Posted by admin on Oct 1, 2013 in |
Introduction: Melatonin is a neuro-hormone secreted from the pineal gland and involved in various regulatory activities in body. Ever-increasing use of melatonin supplements and enlarging research evidences make the authors undertook the review to arrive at a qualitative conclusion whether melatonin supplements can act as potential treatment options or not. Methodology: A comprehensive search was undertaken in different electronic databases using various search terms. A total of 225 studies were identified including clinical research studies and basic experiments. Data were extracted individually from the studies and compiled in the end. Results: Melatonin has been used successfully in chronic insomnia and as an anti-oxidant in cancer and other age-related neuro-degenerative disorders, especially Alzheimer’s disease and Autistic disorders. Its evidences of use in other conditions remained insufficient and inconclusive. Conclusion: Melatonin therapy may be considered as efficacious and safe in insomnia and as an anti-oxidant; however, other roles needs to be evaluated in further...
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Posted by admin on Oct 1, 2013 in |
Embelia ribes Burm F. is large scandent shrub, disturbed throughout India and belongs to the family Myrsinacae. It is commonly known as false black pepper or Vidanga. E. ribes grows in semi-evergreen and deciduous forests at an altitude of 1,500m found in central and lower Himalayas, Arunachal Pradesh, Assam, Bengal, Orissa, Andhra Pradesh and Madhya Pradesh throughout India. Embelia ribes has been proven to have great pharmacological potential with a great utility and usage as folklore medicine. The root, berries and leaves of Embelia ribes is used in herbal formulas. It is used as antibacterial, antifertility activities, antiprotozoal, abdominal disorders, lung diseases, constipation, indigestion, fungus infections, mouth ulcer, sore throat, pneumonia, heart disease and obesity, analgesic, anti-inflammatory, antioxidant and formulations of Embelia ribes are Ardrakakhandavaleha, Eranda paka, Krimighna kashaya churna, Vidangadi churna, Taramandura guda, Guduchi lauha, Abhayarishta, Kumari asava, Manibhadra yoga, Pippalyasava, Kaishore guggulu, Vyoshadi guggulu, Saptavishantika guggulu, Eladi ghrita, Kasisadi ghrita, Chandraprabha vati, Wdangadi lauha, Vidanga...
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Posted by admin on Oct 1, 2013 in |
Pelletization can be defined as an agglomeration process that converts fine powders or particles of a bulk drug and excipients into small, free-flowing, more or less spherical units, called pellets. The size of the pellets is 0.5-2mm. Pellets have the free flowing capacity and have low porosity about 10%. Preparation methods include direct pelletizing,powder layering,Suspension or Solution layering, pelletization by extrusion and spheronization, spherical agglomeration, compression/balling,Cryo pelletization,melt spheronization, globulation or droplet formation, fluid bed coating. Pellets have various advantages when compare to normal conventional dosage forms, like they help in giving accurate dosage to the paediatrics and geriatrics and even to the bed ridden persons,reduces peak plasma fluctuation, Minimize potential side effects without lowering bioavailability, avoiding high local concentration, Less susceptible dose dumping. At present usage of pellets has increased largely due to their advantages and there novel approaches, the novel approaches of pellets includes; 1). They help in preparation of modified release multiple dosage form with different release patterns like immediate and sustained release pattern, 2) They help...
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Posted by admin on Oct 1, 2013 in |
Arthritis is still a challenge for medical research. Pharmaceutical research has resulted in several new approaches for treatment/management of arthritis including drugs like the biologic disease modifying anti-rheumatic drugs (DMARDs). Several disadvantages like serious side effects, high costs and requirement of parenteral administration still invite more research in this area to provide a convenient, affordable therapy with lesser or no side effects. Traditionally used herbal medicines, due to their anti-inflammatory and immunomodulatory properties, have potential to be a therapy of choice for arthritis patients and are now extensively being studied. Although a number of these medicines are being used traditionally for their therapeutic activity, development of their novel drug delivery systems was not attractive to the scientists due to insufficient knowledge about their exact mechanism of action and difficulties in processing, standardising, extracting and identification of active constituents. Current research demonstrates that the effectiveness and bioavailability of herbal actives can be improved by understanding of exact mechanism of action and by formulating them into novel technologies like liposomes, phytosomes...
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Posted by admin on Oct 1, 2013 in |
Cancer is a substantial world health threat, & a largest cause of death in peoples of various age groups and economic backgrounds. This dramatic increase in the global burden of cancer has spurred research and many pharmacological studies as an attempt to limit the progression of this disease. Painful, expensive chemotherapy by dietary supplements have come forth as a novel significant approach in ailment of cancer. Since ancient times mushrooms has been used a good resource of dietary supplement. Mushroom is attributed by many medicinal properties, due to presence of phytochemicals, antioxidant, anticancer, antiviral, antimicrobial, anti-diabetic, anti-inflammatory etc. bioactive compounds in fruiting bodies and cultured mycelium. Polysaccharides and antioxidant have been extensively studied biologically active compounds of mushroom for their cytotoxic as well as immunomodulation properties. In this review we will highlight the recent findings on anticancereous bioactive compounds of mushroom, their therapeutic potentials and mode of action and the need for further investigation in cancer...
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