Posted by admin on Aug 1, 2011 in |
The present article is a descriptive study of the performances of ethosomes and proniosomes as specialized delivery systems for transdermal drug delivery system. Vesicular systems, such as ethosomes and proniosomes are used in cosmetic and pharmaceutical products to encapsulate ingredients, to protect ingredients from degradation, to increase bioavailability, and to improve cosmetic performance. A review of literature is presented here and a sincere attempt has been made to highlight the properties and characteristics of proniosomes and ethosomes in transdermal drug delivery and cosmetic/cosmeceuticals applications. Interaction studies between proniosomes and ethosomes components and skin is also discussed along with the formulation aspects of proniosomes and ethosomes formulation. Our aim is to introduce and explore proniosome and ethosomes as a carrier system for various applications of drugs and cosmeceuticals. The goal of this study is to investigate the efficiency of transcellular delivery of drugs with the help of ethosomes and...
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Posted by admin on Aug 1, 2011 in |
Melatonin, a pineal hormone is known to regulate rhythmic behavior of mammals. Its ubiquitous presence, established recently has brought into focus several health-promoting benefits of this molecule. However, till date, melatonin has been less utilized from its nutraceutical and functional point of view. This paper reviews the chemistry, chemical synthesis, metabolism of melatonin; its sources including its bioavailability from the same, its role in mammals and in plants and the analytical techniques for quantitative analysis of the same. The nutraceutical potential of melatonin and its functional properties have been elaborated. Melatonin’s function as a direct free radical scavenger endows it the potency to act as strong antioxidants- a property which needs to be further researched upon to establish its efficacy in food...
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Posted by admin on Aug 1, 2011 in |
In recent years scientific and technological advancements have been made in the research and development of oral drug delivery system. The reasons that the oral route achieved such popularity may be in part attributed to its ease of administration. Over the years, patient convenience and patient compliance-oriented research in the field of drug delivery has resulted in bringing out potential innovative drug delivery options. Out of which, medicated chewing gum (MCG) offers a highly convenient patient-compliant way of dosing medications, not only for special population groups with swallowing difficulties such as children and the elderly, but also for the general population, including the young generation. Today, medicated chewing gum meets the same high quality standards as...
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Posted by admin on Aug 1, 2011 in |
A dendrimer is described as a macromolecule, which is characterized by its highly branched 3D structure that provides a high degree of surface functionality and versatility. The unique properties of dendrimers such as uniform size, high degree of branching, water solubility, multiagency, well-defined molecular weight and available internal cavities make them attractive for biological and drug-delivery applications. These artificial macromolecules may be synthesized to reach the size of nano objects having dimensions similar to proteins. Recently dendrimers have successfully proved themselves as promising nanocarriers for drug delivery because they can render drug molecules a greater water-solubility, bioavailability, and biocompatibility. These features have made their application in pharmaceutical, nanotechnology and medicinal chemistry particularly attractive. In addition Nanoparticle drug-delivery systems are the popular ones as are able to increase the selectivity and stability of therapeutic agents. However reticuloendothelial system (RES) Uptake, drug leakage, immunogenicity, hemolytic toxicity, cytotoxicity, hydrophobicity restrict the use of these nanostructures. These shortcomings are overcome by surface engineering the dendrimers. Commercialization of dendrimers is now forthcoming. The present review...
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Posted by admin on Aug 1, 2011 in |
The nanoemulsion is one of the most efficient dispersed nanosystems of droplet size ranging to submicron size. Nanoemulsion are generally transparent or semi transparent system characterized by high stability. They are characterized by high stability. Submicron droplet size and high surfactant concentration makes it an efficient transdermal delivery vehicle. Research works proves that nanoemulsion is far more efficient drug delivery system than other transdermal drug delivery system. The efficacy of the nanoemulsion is enhanced by the nature and type of surfactant and co-surfactant used. Thus in this article ability of the nanoemulsion as a transdermal and topical delivery system is...
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