Posted by admin on Jan 1, 2014 in |
The plethora of drug therapies and types of drugs demand different formulations, fabrications conditions and release kinetics. No single polymer can satisfy all the requirements. Therefore, there have been tremendous advances in area of biodegradable copolymers over the last 30 years. This article reviews current research on biodegradable polymers, focusing their potential as drug carries. The major classes of polymers are briefly discussed with regard to synthesis, properties and biodegradability, and known degradation modes and products are indicated based on studies reported in the literature. A vast majority of biodegradable polymers studied belongs to the polyester family, which includes polyglycolides and polylactides. Other degradable polymers such as polyorthoesters, polyanhydrides and polyphosphazenes are also discussed and their advantages and disadvantages are...
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Posted by admin on Jan 1, 2014 in |
The present work offers a review addressing the detailed chemistry and pharmacology of Peltophorum pterocarpum (belonging to Fabaceae family) regarded as one of the most significant plant species in traditional system of medicine. The plant is used in different parts of the world for the treatment of several ailments like stomatitis, insomnia, skin troubles, constipation, ringworm, insomnia, dysentery, muscular pains, sores, and skin disorders and is the source of a diverse kind of chemical constituents such as aliphatic alcohols, fatty acids, amino acids, terpenoids, phenolics, flavonoids, alkaloids, steroids etc. The isolated phytochemicals as well as different extracts exhibited numerous biological activities including antimicrobial, antioxidant, cytotoxic, aldose reductase inhibition and antiglycaemic activities. Hence, up to-date information on the chemical and pharmacological knowledge on this plant may be helpful to guide researchers anticipating to undertake further investigations in these directions. The present review covers literature up to middle of 2013 and enlists 42 references.The present work offers a review addressing the detailed chemistry and pharmacology of Peltophorum pterocarpum (belonging to Fabaceae...
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Posted by admin on Jan 1, 2014 in |
The objective of this review was to bring a chemicophysical approach towards dendrimers in different aspects including host-guest interaction and drug targeting. These nanosizedz polymeric molecules are unique in structural properties which have made dendrimers a potential candidate to lend itself as a carrier for drugs and bioactive molecules. Dendrimers offer the coupling of guest molecules by several phenomena including internal complexation and topological complexation forming catenanes and rotaxanes. Surface binding of guest molecules are achieved by coupling with the multiple surface binding groups. The physical attributes like size, shape, molecular weight and surface charge are modified for internalization of dendrimers into the specific cells by passive targeting mode. The polymer-drug couples are linked to targeting ligands for their active targeting by receptor mediated endocytosis. The binding and dissociation kinetics of such molecules can be tuned according to the desired retention time in a biological...
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Posted by admin on Dec 1, 2013 in |
Paederia foetida (Skunk vine) an indigenous plant belongs to family Rubiaceae. The plant is having a broad spectrum of use as in treatment of ailments like hepatic disorders, rheumatoid arthritis, constipation, diabetes, coughs, asthma, itches, wounds, stomachache, diarrhoea, dysentery, pain, typhoid, pneumonia, toothache, cancer, flatulency, body ache, and bone fractures etc. Literature data reveals the presence of asperuloside, paederosidic acid, phenolic compounds, alkaloid, volatile oil, sitosterols, stigmasterol, campesterol, ellagic acid, lignans, iridoids, methylinedioxy compound, tannins, triterpenoids, urosil acid, epifriedelinol and found to have anti-ulcer, anti-diarrhoeal, anti-hyperglycemic, antioxidant, antitussive, anthelmintic, hepatoprotective activity. This review target at gathering the research work undertaken till date on this plant in order to provide sufficient baseline information for future works and commercial...
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Posted by admin on Dec 1, 2013 in |
The World Health Organization adopted a major policy change in accepting that most developing nations would have to make use of more traditional medical practices for primary health care. Piper betel L.belongs to family Piperaceae commonly known as Pan. It is extensively grown in Sri Lanka, India, Thailand, Taiwan and other Southeast Asian countries. This oil may be used as an industrial raw material for manufacturing medicines, perfumes, mouth fresheners, tonics, food additives etc. The leaves are nutritive and contain anti carcinogens showing promise for manufacturing of a blood cancer drug. The present review aims to compile medicinal values of Piper betel generated through the research activity using modern scientific approaches and innovative scientific...
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