Posted by admin on Jan 1, 2013 in |
To provide an updated technical note on granulation technology (GT), mostly on novel GT, that will help researcher working/engaged in designing an efficient GT for getting granules with desired features. Granules were most widely used in the production of pharmaceutical oral dosage forms. Advancement in GT had revolutionized the sphere and resulted in development of several processes. Each and every process had advantages and disadvantages, and limitations. Depth knowledge in GT was a prerequisite to process product for obtaining targeted granulation with desired product parameters. In this regards updated literatures were collected from data bases, studied and was presented for easy reference of scientists engaged in granule production, so that they can adopt appropriate and suitable GT. Presented handy note will help researchers in designing a robust GT for getting optimised...
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Posted by admin on Jan 1, 2013 in |
Day by day there are new developments in field of colon specific drug delivery system. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon like Crohn’s disease, ulcerative colitis, etc. but also for the systemic delivery of proteins, therapeutic peptides, anti-asthmatic drugs, antihypertensive drugs and anti-diabetic agents. New systems and technologies have been developed for colon targeting and to overcome pervious method’s limitations. Colon targeting holds a great potential and still need more innovative work. This review article discusses, in brief, introduction of colon along with the novel and emerging technologies for colon targeting of a drug...
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Posted by admin on Jan 1, 2013 in |
Conformational analysis is an important step in molecular modeling as it is necessary to reduce time spent in screening of compounds for activity. Most drugs are flexible molecules with the ability to adopt different conformations by means of rotation about single bonds. Conformations play an important role in prediction of not just physico-chemical properties but also the biological activity of the drug. This review details the various methods involved in conformational analysis. The major objective of conformational analysis is to gain insight on conformational characteristic of drugs and also to identify the relation between the role of conformational flexibility and their...
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Posted by admin on Jan 1, 2013 in |
According to FDA estimates about 10% of all drugs sold worldwide are counterfeit. Annual global trade in counterfeit goods is estimated to be $600 billion and growing. Counterfeit goods and drugs leads real threat to consumer safety as well as loss of companies brand value and profits. Till date, dosage authentication required forensic analysis in a laboratory which is a slow process involving application of sophisticated equipment. Now days to avoid counterfeiting of products many companies are coming with various techniques of product authentication. One of the newest, innovative securities ways is by applying micro-tags to the dosage. Unlike forensic systems, micro tags can provide quick, reliable, economical identification and authentication of a drug product in the field within a few minutes, without destroying the product. Not only this much, end-users also can monitor the tags with a simple, inexpensive, hand-held detection system. Each tag is unique and cannot be reverse-engineered by a counterfeiter. Micro-tag provides safe, easily implementable, reliable means of authentication of...
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Posted by admin on Jan 1, 2013 in |
Cancer is the second leading cause of death worldwide. In USA three persons out of five will develop some type of cancer. Beyond these statistics of mortality, the morbidity due to cancer presents a real scary picture. Last 50 years of research has rendered some types of cancer curable, but still the major fear factor associated with this disease is unchanged. Animal models are classified according to the method of induction of cancer in the animal. Spontaneous tumor models are the most primitive models. Although these models show good resemblance to the natural disease in humans, they were not capable of keeping pace with developing experimental therapeutics programs. It has therefore been necessary to take a further step towards artificiality, away from the clinical problem in the search for satisfactory testing method. From this step, the journey of artificially induced tumor models started. It is possible to induce cancer reproducibly in animals by exposing them to various agents and now, by transplanting tumor cells or tissue. The development of...
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