Posted by admin on Jan 31, 2016 in |
Administration of drug by oral route is the most effective and acceptable route as it has better therapeutic efficacy, low cost and good patient compliance. More than 40% of new drugs are poorly water soluble. These drugs present development challenges and also have poor bioavailability. Although many formulation approaches like solid dispersions, complexation, pH modification exist, novel lipid based drug delivery system is best approach to design formulation with increased therapeutic benefit for poorly water soluble drug. This review provides recent updates on lipid based drug delivery system with main focus on self micro-emulsifying drug delivery system. Self-microemulsifying formulations are evident to improve the oral bioavailability of hydrophobic drugs due to their efficiency in presenting the hydrophobic drug in solubilized form whereby dissolution process can be circumvented. Oil, surfactant and co-surfactant also contribute to the overall improvement in oral bioavailability via promoting the lymphatic transport; thereby hepatic first pass metabolism can be...
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Posted by admin on Jan 31, 2016 in |
Pomegranate, Punica granatum L. (Punicaceae), as a medicinal and nutritional ancient fruit, has an outstanding medical history throughout the world. Each of compartments of pomegranate has interesting pharmacological activity. Juice, leaf, flower, and peels of pomegranate possess potent antioxidant properties, while juice, peel and oil are all weakly estrogenic activity. Pomegranate seeds have ethnomedical indication and high conjugated α-linolenic acids (CLn) contents. Pomegranate seed oil (PSO) with high amount of punicic acid (PA), a conjugated isomer of α-linolenic acid, has variety of pharmacological properties. The main properties are as follows; antioxidant, anti-inflammatory, nephroprotective, hepatoprotective, neuroprotective, anti-cancer, enhancing the immune system, enhancing carbohydrate metabolism and reducing insulin resistance. Based on some studies, effects of PSO on lipid profile are controversial and consistency of data is rare to find yet. Therefore, this review is aimed to highlight the PSO’s composition and beneficial effects on human health and represent the mechanisms involved in its...
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Posted by admin on Dec 31, 2015 in |
Herbal medicine, rather than merely curing a particular disease, aims at returning the body back to its natural state of health. Vitex negundo Linn. known as Sambhalu in Unani medicine belongs to family Verbenaceae. It is a large aromatic shrub distributed throughout India. It has been used since ancient times as a female remedy in Unani medicine. It is a well known plant because of its two main properties i.e. its use in female disorders specially disorders linked with female reproductive system and decreasing sexual desire. It is also used in other problems like roots and leaves used in eczema, ringworm and other skin diseases, liver disorders, spleen enlargement, rheumatic pain, gout, abscess, backache; seeds used as vermicide. It is also used to control population. This review is an attempt to highlight its therapeutic uses especially in females mentioned in Unani medicine as well as phytochemical and pharmacological...
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Posted by admin on Dec 31, 2015 in |
Over the past few decades, the pursuit and exploration of nanotechnology is likely to have a significant impact on the drug-delivery system. This technology can be envisioned as playing a major role in revolutionizing the future of novel drug delivery system. Nanoparticles (NPs) are one of them which have many potential applications in clinical medicine and research. The encapsulation of therapeutic drugs in the form of nanoparticles shows advantageous effect over their corresponding drugs such as increases drug efficacy, specificity, tolerability and therapeutic index. The current review article focuses on the different nanoparticulate drug-delivery systems including nanoerythrosomes, Superparamagnetic nanoparticles, liposomes, Quantum dots, ceramic nanoparticles and dendrimers as well as their applications in different...
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Posted by admin on Dec 31, 2015 in |
objectives: Nelumbo nucifera Gaertn (Nelumbonaceae) known by numerous common names including Indian lotus, sacred lotus, bean of India, or simply lotus is one of the most important medicinal plants. In this review there is discussion about therapeutic potential of the different parts of the plant (leaves, seeds, flower, and rhizome) which can be used in traditional system of medicine. This review also describes various compounds isolated from different parts of the plant and therapeutic benefits derived from those phytocontituents. The aim of this review is to summarize the pharmacological, phytochemical and therapeutical knowledge of Nelumbo nucifera Gaertn. Key findings: The pharmacological studies have shown that N. nucifera possesses various pharmacological activities like anti-ischemic, antioxidant, anticancer, antiviral, antiobesity, lipolytic, hypocholestemic, antipyretic, hepatoprotective, hypoglycemic, antidiarrhoeal, antifungal, antibacterial, anti-inflammatory and diuretic activities. Several different types of compounds have been derived from this plant belonging to different chemical groups, including alkaloids, flavonoids, glycosides triterpenoid, etc., with own therapeutic impact. So the pharmacological effects and various active ingredients of different parts of N. nucifera...
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