Posted by admin on Dec 1, 2012 in |
Lycopene is a carotenoid that is present in tomatoes, processed tomato products and other fruits. It is one of the most potent antioxidants among dietary carotenoids. Dietary intake of tomatoes and tomato products containing lycopene has been shown to be associated with a decreased risk of chronic diseases, such as cancer and cardiovascular disease. Serum and tissue lycopene levels have been found to be inversely related to the incidence of several types of cancer, including breast cancer and prostate cancer. Although the antioxidant properties of lycopene are thought to be primarily responsible for its beneficial effects, evidence is accumulating to suggest that other mechanisms may also be involved. In this article we outline the possible mechanisms of action of lycopene and review the current understanding of its role in human health and disease...
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Posted by admin on Dec 1, 2012 in |
Artemisia annua L., also known as sweet wormwood, sweet annie, sweet sagewort and annual wormwood (Chinese: qngho), is a common type of wormwood that is native to temperate Asia, but naturalized throughout the world, and that belongs to the family of the Asteraceae. Currently, Artemisia annua is the source for the production of artemisinin and semi-synthetic artemisinin derivatives (including dihydroartemisinin, artesunate, artemether and arteether) that are used for the production of combination therapies for treatment of malaria (ACTs = Artemisinin-based Combination Therapy). Animal studies suggested that artemisinin and related compounds inhibit tumor growth and metastasis. However, there is no reliable evidence from clinical trials at the moment that effects from animal studies translate into benefits for cancer patients. Experiences from malaria treatment indicate a good tolerability of artemisinin-based drugs. However, there are two case reports with severe adverse effects if artemisinin-based drugs were used at higher...
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Posted by admin on Dec 1, 2012 in |
The chemistry of heterocyclic compounds containing five membered 1, 2, 4-triazole nucleus has been an intresting field of study for past few decades. The five membered 1, 2, 4-triazole ring exists in two tautomeric forms i.e., 1H-1, 2, 4-triazole, 4H-1, 2, 4-triazole collectively known as s-triazoles. The s-triazole derivatives possess extensive spectrum of biological activities such as antibacterial, antifungal, antitubercular, anxiolytic, anticonvulsant, anti-inflammatory, analgesic, anticancer, antioxidant activities. The present review provides a broad view of pharmacological activity of compounds bearing 1, 2, 4-triazole nucleus. It can be useful for medicinal chemists to design and develop novel compounds consisting 1, 2, 4-triazole nucleus to get better agents in terms of efficacy and...
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Posted by admin on Dec 1, 2012 in |
The eye is the most easily reachable organ available for topical drug delivery of local as well as interiorly acting drugs. Ideal drug delivery system aims to provide loading and maintenance dose of drug while being within therapeutic limits at the desired site of action for the desired period of time. In the treatment of ocular disease, the site of action is very narrow and undesired side effects may cause serious injuries to eye tissues. Thus, ideal ocular drug delivery should be site specific, controlled release and non-irritating. Many drugs (more than 85%) belong to BCS class IV exhibiting poor solubility and permeability. Moreover; the precorneal losses like tear secretion, naso-lachrymal drainage and less permeability of corneal tissue causes only 1% absorption of instilled dose. These limitations lead to increased loading dose and dosing frequency to maintain minimum therapeutic level for action which ultimately causes over exposure of drug to eye and leads to serious side effects. Due to these hurdles of conventional drug delivery system, the vesicular drug...
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Posted by admin on Nov 1, 2012 in |
Many herbal remedies have been employed in various medical systems for treatment and management of different diseases. The plant Oxalis corniculata Linn. has been used in different system of traditional medication for the treatment of diseases and ailments of human beings. β-sitosterol, betulin, 4-hydroxybenzoic acid, ethyl gallate, methoxyflavones, apigenin, and 7-O-β-D-glucopyranoside were previously isolated from the whole plant of Oxalis corniculata.linn. The review reveals that wide ranges of phytochemical constituents have been isolated from the plant like flavanoids, tannins, phytosterols, phenol, glycosides, fatty acids, galacto-glycerolipid and volatile oil. The leaves contain flavonoids, iso vitexine and vitexine-2”- O- beta – D- glucopyrunoside. It is rich source of essential fatty acids like palmitic acid, oleic, linoleic, linolenic and stearic acids. It has been reported that the plant contains anti-inflammatory, anxiolytic, anticonvulsant, antifungal, antiulcer, antinociceptive, anticancer, antidiabetic, hepatoprotective, hypolipedemic, abortificient, antimicrobial and wound healing properties. The current study is therefore reviewed to provide requisite phytochemical and pharmacological detail about the...
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