Posted by admin on Feb 1, 2012 in |
Diabetes is a major public health problem. Diabetes mellitus now affects large number of people in many developing countries than western countries where only two or three percent of the population is affected. With on estimated 33 million people in India alone affected by diabetes. It is a major epidemic of the twentieth century. Diabetes is a chronic disorder, which is associated with obesity, hypertension, advancing age, accumulation of harmful agents in the vascular endothelium causing development of microangiopathies or micro vascular complications. These complications include peripheral neuropathy, nephropathy and retinopathy, which cause early death and increased morbidity. These complications vary in prevalence in different populations depending on various factors such as genetic predisposition and ethnicity. Besides these complications cardiovascular changes are also occurring. Peripheral neuropathy (PN) is characterized by pain, numbness, and tingling in the extremities with slow nerve conduction. Up to 50% of all patients with diabetes develop neuropathy and the prevalence of painful neuropathy ranges from 10 to 20% of patients with diabetes. Diabetic nephropathy is...
Read More
Posted by admin on Jan 1, 2012 in |
Drug delivery technologies are patent protected formulation technologies that modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance .Delivery devices already exist that can release two drugs, but the timing of the release must be built into the device and it cannot be controlled from outside the body. But the new system gold nanoparticles are controlled externally and theoretically could deliver up to three or four drugs. When a drug is administered, the dosage must be carefully calculated so that the body can use the drug, which requires a drug delivery system which allows for precise dosing. Drug delivery systems also need to consider the way in which a drug is metabolized by the body. For example, some drugs are destroyed in the intestinal tract, which means that they cannot be introduced to the body in this way. Others may be dangerous in large amounts, which mean that a time release method should be...
Read More
Posted by admin on Jan 1, 2012 in |
Stem cell research has been hailed for the potential to revolutionize the future of medicine with the ability to regenerate damaged and diseased organs. On the other hand, stem cell research has been highly controversial due to the ethical issues concerned with the culture and use of stem cells derived from human embryos. This article presents an overview of what stem cells are, what roles they play in normal processes such as development and cancer, and how stem cells could have the potential to treat incurable diseases. Ethical issues are not the subject of this review. In addition to offering unprecedented hope in treating many debilitating diseases, stem cells have advanced our understanding of basic biological processes. This review looks at two major aspects of stem cells. Three processes in which stem cells play a central role in an organism, development, repair of damaged tissue, and cancer resulting from stem cell division going awry. II. Research and clinical applications of cultured stem cells: this includes the types of stem...
Read More
Posted by admin on Jan 1, 2012 in |
Cephalosporins are the most important type of antibiotics used vary widely. Analysis of these antibiotics is challenge because of their sensitivity and instability to different conditions. The present review is extended to find out different HPLC methods used for analysis for cephalosporins in formulations and biological fluids. The chromatographic conditions used for the analysis as well as analytical parameters study carried out with different experimental conditions and different combinations. During the study analytical parameters studied such as range, linearity, precision, accuracy, LOD, LOQ etc. The focus of study of analysis of cephalosporin in formulation and biological fluid are useful for the determination of various cephalosporin for budding...
Read More
Posted by admin on Jan 1, 2012 in |
Vitamin A is an essential vitamin which is required in the vision process, epithelial maintenance, mucous secretion and reproduction obtained from carotenoids. Carotenoids have been considered to provide benefits in age-related diseases, against some forms of cancer (in especial lung cancer), strokes, macular degeneration, and cataracts. Till date, more than 600 carotenoids are known and 50 of them are consumed in meals to be transformed into the essential nutrient vitamin A. After their absorption, these carotenoids are metabolized by an oxidative rupture to retinal, retinoic acid and small quantities of breakdown products and are transported by plasma lipoproteins. Carotenes are mainly associated with low-density lipoproteins, while xanthophylls show a uniform distribution between the low- and high-density lipoproteins. The present review provides an insight into the recent status of pharmacological aspects of...
Read More
