Posted by admin on Jul 31, 2014 in |
This paper is specifically designed to explain the important scientific points of Polymerase Chain Reaction (PCR) technology in forensic science and molecular biology. Scientific procedures presented in the paper are complex, simple were specifically designed to better explain and reinforce the key concepts of PCR. The PCR is a laboratory technique for amplifying a specific sequence of a minute amount of Deoxyribonucleic acid (DNA) even from a single hair root or a microscopic blood stain left at a crime scene.Todays, PCR has found widespread and innumerable uses in forensics, genetics, DNA fingerprinting, bacteriology, virology, cloning and many other areas. Major research areas such as biomarker discovery, gene regulation and cancer research are challenging today’s PCR technologies with more demanding requirements. Reproducibility of data and time to results are still major problems encountered by...
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Posted by admin on Jul 31, 2014 in |
In the present review an attempt has been made to explore and study the various in vitro animal models used for the evaluation of hypolipidemic and antihyperlipidemic drugs. Hyperlipidemia has been ranked as one of the greatest risk factors contributing to the prevalence and severity of coronary heart disease. The main aim of treatment in patients with hyperlipidemia is to reduce the risk of the occurrence of cardiovascular or cerebrovascular disease. The present review throws a light on the various herbal drugs used as potential hypolipidemics and antihyperlipidemics. Emphasis has been laid on the study of animal models used in the evaluation and screening of antihyperlipidemic drugs. The review also encompasses the various treatments used for the management of...
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Posted by admin on Jul 31, 2014 in |
The present investigation carried out in six villages of Almora district of Kumaun Himalaya regarding mild and native ethno-medicinal plants which were used by locals in their own traditional health care system. This study reveals the status of ethno-medicinal plants and their importance preserved by locals of Kumaun region. During the study it was observed that 47 species of medicinal plants belonging to 38 genera and 28 families were being used in ethno medicine by locals with advice of Vaidhyas and experienced persons of the region since long time. The main purpose of this study was to document the indigenous knowledge of Vaidhyas and other experienced persons of the area regarding the use of ethno-medicinal plants, their conservation and imparting this knowledge with younger generation. Because, the indigenous knowledge of local flora are being eroded in younger generation, therefore the present study may help in fulfill this gap...
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Posted by admin on Jul 31, 2014 in |
Many water insoluble drugs present in class 2 and it is characterized by low solubility and high permeability. Solubility of drug can be enhancing by increasing of dissolution rate. Many solubilization techniques are available for increasing of solubility as well as permeability like micronization, coacervation, complexation, solid dispersion, and cosolvent. Poorly soluble and dissolution profile creates problem in pharmaceutical industry for development of dosage form. Solid dispersions are the most attractive method for improving of bioavailability of poorly water soluble drugs. Reduction of particle size leads to increase in wettability and porosity of drugs. Porosity and wettability improves the solubility and dissolution...
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Posted by admin on Jul 2, 2014 in |
In the recent years, scientific and technological advancements have been made in the research and development of novel drug delivery systems by overcoming physiological troubles such as short gastric residence times and unpredictable gastric emptying times. Gastric emptying of dosage form is extremely variable process and ability to prolong and control the emptying time. Gastric transit time is valuable asset for dosage forms, which reside in the stomach for a long period of time than conventional dosage form. Several approaches are currently utilized in the prolongation of the gastric residence times, including floating drug delivery systems, swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems and other delayed gastric emptying devices. The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. This review explains briefly about types of floating system, advantages, limitation, floating mechanism, factors affecting floating system, drug candidates suitable for floating, evaluation parameters and...
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