Posted by admin on Mar 1, 2014 in |
Free radicals play an effective role in the pathogenesis of different pathological diseases together with cancer. Potential biological targets for free radical attack comprise lipids, proteins and nucleic acids. Free radical induced lipid peroxidation causes a loss of cell homeostasis by modifying the structure and functions of cell membrane. The most important characteristic of lipid peroxidation is to cause a substantial DNA- MDA (Malondialdehyde) adducts by interacting with cellular DNA. Enzymatic antioxidants Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx) and non-enzymatic antioxidants vitamin E, Reduced glutathione (GSH) proceed synergistically with one another to detoxify the effects of lipid peroxidation. There is occurrence and contribution of oxidative stress in different types of cancer including, Ovarian cancer, Breast cancer, Oral cancer, Lung cancer, Leukemia, Cervical cancer, Prostate cancer, Gastric and Colon cancer which increase the pathogenesis and cause tissue damage in cancer. Lipid peroxidation and levels of enzymatic and non-enzymatic antioxidants can be used as markers of oxidative stress in various...
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Posted by admin on Mar 1, 2014 in |
Microbial fibrinolytic proteases are of considerable interest in view of their specific activity and stability at biological pH. This review describes different isolation methods which enable the screening and selection of promising organisms for industrial production. Further, strain improvement using mutagenesis and/or recombinant DNA technology can be applied to augment the efficiency of the producer strain to a commercial status. The various nutritional and environmental parameters affecting the production of fibrinolytic proteases are delineated. The purification and properties of these fibrinolytic proteases is discussed, and the use of fibrinolytic proteases is...
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Posted by admin on Mar 1, 2014 in |
Nanoparticles have advantages, such as small size, high surface area, and modification using functional groups for high capacity or selectivity. Nanoparticles with Proteins are especially worthy of notice because they can be used for site specific targeting. Particulate systems like nanoparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmaco-dynamic properties of various types of drug molecules. They have been used in vivo to protect the drug entity in the systemic circulation, restrict access of the drug to the chosen sites and to deliver the drug at a controlled and sustained rate to the site of action. Nowadays active research is focused on the preparation ofnanoparticles using proteins like albumin, gelatin, gliadin and legumin.Protein nanoparticles hold promise as drug delivery systems for parentral as well as oral. This article reviews the introduction of nanoparticles with especial focus on protein nanoparticles with preparation, characterization and applications of Protein...
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Posted by admin on Mar 1, 2014 in |
Hepatic diseases (Liver diseases) are a major worldwide health problem, with high endemicity in developing countries. Hepatic disease is a term for a collection of conditions, diseases, and infections that affect the cells, tissues structures, or functions of the liver. Liver has a wide range of functions, including detoxification, protein synthesis, and production of biochemical necessary for digestion and synthesis as well as breakdown of small and complex molecules, many of which are necessary for normal vital functions. There are no specific allopathic medicines used as hepatoprotective, although different research works are going on some drug. Herbal drugs are more widely used than allopathic drugs as hepatoprotectives because they are inexpensive, have better cultural acceptability, better compatibility with the human body and minimal side effects. The present review discusses different types of recently herbal plants containing hepatoprotective...
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Posted by admin on Mar 1, 2014 in |
Asparagus racemosus, a climbing Ayurvedic plant, is known for its numerous activities such as hyperlipidemia, hypertension, angina, dysmenorrhea, anxiety disorders, benign prostatic hyperplasia (BPH), leucorrhoea and urinary tract infections. This plant possesses a wide range of secondary metabolites inclusive of steroids, alkaloids, dihydrophenanthrene derivatives, flavonoids, furan derivatives and essential oils. Information from the literature suggests that, the major constituents of A. racemosus are steroidal saponins which are mainly responsible for different biological activities of A. racemosus. The review summarizes the information concerning the cultivation, morphology, phytochemistry, biological activities, safety profile, marketing status and conservation techniques of A....
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