Posted by admin on Jul 1, 2012 in |
The coating of solid pharmaceutical dosage forms began in the 9th century B. C., with the Egyptians. Conventional coating techniques are based on solvents or water. Solventless coatings are alternative technique of coating. In solventless coating, the coating material is directly spread on the core and then it is cured by special method to form coat. Solventless coating avoids the use of water or it reduces to very small amounts with respect to the coating material hence it overcomes the limitations of conventional coating such as need for time, energy consuming, drying steps and the most important drug stability issues. A variety of solventless coating approaches are described in this review as powder coating, hot melt coating, supercritical fluid coating, magnetically assisted impaction coating, Plasma enhanced chemical vapor deposition. This review summarizes basic principle and process of the coating...
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Posted by admin on Jul 1, 2012 in |
The realization that reactive oxygen species and oxidative stress play an important role in the etiology and progression of major human degenerative diseases has triggered enormous and worldwide interest in endogenous and exogenous antioxidants. The 1990’s have seen the explosion of interest in antioxidants. The article reviews free radical chemistry, antioxidant systems & their role in human diseases with special reference to oral malignancies &...
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Posted by admin on Jul 1, 2012 in |
Transdermal Drug Delivery System (TDDS) is one of the systems lying under the category of controlled drug delivery, in which the aim is to deliver the drug through skin in a predetermined and controlled rate. Hypertension is one of the common disorder for the mankind. It is not a disease in itself, but is an important risk factor for cardiovascular mortality and morbidity. The present article delivers a brief view on the work been done to increase the bioavailability of various antihypertensive drugs by formulated and delivered as transdermal patches. The different drugs includes carvedilol, metoprolol, atenolol, propranolol, labetolol, verapamil, indapamide, losartan, bisoprolol, timolol maleate, nicardipine hydrochloride, captopril, clonidine, pinacidil, nitrendipine, nicorandil, diltiazem hydrochloride, lisinopril, nifedipine, amlodipine, valsartan, enalapril maleate....
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Posted by admin on Jul 1, 2012 in |
Apoptosis plays an important role in development, growth, differentiation, altered gravity conditions, tissue homeostasis, immune defense, and cancer to control cell number in tissues and to eliminate individual cells that threaten the animal’s survival. The purposes of this review are to describe the signaling pathways and the cellular changes that occur with apoptosis. Currently, two pathways for activating apoptosis have been studied in detail. One starts with ligation of a death ligand to its transmembrane death receptor, followed by recruitment and activation of caspases in the death-inducing signalling complex. The second pathway involves the participation of mitochondria, which release caspase-activating proteins into the cytosol, thereby forming the apoptosome where caspases will bind and become activated. The novel agents include those targeting for the design of more effective and selective therapeutic strategies. This review providing an overview of the recent understanding of apoptotic signaling pathways, the main mechanisms by which cancer cells resist apoptotic insults, and discuss some recent attempts to target for restoring efficient cell death signaling in cancer...
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Posted by admin on Jul 1, 2012 in |
In this article, an attempt has been made to explore a positive correlation between obesity and type 2 diabetes mellitus. The possible role of several important agents in causing both has been discussed in detail. From the discussion, it seems that obesity is definitely and intimately linked to type 2...
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