Posted by admin on Oct 1, 2013 in |
Arthritis is still a challenge for medical research. Pharmaceutical research has resulted in several new approaches for treatment/management of arthritis including drugs like the biologic disease modifying anti-rheumatic drugs (DMARDs). Several disadvantages like serious side effects, high costs and requirement of parenteral administration still invite more research in this area to provide a convenient, affordable therapy with lesser or no side effects. Traditionally used herbal medicines, due to their anti-inflammatory and immunomodulatory properties, have potential to be a therapy of choice for arthritis patients and are now extensively being studied. Although a number of these medicines are being used traditionally for their therapeutic activity, development of their novel drug delivery systems was not attractive to the scientists due to insufficient knowledge about their exact mechanism of action and difficulties in processing, standardising, extracting and identification of active constituents. Current research demonstrates that the effectiveness and bioavailability of herbal actives can be improved by understanding of exact mechanism of action and by formulating them into novel technologies like liposomes, phytosomes...
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Posted by admin on Oct 1, 2013 in |
Cancer is a substantial world health threat, & a largest cause of death in peoples of various age groups and economic backgrounds. This dramatic increase in the global burden of cancer has spurred research and many pharmacological studies as an attempt to limit the progression of this disease. Painful, expensive chemotherapy by dietary supplements have come forth as a novel significant approach in ailment of cancer. Since ancient times mushrooms has been used a good resource of dietary supplement. Mushroom is attributed by many medicinal properties, due to presence of phytochemicals, antioxidant, anticancer, antiviral, antimicrobial, anti-diabetic, anti-inflammatory etc. bioactive compounds in fruiting bodies and cultured mycelium. Polysaccharides and antioxidant have been extensively studied biologically active compounds of mushroom for their cytotoxic as well as immunomodulation properties. In this review we will highlight the recent findings on anticancereous bioactive compounds of mushroom, their therapeutic potentials and mode of action and the need for further investigation in cancer...
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Posted by admin on Oct 1, 2013 in |
Since ancient times, herbal drugs are used in traditional system of medicine such as Siddha, Ayurvedaand Unani. The allopathic system of medicine adopted many medicinal plants to derive newer molecules for challenging diseases. The plant Indigofera aspalathoides which is well known as ‘Sivanar vembu’ is widely used for skin diseases. Phytochemical and Pharmacological researchers have screened it for its anti-cancerous and antioxidant property. This review focuses all updated information about its authentication, phytochemistry and pharmacology. The phytochemical evaluation of the plant showed phenolic compounds, tannin, alkaloides, triterpenes, flavones, saponin and steroids. This drug is widely screened for its anti-cancerous and anti-oxidant activity. Anti-microbial, hypoglycemic, hepatoprotective, anti-inflammatory and antiviral activity were also reported. A thailam (oil prepared by traditional extraction procedure) prepared from this plant is widely used by the Siddha practioners for various ailments. This review focuses the lot of medicinal properties of the plant through the scientific validation and strongly supports the traditional...
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Posted by admin on Oct 1, 2013 in |
Here, we review the development of prospective image processing systems in molecular diagnostics and of pharmacologically active ingredients for patient-specific therapeutic approaches. These projects require not only high demands on quality, safety, and specificity but also, rapid, efficient and irreversible ligation routes during the synthesis of future pharmaceuticals. The Diels-Alder ligation reaction with inverse electron demand (DARinv) is an eligible technology not restricted to medical applications, but valuable in selective modification by functionalization of polymers, organic and inorganic surfaces and micro arrays. Additionally, the DARinv technology is considered as an attractive strategy-platform for efficient syntheses of promising pharmacologically active components and derivatives of natural molecules with an optimized therapeutic index. We like to encourage scientists working with the brilliant concept of Sharpless’s “Click chemistry”, to intensify their research with this valuable DARinv technology able to open the door for regioselective, stereospecific, and bioorthogonal exigent syntheses of substances of highest quality inconceivable so...
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Posted by admin on Sep 1, 2013 in |
Herbal medicines are represented as the most potential field of alternative medicines all over the world for a number of diseases in which allopathic medicines have no or little solution. For this reason, a large proportion of the Indian population for their physical and psychological health depends largely on traditional system of medicines. Doxorubicin is an anticancer drug used in the treatment of cancer such as breast cancer is no longer use or high dose of doxorubicin causes cardiomyopathy which is rational side effect of this drug. Several attempts have seen made to control this problem, in which herbal medicines have shown some encouraging results and touted as an important adjuvant therapy. Through this paper the recent development of herbal solution to control doxorubicin induced cardiomyopathy is presented along with their future...
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