Posted by admin on Aug 31, 2015 in |
Elytraria acaulis Lindau, Acanthaceae (Family), also known as the Asian scalystem places itself an important position in the history of Indian system of medicine. It is found throughout Nigeria, Angola,Ghana, Uganda, Kenya, Botswana, Malawi, Mozambique, Zambia, Zimbabwe, Tanzania, South Africa, Somalia and India. Indian ayurveda explored in treating several ailments by using natural products derived from the medicinal plants. Using synthetic drugs to cure many diseases are adversely affecting immune system of the body. E.acualis is extensively used in the treatment of diabetes, diarrhoea and worm infections. It exhibits anti inflammatory, anti oxidant, anti hyperglycemic and anti fertility activities. In olden days the roots were made into paste and were topically applied for the treatment of leucorrhoea, snake bite and piles. This present study depicts the phytochemical and the pharmacological profile of Elytraria acaulis...
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Posted by admin on Aug 31, 2015 in |
SLN is a challenging field of nanotechnology notified in the recent years. It has been proved that SLN is more beneficial colloidal drug delivery system because of its more controlled and targeted properties. Recent advances in nanotechnology has indicated unimaginable guarantee to adjust disease therapeutics by creating new treatment modalities which may permit better focused delivery of anticancer medications to destroy dangerous cells in different malignancies. Due to their unique size dependent properties, lipid nanoparticles offer possibility to develop new therapeutics. Parts of SLN stability and the influence of different excipients (utilized as a part of SLN creation) on stability with other optional steps included in their adjustment like freeze drying, spray drying and so on. Issues connected with SLN creation and instrumental strategies utilized as a part of generation are altogether talked about. This review discuses on many aspects of SLN such as its structure, aim, advantages disadvantages, method of sterilization, method of preparation, principle of drug release , route of administration and Its medicinal applications. Study of...
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Posted by admin on Aug 31, 2015 in |
One of the major advances in vesicle research was the finding that some modified vesicles possessed properties that allowed them to successfully deliver drugs in deeper layers of skin. Transdermal delivery is important because it is a noninvasive procedure for drug delivery. Further, problem of drug degradation by digestive enzymes after oral administration and discomfort associated with parenteral drug administration can be avoided. An alternative approach to overcome the low oral bioavailability is to administer the drug by non oral routes such as buccal, nasal, vaginal, transdermal and parenteral. Among the above routes the transdermal delivery of ethosome is advantageous. Because it has good penetrability, ease of administration, rapid termination of the therapy and administrating to unconscious patients. Ethosome mainly contain phospholipids with higher concentration of ethanol. It can be used for systemic delivery of drug. It is beneficial to overcome the problem of frequent dosing due to shorter half-life of drugs. Prolonged release of the drug and increased bioavailability leads to significant reduction in the dose and hence...
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Posted by admin on Aug 31, 2015 in |
Seasonal fluctuations are periodical series, and have impact on availability of active principles in medicinal plants hence, therapeutic efficacy also get influenced. The survey of several scientific studies published in scientific journals of international repute indicates this fact. The studies reported that essential oil component shows a rhythmic increase in oil production throughout the growing season and then a steady decline towards the winter hence, recommended late summer as the best collection time. In contrast other researchers concluded the winter as a best season for harvesting of essential oils containing plant parts. It is not only essential oil that influenced by the season but other important constituents like polyphenol, flavonoids, glycosides, alkaloids etc are also influenced significantly by seasons. There is no general rule for the harvesting time for better yield of specific secondary metabolites. Although several studies have been published indicating the effect of seasons on secondary metabolites but there is no compiled information representing the optimized season for the collection of pharmaceutically important constituents from different plant...
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Posted by admin on Aug 31, 2015 in |
Pulsatile drug delivery systems are developed to deliver drug according to circadian behavior of diseases. The product follow a sigmoidal drug release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Thus drug can be delivered at right time, in right amount and at right site of action by use of such approach. The potential benefits of chronotherapeutics have been investigated and established for number of diseases like asthma, arthritis, cancer, diabetes, epilepsy, hypertension, ulcer, hypercholesterolemia etc. Various capsular, osmotic, single and multiple unit systems that are modulated by soluble or erodible polymer coatings, rupturable membranes are available in market. These systems are beneficial for diseases showing chronopharmacological behavior where night time dosing is required or for the drugs having high first pass effect or having site specific absorption in GIT, or for drugs with high risk of toxicity or tolerance. These systems also improve patient compliance by decreasing dosing...
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