Posted by admin on Jun 1, 2014 in |
Cassia fistula Linn. (Family: Caesalpinaceae), commonly known ‘Sonali’ or ‘Bandarlati’, has been used in different traditional system of medicines for various ailments since ancient times. Cassia fistula grows throughout in Bangladesh and in many other Asian countries such as India, China, Hong Kong, Philippines, Malaysia, Indonesia, and Thailand. This article aims to provide a comprehensive review on the phytochemical and pharmacological aspects of Cassia fistula. In traditional medicine, it has been used in the treatment of diabetes, hematemesis, leucoderma, pruritis, intestinal disorder and as antipyretics, analgesic and laxative. The fruits, stem bark, and leaves of this plant contain a variety of biologically active compounds such as anthraquinones, flavonoids, flavon-3-ol derivatives, alkaloid, glycosides, tannin, saponin, terpenoids, reducing sugar and steroids those have various medicinal properties. The fruit and stem bark extract shows various activities like antipyretic, anti-inflammatory, antioxidant, antidiabetic, hypolipidemic, hepato-protective, antimicrobial, antitumor, antiulcer etc. The article reviews the various activities of the...
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Posted by admin on Jun 1, 2014 in |
An ideal wound Dressing need to be redefined based on the nature of wound and wound classifications. Since generations, wound have been defined as self-healing process, but chronic wounds and other wound requires handling and care from different parameters like moist conditions, biocompatibility, microbial infection to mention a few. Traditional methods have been continuously worked upon to deliver better products. Starting from simple gauze dressings in 1900’s to bioactive dressings till today have been worked upon. Bioactive dressings based on different materials sodium alginate, chitosan, hydrocolloid, iodine has been covered in this review. Based on wounds different classifications of type of wounds, correlation of wounds with wound dressing have also been focussed upon. This has led to development of interactive dressings which are further developed as per wound requirement viz. semipermeable and hydrogel dressings. Efforts are in process to develop superabsorbing and bioactive material for critical wound care. The conventional primary and secondary dressings have been replaced by composite dressings composed by 4 to 5 layers with super absorbing...
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Posted by admin on May 1, 2014 in |
This overview firstly highlights biology of endophytic microbes from medicinal plants as well as their chemistry with emphasis on the important merging of microbiology and natural products chemistry and its role in improving our current knowledge of endophytic associations in medicinal plants. Secondary metabolites of medicinal plants-derived endophytes reported in recent years are grouped according to their bioactive properties including antitumor, antimicrobial, growth-promoting, antioxidant, antithrombotic, insecticide and other functions. New insights on distributing characteristics and biodiversity of these endophytes including bacteria, actinomycetes and fungi are also presented. It suggested that endophytic microbe from medicinal plant is a treasure trove of bioactive natural products with a good and potential application prospect in pharmacy and...
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Posted by admin on May 1, 2014 in |
In the treatment of health related dysfunctions, it is desirable that the drug reaches its site of action at a particular concentration and that this therapeutic dose range remains constant over a sufficiently long period of time to alter the process. Delivery of hydrophobic molecules and proteins has been an issue to poor bioavailability following administration. Thus, micelle carrier systems are being investigated to improve drug solubility and stability. Due to problems with toxicity and immunogenicity, biodegradable polymers are being explored as substitutes for synthetic polymers in the development of new micelle system. By grafting hydrophobic moieties to the biodegradable polymer backbone, self-assembled micelles can be readily formed in aqueous solution. The mechanisms involved in controlled release require polymers with a variety of physicochemical properties. Thus several polymers have been tested as potential drug delivery systems, including nano- and micro-particles, dendrimers, nano- and micro- spheres, capsosomes and micelles. In all these systems, drugs can be encapsulated or conjugated in polymer matrices. This review will provide an overview of the...
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Posted by admin on May 1, 2014 in |
In comparison among the other groups of semisolid preparations, the use of gels has been emerged both in cosmetics and in pharmaceutical preparations because of its unique array of features. Despite of providing several benefits the category gel faces limitations in delivering hydrophobic drug molecules via skin. So in order to cover up this lacking a recent emulsion based approach is being used so that even a hydrophobic therapeutic moiety can enjoy the unique properties of gels. The use of gels and emulsions as combined dosage form results into formation of emulgel showing dual release. With this approach the use of polymers with enhanced effect in release pattern has been emerged providing sustained and controlled release. The presence of a gelling agent in the water phase converts a classical emulsion into an emulgel. These emulgels show major advantages on novel vesicular system as well as on conventional systems in various aspects. Emulgels have several favourable properties for dermatological use such as being thixotropic, greaseless, easily spreadable, easily removable, emollient, nonstaining, long shelf life, bio-friendly, transparent and...
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