Posted by admin on Nov 30, 2015 in |
This review article is focused at highlighting the therapeutic values of phytochemicals derived from the natural herbs ginger, garlic and tulsi. It is shown that the phytochemicals derived from these natural herbs work synergistically and exert similar pharmacological profile. The main actions include antioxidant and anti-inflammatory properties. Recommendations are made to follow the antioxidant status at the molecular level. A dietary supplement containing a mixture of 6-gingerol, 6-shogaol, 6-paradol, allicin, ajoene, eugenol and eucalyptol is highly recommended for the ageing patients. There is scope for deriving a common pharmacophore leading to the development of a good anti-inflammatory molecule with reduced side effects which may be beneficial for the elderly with multiple disorders. Information regarding the pharmacological effects and various targets of these phytochemicals has been compiled in the form of tables to provide easy reference for future...
Read More
Posted by admin on Nov 30, 2015 in |
In situ forming polymeric formulations are drug delivery systems that are in sol form before administration in the nasal cavity, but once administered, undergo gelation in situ, to form a gel. The formation of gel depends on factors like temperature modulation, pH change, presence of ions and ultra violet irradiation, from which the drug gets released in a sustained and controlled manner. In the recent years, nasal route has been identified as promising drug delivery route for systemic therapy. Mucoadhesive in situ gel formulations have demonstrated increase in the residence time in the nasal cavity as well enhancement of the permeation characteristics of the drug. The in situgel forming polymeric formulations offer several advantages like sustained and prolonged action in comparison to conventional drug delivery...
Read More
Posted by admin on Oct 31, 2015 in |
The safe use of medicines is a critical issue for all health care professionals, Background: Cancer refers to a group of diseases that are associated with a disturbance in the control of cell growth and metabolism. Indeed, the unbalanced control of cellular proliferation is a primary characteristic of cancer cells and, as such, any molecule capable of inhibiting cancer cell proliferation may also be useful as a potential chemo-preventive agent. Throughout history, antioxidants have been the most significant source of anticancer and chemopreventing agents. More than 1,000 different phytochemicals are already proved to possess interesting chemopreventing activities. Antioxidants consist of a wide variety of biologically active phytochemicals including phenolics, flavonoids, carotenoids, etc. that have been shown to suppress early and late stages of carcinogenesis. Objective: To review recent biochemical and molecular mechanisms, in relation to natural and synthetic chemopreventing substances (antioxidants) for cancer control and management. Major findings: Antioxidants exert anticancer effects via a variety of mechanisms, including removal of carcinogenic agents, modulation of cancer cell signaling and cell...
Read More
Posted by admin on Oct 31, 2015 in |
Colour is a molecule that absorbs certain wavelengths of visible light and transmits or reflects others whereas colourant is the activity of that molecule. Natural food colour is any dye, pigment or any other substance obtained from vegetable, animal, mineral, or source capable of colouring food drug, cosmetic or any part of human body, colours come from variety of sources such as seeds, fruits, vegetables, algae, and insect. Natural colour exists in their normal habitat at extremely low concentrations and as a result their extraction is expensive and highly sensitive to change.. Colour as a way to identify a food and a way to judge the quality of a food. Food colours come in many forms consisting of liquids, powders, gels and pastes. Food colouring is used both in commercial food production and in domestic cooking. Due to its safety and general availability, food colouring is also used in a variety of non-food applications including cosmetics, pharmaceuticals, home craft projects and medical...
Read More
Posted by admin on Oct 31, 2015 in |
Diabetes is a complex and multifarious group of disorders characterized by hyperglycemia that has reached epidemic proportions in the present century. Several drugs such as biguanides and sulfonylureas are presently available to reduce hyperglycemia in diabetes mellitus. These drugs have side effects and thus searching for a new class of compounds is essential to overcome these problems. Management of diabetes without any side effects is still a challenge to the medical community. There is continuous search for alternative drugs. Therefore, it is prudent to look for options in herbal medicine for diabetes as...
Read More
