016 in |
Bioanalytical method development is the process of creating a procedure to enable a compound of interest to be identified and quantified in a biological matrix. A compound can often be measured by several methods and the choice of analytical method involves many considerations. Analysis of drugs and their metabolites in a biological matrix is carried out using different extraction techniques like liquid-liquid extraction, solid phase extraction (SPE) and protein precipitation from these extraction methods samples are spiked with calibration (reference) standards and using quality control (QC) samples. These methods and choice of analytical method describes the process of method development and includes sampling, sample preparation, separation, detection and evaluation of the results. The developed process is then validated. These bioanalytical validations play a significant role in evaluation and interpretation of bioavailability, bioequivalence, pharmacokinetic, and toxicokinetic studies. In which different parameters like accuracy, precision, selectivity, sensitivity, reproducibility, and stability are...
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Posted by admin on May 31, 2016 in |
The use of nanoparticles as drug delivery and targeting agents has led to immense progress in the field of biomedicine and diagnostics. Likewise gold nanoparticles can be conjugated with various molecules, for instance, to plasmid DNA for gene therapy, to various drugs for antibacterial and anticancer properties, to several antibiotics and peptides for immunological and diagnostic purposes. The review encompasses various fields in which the gold nanoparticle conjugates have emerged as a promising tool for effective therapeutics and diagnosis. The article addresses a brief knowledge about the subject available to readers about various gold nanoparticle conjugates that have been researched. Although more work is needed to establish the toxicity concerns yet these particles have proved to be a promising therapy for the diagnosis and treatment of various diseases, especially cancer. With the cancer cells becoming resistant to anti-cancer drugs, the use of gold nanoparticles for the enhanced delivery and increased action of anti-cancer drugs has paved a new way to battling against...
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