Posted by admin on Nov 1, 2014 in |
One of the prime candidates in the treatment of debilitating human cancers includes a family of enzymes referred to as L- glutaminases. The antitumor activity of these enzymes found effective in countering Acute Lymphoblastic Leukemia (ALL a commonly diagnosed pediatric cancer.). Further it is found to inhibit four human tumour cell lines namely Hep-G2 [Human hepatocellular carcinoma cell line], MCF-7 [Breast cancer cell line], HCT-116 [Colon cell line] and A549 [Human lung Carcinoma]. Apart from therapeutic use, it is having a number of other applications like in food industry, analysis and in production of fine chemicals. This review, hence, mainly focuses on the biochemical aspects of L-Glutaminase production, aiming to comprehend the physiochemical characteristics, application of L-Glutaminase and its properties. Processes central to these biochemical aspects, including submerged fermentation and Solid state fermentation of L- glutaminase producing organisms are also...
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Posted by admin on Nov 1, 2014 in |
Heterocylic chemistry have been known for many years but in recent years heteocyclics received great attention. In heterocyclic chemistry oxazoline is one of the most important moiety. Oxazoline moiety shows a wide range of application such as in agriculture industry, pharmaceutical, food industry, natural product, medicine, polymers and various other industries. Oxazoline moiety constitutes the core structure of many biologically active natural compounds. Oxazoline play a major role in medicinal chemistry. Heterocyclic compounds whose containing oxazoline moiety as core structure reported wide range of biological activities such as antibacterial, antifungal, antimicrobial, antioxidant, antipyretic, anti-HIV, anti malarial, anti tumour, anti viral, anti-inflammatory, CNS stimulant activity etc. Oxazolines synthesized by the reaction of various aromatic substitutes like acids, aldehydes, nitriles, azides etc. Synthetic chemist do great work on the synthesis and application part of oxazolines. In this review we have described various synthetic methodologies and their different biological activities reported by organic synthetic...
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Posted by admin on Oct 1, 2014 in |
Gefitinib is an epidermal growth factor receptor tyrosine kinase inhibitor, a promising anticancer agent for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC), especially in EGFR mutated patients. It acts by interfering with the proliferation and survival of cancer cells and other host-dependent process promoting cancer cell growth by blocking signal transduction pathways. The major advantage of Gefitinib over standard chemotherapy is that it selectively inhibits cellular pathways involved in tumor survival with minimal effect on normal cells. Gefitinib was the first agent to be tested in clinical trials among tyrosine kinase inhibitors class of anticancer drugs. Gefitinib is a very slightly soluble novel anticancer drug whose solubility and dissolution can be improved by its complexation with cyclodextrins. Gefitinib is a generally well-tolerated treatment, with skin rash and diarrhea being the most common treatment adverse effects. Gefitinib has the potential of stimulating cell immunity against malignant cells. Binding of Gefitinib to human plasma protein is extensive. This article reviews the safety and efficacy of Gefitinib...
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Posted by admin on Oct 1, 2014 in |
Cancer is a very complex genetic disorder that is mainly caused by carcinogens. Carcinogens can be present in the air, water, food, chemicals, and sunlight that are exposed to the people. In the case of leukemia, the body produces large numbers of abnormal white blood cells. In the study of blood cancer that is leukemia, blood disorders through visual inspection of microscopic images of blood cells is an important diagnostic tool. From the identification of blood disorders, it can lead to the classification of certain diseases related to blood. Doxorubicin drug most useful for cancer treatment such as Breast cancer, ovarian cancer, Lung cancer, Neuroblastoma cancer, Leukemia, etc. In breast cancer, the efficacy of drug treatment will thus depend on the histology of the tumor tissue. In ovarian cancer, the doxorubicin metabolites accumulated in the ascites and cleared more slowly from the peritoneal compartment than from the serum. Accumulation in the peritoneal cavity with prolonged half-life should be considered when administering medication in patients with ascites. In lungs cancer,...
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Posted by admin on Oct 1, 2014 in |
Plants have played an important role as various medicinal agents since ages. Medicinal herbs have been used in one form or another, under indigenous systems of medicine like Ayurveda, Siddha, and Unani. The knowledge of Indian medicinal plants and their uses in the Ayurvedic and Unani system of medicine have led to many scientific investigations and researches throughout the world. Asthma is a common disease that is rising in prevalence worldwide with the highest prevalence in industrialized countries. Asthma affects about 155 million people worldwide, and it has been estimated that is further 100 million will be affected by 2025. It has affected 14-15 million people in the United States, including an estimated 4.8 million childhoods. It accounts for about 11 million hospital visits annually and the sixth most frequent reason for visits in the ambulatory setting. It the past decade’s research has been focused on scientific evaluation of traditional drugs of plant origin for the treatment of various diseases. Since the time immemorial, various herbs are used as...
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