Posted by admin on Jun 1, 2013 in |
The use of traditional medicines of natural origin is being encouraged for the treatment of chronic disorders, as synthetic drugs in such cases may cause unpredictable adverse effects. The various strategies which have been identified to defeat drug resistance, the investigation of new and effective natural products exhibiting antimicrobial activity against pathogenic microorganisms is likely to play a significant role to overcome drug resistance. The numbers of global infections produced by bacterial strains that are resistant to single and multiple antimicrobial drugs are on the rise. With emerging trends in nanotechnology it has become possible to address the problems associated with potential natural products to be developed as antimicrobial drug. Nanomaterials can improve the pharmacokinetics, bioavailability, therapeutic index and specificity of plant origin drugs. By smartly designing nanoscale carriers, therapeutic value of natural products can be drastically improved, number of plant origin drugs can enter into clinical trials and antimicrobial resistance can be cured. Nanosizing led to increase solubility of components, reduction in the dose via improved absorption of...
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Posted by admin on Jun 1, 2013 in |
Cancer spreads by metastasis which is the ability of cancer cells to penetrate into lymphatic and blood vessels, circulate through the bloodstream, and then invade and grow in normal tissues elsewhere. It is this ability to spread to other tissues and organs that makes cancer a potentially life-threatening disease. Cancer researchers involve in the study of the conditions necessary for cancer metastasis have discovered that, the most critical event required is the growth of a new network of blood vessels. This process of forming new blood vessels is termed angiogenesis. Many angiogenic inhibitors have been identified and used for therapeutic purposes but have not proved very beneficial in terms of long-term survival. This could be due to the non-specific nature of these inhibitors which accounts for their high toxic levels. We believe the way forward is to identify angiogenic inhibitors which are specific to vascular endothelial growth factor (VEGF) or their receptors (VEGFR-1, VEGFR-2, VEGFR-3). These target specific inhibitors of angiogenesis which come with minimum toxic levels could be...
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Posted by admin on May 1, 2013 in |
Postpolio syndrome (PPS) may affect survivors of paralytic poliomyelitis and is characterised by a complex of neuromuscular symptoms leading to a decline in physical functioning. The effectiveness of pharmacological treatment and rehabilitation management in PPS is not yet established. To review systematically the effects of any treatment for PPS compared to placebo, usual care or no treatment. Postpolio syndrome is characterized by the exacerbation of existing or new health problems, most often muscle weakness and fatigability, general fatigue, and pain, after a period of stability subsequent to acute polio infection. Diagnosis is based on the presence of a lower motor neuron disorder that is supported by neurophysiological findings, with exclusion of other disorders as causes of the new symptoms. The muscle-related effects of postpolio syndrome are possibly associated with an ongoing process of denervation and reinnervation, reaching a point at which denervation is no longer compensated for by reinnervation. The cause of this denervation is unknown, but an inflammatory process is possible. Rehabilitation in patients with postpolio syndrome should...
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Posted by admin on May 1, 2013 in |
Escalating social evil and global problem for pharmaceutical scientist world-wide is counterfeiting of drugs. Fraudulent representation of medication with an intention to deceptively represent its origin, authenticity and effectiveness is a counterfeited faked drug which is a potential massacre. The prominent role of drug is patient life-saving, but a drug being counterfeit encounters additive danger to patient. Global scenario indicates India accounts for one third of counterfeit drugs world-wide, being existence since 1982. It is spreading its roots in top most selling drugs like steroids, anticancer etc. This review provides an insight into the planning of counterfeit-free world by implementation of WHO guidelines, updating training programs for pharmacist, adapting innovating methods. The counterfeiters use sophisticated technology for huge profit and less trade risking for counterfeiting of drugs. This difficult task can be overcome by different diagnostic patterns like digital imaging, radio frequency identification (RFID), holographic labels, infra-red inks, supply chain tracking, chemical fingerprints. Inspite of increasing globalization and cross border trading, pharmacists play a major role in curbing the...
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Posted by admin on May 1, 2013 in |
Appropriate technology transfer is both integral and critical to drug discovery and development for new medicinal products and is also important to upgrade drug quality designed during research and development and to final product during manufacturing as well as to assure stable quality transferred. Successful development and commercialization of innovative technologies is always fraught with difficulties, multifaceted endeavour, and a variety of development tools exist to promote this activity, by far the most popular approach to directly promoting successful innovation is through technology transfer. To successfully and simultaneously develop appropriate clinical good manufacturing practice facilities, specify and design specialized process equipment, finalize process details, and correctly determine scale-up parameters requires the integrated efforts of a highly skilled technology transfer team. Successful technology transfer requires carefully studying numerous situations like careful evaluation of ultimate manufacturing requirements early in research and development and the consequent development of robust processes that withstand large-scale operation, the assembly of a detailed technology transfer document that provides manufacturing with both “know how” and “know why,”...
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