Posted by admin on Jan 30, 2015 in |
Diabetic nephropathy is a major complication of diabetes and the most common cause of end stage renal damage (E.S.R.D). Diabetic nephropathy is a leading cause of morbidity and mortality and its prevalence is continuously increasing in industrialized nations. Hyperglycemias, hyperlipidaemia and hypertension are considered to be the major risk factors implicated in the progression of nephropathy. Possible mediators of untoward effects of hyperglycemias include advanced placation end products (AGEs) known to accumulate in diabetic subjects. However, mechanisms underlying the pathogenesis of diabetic nephropathy are not completely understood. AGEs have been recently reported to play an important role in the pathogenesis of diabetic complications, particularly in the progression nephropathy. At present, no promising therapy is available to treat patients with diabetic nephroapthy due to lack of understanding of mechanism involved in the pathogenesis of nephropathy. There have been wide-ranging reports underline the involvement of AGEs in progression of the diabetic nephropathy, but the exact mechanism is not known clear yet, Therefore in these review are trying to explore the interactive...
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Posted by admin on Jan 30, 2015 in |
Nature is an eminent source of potential therapeutic drugs, however; most of the herbal bioactives are left unexploited as precise remedies due to lack of appropriate formulation design and development. Pharmacological interventions of herbal molecules may often be limited due to insufficient solubility, bioavailability as well as instability aspects and it remains one of the most challenging facet for pharmaceutical scientists worldwide. Solid dispersion is one of the well established and convenient techniques for improving the oral absorption of drugs with poor aqueous solubility and dissolution rate. The objective of present study is to enlighten the role of solid dispersion approach for enhancement of solubility and bioavailability profile of various natural moieties. The manuscript also aims to summarize the important features of solid dispersions, carriers utilized, classification, preparation methods and characterization parameters. Numerous and significant research findings in the vistas of phytoconstitutents based solid dispersions are also...
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Posted by admin on Jan 30, 2015 in |
The histamine H3 receptor is an G protein-coupled receptor that regulates neurotransmission in the central nervous system and plays a major role in cognitive and homeostatic functions. The third histamine receptor was discovered in 1983 by a traditional pharmacological approach, consisting of assessing the inhibitory effect of histamine on its own release from depolarized rat brain slices. Histamine H3 receptors are found mostly in central nervous system also to some extent in peripheral tissues and involved in the regulation of release of various neurotransmitters in brain. They have been implicated in diverse potential therapeutic applications such as sleep wake disorders, attention-deficient hyperactivity disorder, epilepsy, cognitive impairment and obesity. This review is aimed to provide an overview of marketed preparations and also experimental H3 receptor antagonists under pipeline of drug discovery and...
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Posted by admin on Dec 25, 2014 in |
Today, Proliferation is being observed in neutraceutical industry due to health seeking consumer trend.Neutraceutical has evolved from health promoting to disease preventing supplements. Various herbs and their phytochemicals discussed in the present review can prove potent neutraceuticals as they are pharmacologically safe and provide advantages in terms of suppressing tumor progression, increasing the sensitivity of chemo- and radio- therapeutics, and alleviate the side effects of chemo- and radio-therapy.The review has been devoted towards better understanding of potential of these nutraceuticals as combinational therapy in cancer...
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Posted by admin on Dec 25, 2014 in |
Since 1982, Wnt1 (Wingless int-1) was first identified in mammary carcinoma. Further, Wnt signaling pathway was discovered. Wnt signals were involved in stem cells development, regeneration, cell cycle and repair mechanism. Finally abnormality Wnt signals were stimulated variety of cancers. Especially, non-canonical signaling pathways such as Wnt/PCP and Wnt/Ca2+ pathway were involved in development process. These pathways regulated stem cells and organ development such as cell polarity, adhesion, cell shape and cell movement. Despite, aberrant expression of non-canonical pathway induced tumorigenesis in development. In clinical studies, drugs were developed against cancer cells not in cancer stem cells. Drugs will synthesis against cancer stem cells based on the activation of abnormality of Wnt...
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