Posted by admin on Mar 1, 2014 in |
Exploration of biological diversity for identification of novel bioactive molecules or therapeutically more potential than the marketed products is a continuous ongoing process for drug development research. Indian traditional therapies have been a part of our lifestyle since ages. Due to their knowing ability and applications, this knowledge has long been used as thriving sources for discovery of new drug molecules. Historical text or traditional knowledge including folklore, ethnobotany or ethnopharmacological studies are proving to be a powerful tool for searching lead molecules for the development of new drugs. This review article presents the contribution on 33 medicinal plants along with their traditional uses, bioactive constituents, biological activities, chemical structures, and 30 marketed drug formulations at national and international markets. A brief note on the recent discovery on osteogenic compounds from Ulmus wallichiana, folk traditional plant used for healing fractured bones in Uttarakhand Himalaya is also discussed in this...
Read More
Posted by admin on Mar 1, 2014 in |
Diabetes is a growing health concern worldwide and now emerging as an epidemic world over. The management of diabetes is still a major challenge. Plants have always been a source of drugs for humans since time immemorial. The Indian traditional system of medicine is replete with the use of plants for the management of diabetic conditions. According to the World Health Organization (WHO), up to 90% of population in developing countries use plants and its products as traditional medicine for primary health care. There are about 800 plants which have been reported to show anti-diabetic potential. Thus there is great demand for research on natural products with anti-diabetic properties. Numerous studies have confirmed the benefits of medicinal plants with anti-hyper-glycaemic effects in the management of diabetes mellitus. The present paper is an attempt to list of the plants with anti-diabetic and related beneficial effects originating from different parts of world. History showed that medicinal plants have been used in traditional healing around the world for a long time to...
Read More
Posted by admin on Mar 1, 2014 in |
Human papillomavirus is one of the most common causes of sexually transmitted disease in both men and women worldwide. Genital HPV types are divided into high and low-risk types, on the basis of oncogenic gene potential. Molecular & epidemiologic studies have confirmed the interaction between high risk HPV types (especially HPV-16 & 18) and cervical squamous cell low risk strain. In high grade Intra epithelial neoplasias & invasive cancers, generally integration of HPV-DNA into the host genome disrupts or deletes the E2 region, which results in loss of its expression. The E6 and E7 gene deregulate the host cell growth cycle by binding and inactivating two tumor suppressor proteins: the tumor suppressor protein (p53) and retinoblastoma gene (pRb). The HPV E6 gene binds to p53 and targets it for rapid degradation leads to an increased expression of E6 and E7 genes. The inactivations of p53 & pRb proteins can increased proliferation rate & genomic instability. In addition, the potential of activated oncogenes cause chromosome instability may transformed in the...
Read More
Posted by admin on Feb 1, 2014 in |
The people in India have an outstanding knowledge of medicinal plants acquired over centuries.A passion for studying medicinal plants is evident both in folk and scholarly traditions. The indigenous mode of understanding and using plants is different from the modern scientific way. It includes botanical, medical and astrological elements. This is the basis of green pharmacy. Indians obviously care for medicinal plants because they know so many of them, so much about them and have worked extensively on their application. It is a remarkable fact that the use of medicinal plants is still a living tradition in the form of a million village-based folk carriers. These traditional birth attendants, bonesetters, herbal healers and wandering monks are invisible to policy makers and therefore not taken into account as a public health resource. Apart from these specialised folk healers there are also millions of women and elders with traditional knowledge of food and nutrition and herbal home-remedies. However, the revitalisation of this vast and diverse folk tradition does not appear on...
Read More
Posted by admin on Feb 1, 2014 in |
The emergence of RNAi, has found new horizons in siRNA as drug molecule. This technology offers a great promise in the achieving efficient treatment. There is a demand for designing efficient siRNA delivery systems/ vehicles that can achieve targeted delivery and replicate the invitro success. The siRNA delivery system selection is based on target cell type. The siRNA delivery systems are categorized as viral and non-viral delivery systems. Non-viral delivery system includes liposomes; polymers; peptides etc. are the widely studied delivery systems for siRNA. Non-viral delivery systems have advantages of control over functionality and industrial scalability. Liposomes were one of the first studied siRNA non-viral delivery systems which with time have evolved on account of modifications on certain attributes like surface charge, surface tagging, composition etc. Peptides and Polymers are the recent addition to the non-viral siRNA delivery vehicles on account of biocompatibility factor. This review clubs the non-viral siRNA delivery systems which have attracted research and have shown efficiency in the clinical...
Read More
