Posted by admin on May 1, 2013 in |
The current scenario was to study Polyelectrolyte complex. Polyelectrolyte complexes (PECs) represent a special class of polymeric compounds consisting of oppositely charged polyions that can have either cationic or anionic charges. Due to their charges they are hydrophilic, and normally water soluble, and can be used in a variety of applications, such as drug delivery, coatings, shampoos, or as flocculating agents in water treatment. These complexes avoid the use of chemical cross linking agent thereby to reducing the risk of toxicity. These complex formed is generally applied in different dosage form. A number of different, polymers are used to form polyelectrolyte complex. The present review emphasizes on the detail study on polyelectrolyte complex with their utility in drug...
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Posted by admin on May 1, 2013 in |
Attention deficit hyperactivity disorder (ADHD) is a developmental disorder. It is a chronic condition that affects millions of children and often persists into adulthood. ADHD is the most commonly studied and diagnosed psychiatric disorder in children. ADHD includes some combination of problems, such as difficulty sustaining attention, hyperactivity and impulsive behavior. Children with ADHD also may struggle with low self-esteem, troubled relationships and poor performance in school. Adolescents and adults with ADHD tend to develop coping mechanisms to compensate for some or all of their impairments. Although much progress has been made in our understanding of the diagnosis and treatment of ADHD, much has yet to be researched, particularly for adolescents. It is clear that the current diagnostic criteria, although valid for children, may need to be modified for adolescents and adults, to reflect the developmental changes that take place as children approach adulthood. Studies are required to clarify how medication needs, types, dosages, and frequencies of administration differ among adolescents and adults, compared with...
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Posted by admin on May 1, 2013 in |
Rapid rising population has caused serious problems in the economic growth and all around human development especially in developing countries like India. Our future well-being depends on increased access to family planning and reproductive health services and decreased consumption by people. Family planning has been promoted through several methods of contraception. But due to series adverse effects produced by synthetic steroidal contraceptives, attention has now been given to indigenous plants for possible contraceptive effects. Thus there is a need of replace these agents by plants. The investigation of plant constituents with development of an effective, reversible and safe male contraceptive represents a potential alternative approach to birth control from the existing available methods. This review concentrates on those recent advances in science and technology that offer possible inroads for shifting the paradigm for male-based contraception. This review presents updated information gathered on scientifically proved medicinal plant (Withania Somnifera) and their more than 50 secondary metabolites might be can use as male contraceptive agents and other biological activity. The aim...
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Posted by admin on May 1, 2013 in |
Peroxisome proliferator-activated receptors (PPARs) are nuclear transcription factors, and play a central role in insulin sensitivity, lipid metabolism, and inflammation. PPAR -γ appears to improve glycaemic control by increasing peripheral insulin sensitivity and reducing hepatic glucose production, thereby helping to preserve beta-cell function. However, they have modest beneficial effects on lipid parameters. It has been observed that fibrate drugs which activate PPAR- α, produce significant improvements in dyslipidaemia and decrease atherosclerotic lesions, but do not affect glycaemia. Theoretically, a compound targeting both α and γ PPARs simultaneously, might combine the benefits of thiazolidinediones (TZDs) and fibrates. Hence, there is a resurgence of interest in the development of new antidiabetic drugs that combine the insulin-sensitizing effects of PPARγ activation with the additional lipid-modifying activity of the other PPAR subtypes. Compounds that act on both receptors may represent an attractive treatment option, provided that the potential to improve both glycemic and lipid parameters can be achieved within the same therapeutic window in order to minimize the incidence of PPAR-related side effects....
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Posted by admin on May 1, 2013 in |
There are up to 25000 genes encoded by our genome however among them only some are being expressed on mass level. Some of these important genes are; ABO genes located at chromosome number 9, ALB genes located at chromosome number 4, BCL-2 genes located at chromosome number 18, CCR-5 genes located at chromosome number 3, CD4 genes located at chromosome number 12, CD8 genes located at chromosome number 2, IL10 genes located at chromosome number 1, IL2 genes located at chromosome number 4 and INS genes located at chromosome number 11. These above mentioned genes are important in the proper functioning of the body and any mutation in them could lead to different genetic...
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