Posted by admin on Jan 1, 2014 in |
The objective of this review was to bring a chemicophysical approach towards dendrimers in different aspects including host-guest interaction and drug targeting. These nanosizedz polymeric molecules are unique in structural properties which have made dendrimers a potential candidate to lend itself as a carrier for drugs and bioactive molecules. Dendrimers offer the coupling of guest molecules by several phenomena including internal complexation and topological complexation forming catenanes and rotaxanes. Surface binding of guest molecules are achieved by coupling with the multiple surface binding groups. The physical attributes like size, shape, molecular weight and surface charge are modified for internalization of dendrimers into the specific cells by passive targeting mode. The polymer-drug couples are linked to targeting ligands for their active targeting by receptor mediated endocytosis. The binding and dissociation kinetics of such molecules can be tuned according to the desired retention time in a biological...
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Posted by admin on Dec 1, 2013 in |
Paederia foetida (Skunk vine) an indigenous plant belongs to family Rubiaceae. The plant is having a broad spectrum of use as in treatment of ailments like hepatic disorders, rheumatoid arthritis, constipation, diabetes, coughs, asthma, itches, wounds, stomachache, diarrhoea, dysentery, pain, typhoid, pneumonia, toothache, cancer, flatulency, body ache, and bone fractures etc. Literature data reveals the presence of asperuloside, paederosidic acid, phenolic compounds, alkaloid, volatile oil, sitosterols, stigmasterol, campesterol, ellagic acid, lignans, iridoids, methylinedioxy compound, tannins, triterpenoids, urosil acid, epifriedelinol and found to have anti-ulcer, anti-diarrhoeal, anti-hyperglycemic, antioxidant, antitussive, anthelmintic, hepatoprotective activity. This review target at gathering the research work undertaken till date on this plant in order to provide sufficient baseline information for future works and commercial...
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Posted by admin on Dec 1, 2013 in |
The World Health Organization adopted a major policy change in accepting that most developing nations would have to make use of more traditional medical practices for primary health care. Piper betel L.belongs to family Piperaceae commonly known as Pan. It is extensively grown in Sri Lanka, India, Thailand, Taiwan and other Southeast Asian countries. This oil may be used as an industrial raw material for manufacturing medicines, perfumes, mouth fresheners, tonics, food additives etc. The leaves are nutritive and contain anti carcinogens showing promise for manufacturing of a blood cancer drug. The present review aims to compile medicinal values of Piper betel generated through the research activity using modern scientific approaches and innovative scientific...
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Posted by admin on Dec 1, 2013 in |
The peanut or groundnut (Arachis hypogaea) is a species in the legume family (Fabaceae). There are different varieties like Virgina group, Spanish group, Runner group, Valencia group, Tennessee red and Tennessee white. Peanut consists of 30 essential nutrients and phytonutrients. Peanuts are a good source of vitamins & metals. Peanut hulls consist of crude fiber, cellulose, water, crude protein, ash and fat. Chemical constituents present in the plant are acids, arachin, lecithin protein, flavonoids, beta-carotene, amino acids, minerals, fat, carbohydrates etc. It has varies pharmacological activities like antimicrobial, antifungal, antiviral, antioxidant, anticancer, antihypertensive, neuroprotective, antimutagenic, antiproliferative, anti-inflammatory. Peanuts can help to enrich the soil. Peanuts are legumes and are able to fix nitrogen in their roots. Peanut oil used as a liniments, plasters, soap & lubricant. Roots are used alternative fuel & cosmetic purpose. Peanut allergy is the most common cause of deaths from food...
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Posted by admin on Dec 1, 2013 in |
Solubility of orally administered drug is major challenge of pharmaceutical industry as nearly 35-40% of newly launched drugs possess low aqueous solubility which leads to their poor dissolution and low bioavailability, resulting in high intra & inter subject variability & lack of dose proportionality. This can be increased by different methods like salt formation, solid dispersion and complex formation. Self-Emulsifying Drug Delivery System (SEDDS) is gaining popularity for improving the solubility of lipophilic drugs. SEDDS are defined as isotropic mixtures of one or more hydrophilic solvents and co-solvents/surfactants that have a unique ability of forming fine oil-in-water (o/w) micro emulsions upon mild agitation followed by dilution in aqueous media, such as GI fluids.Present review provides an updated account of advancements in SEDDS with regard to its composition, evaluation, different dosage forms and newer techniques to convert liquid SEDDS to solid and also various...
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