Posted by admin on Apr 30, 2015 in |
Various drugs are available these days, which may either require long term administration via multiple doses or may be susceptible to enzymes and first pass-metabolism or all the above. One way to administer such drugs is through the transdermal route. After a transdermal delivery system is designed, it is important to evaluate it for various essential parameters that help us determine how effective it is, i.e. its physiochemical parameters, which describe the physical and some of the chemical properties of the patch and it’s in-vitro parameters, which would mimic how the patch would behave on exposure to real time conditions On the body. This article briefly reviews the ideal characters for choosing this mode of drug delivery, its advantages and provides an in-depth analysis of the techniques used to physio-chemically evaluate the delivery system’s important parameters and also the conditions that help understand the systems behavior in a real time...
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Posted by admin on Mar 30, 2015 in |
Herbal medicines are precious and valuable gift of nature. Indian system of medicine viz. Ayurveda is much prevailing in our country, which comprises of various traditional medicines. The practice of medicinal herbs for treating the diseases is very well known from ancient time. Actiniopteris australis (Syn: A. radiata; A. Dichotoma), is a xerophytic species of the fern family Actiniopteridaceae , listed among endangered and fast disappearing plants, found to be little explored with regards to its medicinal uses, reproductive methods and chemical constituents. Major phytoconstituents reported in this plant are hentriacontane, hentriacontanol, β-sitosterol palmitate, β-sitosterol, β-sitosterol-D-glucoside and Quarcetin-3-rutinoside (rutin). This plant has been reported for various biological activities such as antifertility, styptic, anthelmitic, anti-tubercular etc. 50 % Ethanolic extract can be used to develop a safe male contraceptive pill . It is also used as dietary supplement in malnutrition. It has shown to remove heavy metals like Selenium and Arsenic from the rhizosphere by Phytoremediation...
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Posted by admin on Mar 30, 2015 in |
Since last decade, the interdisciplinary research of Nanoemulsions (NEs) have gained great attention in research and drug designing owing to their promising range of applications in the field of pharmaceutics, drug delivery through different route, cosmetics, to name a few. In addition to the small droplet size these non-equilibrium liquid systems have interesting properties including optical clarity, preparatory ease, thermodynamic stability, high bioavailability, resistant to creaming, flocculation, coalescence and sedimentation, low viscosity and increased surface area, among others. Due to these peculiar properties, NEs have become an authentic tool in the drug delivery system. This article pertains to the types of NEs, characterization techniques, different methods of preparation of stable NEs with special emphasis on the various routes by which drug formulated NEs can be administered. Recent advancements of the fascinating applications of NEs in the delivery of the usually hydrophobic drugs and other bio actives/biotechnology, pharmaceutical ingredients are...
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Posted by admin on Mar 30, 2015 in |
The gastroretentive drug delivery system has been utilized to obtain prolonged and uniform release of drug in stomach. Thus increase bioavailability and decrease the administration frequency. A peptic ulcer is a break in the lining of the stomach, esophagus or duodenum. Peptic ulcer may be due to H. Pylori bacteria, acid of the stomach cell or nonsteroidal anti-inflammatory drugs (NSAIDS). The gastroretentive drug delivery system may be single unit (floating tablet) or multiunit system (floating microspheres). The single unit floating system is more popular but has the disadvantage that its purpose would not be achieved if it fails to float or rapidly emptied from stomach. The multiunit floating system may be better because they reduce inter subject variability in absorption and also lower the probability of dose dumping. Thus, the purpose of preparing multiunit dosage form is to be developing suitable formulation and has all the advantage of a single unit dosage form and also devoid of disadvantage of single unit...
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Posted by admin on Mar 30, 2015 in |
Noni (Morinda citrifolia) is one of the important traditional medicinal plants have been used by Polynesia over a period of 2000 years. Morinda citrifolia belongs to family Rubiaceae (Coffee family) which is an evergreen small sized tree, with glossy and deeply veined leaves found in tropical regions and islands of South Pacific, West Indies, India, Africa, and Australia. Noni fruit juice traditionally has been used in different disorders such as abnormal menstruation, acne/ boils, constipation, diarrhea, arthritis, diabetes, fever, high blood pressure, gastric ulcers, sprains, mental depression, senility, poor digestion, atherosclerosis, blood vessel problems, and drug addiction. Noni consist of major chief chemical constituents such as alkaloid xeronine, scopoletin and dammacanthol, besides this it also contains Vitamin A and C and minerals like magnesium, potassium, iron, aminoacids, alizarin, ursolic acids. The review summarizes the pharmacological action and traditional uses of Noni along with the scientific researches and novel pathways to treat cancers and various neurological disorders. Noni can inhibit cancer via inhibition of ras a GTP binding protein and...
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