Posted by admin on Jan 1, 2014 in |
Early introduction of complementary foods (weaning) before 4 to 6 months of age and unmodified cow’s milk before age 12 months are associated with several health risks in children. Too early introduction of unmodified cow’s milk and milk products to infants and toddlers has adverse effects on their iron stores. Children can develop iron-deficiency anemia from chronic enteric blood loss even when occult blood is not found in stools on random testing. Several mechanisms have been identified that may contribute to iron deficiency anemia in young population group. The most important of these is probably the low iron content of Cow’s Milk. Other risks in association to the consumption of unmodified cow’s milk in infants include increased renal solute load; increased blood loss from the gastrointestinal tract, chronic constipation, and anal fissures; and an increased risk for subsequent type 1 and type 2 diabetes. Evidence is now also growing to show that iron deficiency anemia is associated with developmental delay, and that the association is causal. Breastfed infants may...
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Posted by admin on Jan 1, 2014 in |
Cancer is a complex disease occurring as a result of a progressive accumulation of genetic aberrations and epigenetic changes that enable escape from normal cellular and environmental control. Cancer is treated with surgery, radiation, chemotherapy, hormones and immuno-therapy. But, due to side effects such as toxicity, death of normal cells near to cancer cells, second formation of cancers; these treatment was not successful. Targeted gene therapy is the most acceptable for cancer treatments because the above shortcomings overcome by it. Targeted therapy refers to a new generation of anticancer drugs that are designed to interfere with a specific molecular target, usually a protein with a critical role in tumor growth or progression. This approach differs from the more empirical approach used in conventional cytotoxic chemotherapy, which has remained the mainstay of anticancer drug use over the past several decades. Targeted therapy has the potential to reduce or eliminate many of the present problems in the field of cytotoxic chemotherapy, such as the production of serious host-cell toxicity. Several types...
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Posted by admin on Jan 1, 2014 in |
Indian literatures like Ayurveda and various ancient literatures have stated herbal remedies for a number of human ailments. Annona reticulata which is commonly known as bullock’s-heart in English and Ramphal in Hindi and Marathi is having various pharmacological activities such as antioxidant, anticancer, analgesic and CNS depressant, antimalarial, anthelmintic, in syphilis and few more. Some compounds have been isolated and reported from the extract of various parts of the plant possessing good pharmacological activity. The studies performed on the seed and root extract also evidenced that the same compounds causes cell death in various cancer cell lines. This review article is a sincere effort to put forward the medicinal importance and botanical, phytochemical, pharmacological details of the...
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Posted by admin on Jan 1, 2014 in |
The plethora of drug therapies and types of drugs demand different formulations, fabrications conditions and release kinetics. No single polymer can satisfy all the requirements. Therefore, there have been tremendous advances in area of biodegradable copolymers over the last 30 years. This article reviews current research on biodegradable polymers, focusing their potential as drug carries. The major classes of polymers are briefly discussed with regard to synthesis, properties and biodegradability, and known degradation modes and products are indicated based on studies reported in the literature. A vast majority of biodegradable polymers studied belongs to the polyester family, which includes polyglycolides and polylactides. Other degradable polymers such as polyorthoesters, polyanhydrides and polyphosphazenes are also discussed and their advantages and disadvantages are...
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Posted by admin on Jan 1, 2014 in |
The present work offers a review addressing the detailed chemistry and pharmacology of Peltophorum pterocarpum (belonging to Fabaceae family) regarded as one of the most significant plant species in traditional system of medicine. The plant is used in different parts of the world for the treatment of several ailments like stomatitis, insomnia, skin troubles, constipation, ringworm, insomnia, dysentery, muscular pains, sores, and skin disorders and is the source of a diverse kind of chemical constituents such as aliphatic alcohols, fatty acids, amino acids, terpenoids, phenolics, flavonoids, alkaloids, steroids etc. The isolated phytochemicals as well as different extracts exhibited numerous biological activities including antimicrobial, antioxidant, cytotoxic, aldose reductase inhibition and antiglycaemic activities. Hence, up to-date information on the chemical and pharmacological knowledge on this plant may be helpful to guide researchers anticipating to undertake further investigations in these directions. The present review covers literature up to middle of 2013 and enlists 42 references.The present work offers a review addressing the detailed chemistry and pharmacology of Peltophorum pterocarpum (belonging to Fabaceae...
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