Posted by admin on Apr 1, 2013 in |
Significant portion of maternal death in developing countries was attributed to induced abortions secondary to unwanted pregnancies. Using emergency contraception as a backup method can contribute to reduce unwanted pregnancy secondary to method failure, contraception non-use and also rape. The need for emergency contraception is clearly demonstrated by the occurrence of unwanted pregnancy and induced abortion. If emergency contraception were easily available and distributed through clinics and non-clinics channels along with appropriate advocacy activities millions of unwanted pregnancy and abortions could be averted. There is a growing concern about the prevention of unintended pregnancy and unsafe abortion to minimize maternal death and this review concentrates on accessibility barriers related to emergency contraceptives that limit its use among women of reproductive age...
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Posted by admin on Apr 1, 2013 in |
Indole ring system is the most important heterocycle available in natural compounds. Owing to great structural diversity, the indole ring system has become an important structural requirement in many pharmaceutical agents. Indole has been widely identified as a privileged structure or pharmacophore, with its presence in over 3000 natural isolates which are known to possess broad spectrum of biological activities and pharmaceutical applications. The bis (indolyl) methane derivatives are found to be very active compounds in pharmacy field. They are found in cruciferous plants and are known to promote beneficial oestrogen metabolism and induce apoptosis in human cancer cells. In recent years, a lots of bis (indolyl) methane derivatives have been synthesized and found to possess promising biological activities including anticancer, antimicrobial, antifungal, analgesic, anti-inflammatory, anthelmintic, cardiovascular activities. In the present review several synthetic schemes of these compounds are discussed involving non-toxic catalyst and providing high...
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Posted by admin on Apr 1, 2013 in |
Nasal route is found to be valuable for targeting drugs to CNS via different mechanisms. The advantages, disadvantages, varius aspects of nasal anatomy and physiology, mechanism of drug transport from nose brain, drug selection criteria to cross BBB/Blood-CSF barrier are discussed briefly. The relevant aspects of physicochemical, formulation and physiological factors of nasal cavity that must be considered during the process of discovery and development of new drugs for nasal delivery drugs as well as in their incorporation into appropriate nasal pharmaceutical formulations are discussed here. There are various approaches in delivering a therapeutic substance to the target site in a controlled release fashion. One such approach is using microemulsion as carriers for drugs. Microemulsions are isotropic, thermodynamically stable transparent (or translucent) systems of oil, water and surfactant, frequently in combination with a cosurfactant with a droplet size usually in the range of 10-100 nm. They can be classified as oil-in-water (o/w), water-in-oil (w/o) or bicontinuous systems depending on their structure and are characterized by ultra-low interfacial tension between...
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Posted by admin on Apr 1, 2013 in |
Substance abusers and drug addicts generally seek the fastest and most effective methods of getting high this means that drug delivery methods are important to users, and typically an addict will prefer one method over another. However, because there are a wide variety of drug delivery methods, substance abusers will often fluctuate between these techniques when the need arises. Understanding the different ways that people use drugs can aid in creating awareness and recognition skills to help combat drug abuse and...
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Posted by admin on Apr 1, 2013 in |
The development of sound Analytical method(s) is of supreme importance during the process of drug discovery, release to market and development, culminating in a marketing approval. The objective of this paper is to review the method development, optimize and validation of the method for the drug product from the developmental stage of the formulation to commercial batch of the product. Method development for the interested component in finished product or in process tests and the sample preparation of drug product and to provide practical approaches for determining selectivity, specificity, limit of detection, limit of quantitation, linearity, range accuracy, precision, recovery solution stability, ruggedness, and robustness of liquid chromatographic methods to support the Routine, in process and stability...
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