Posted by admin on May 1, 2011 in |
Momordica charantia Linn. which has been used mainly for edible purposes at different countries of the world including South East Asia and has also been extensively used in traditional medicines for the cure of various ailments. M. charantia belongs to the cucurbitaceae family. Extensive research has been carried out on the fruit, leaves, and seeds of the plant. Most importantly, all these research works have shown its efficacy on various cancer cell lines like lymphoid leukemia, lymphoma, choriocarcinoma, melanoma, breast cancer, skin tumor, prostatic cancer, squamous carcinoma of tongue and larynx, human bladder carcinomas and on Hodgkin’s disease. Clinical reports of some research on the use of M. charantia in diabetes and cancer patients showed promising results. The main active constituents of M. charantia are cucurbitane type triterpenoids which have some potent biological and pharmacological activities including antidiabetic, anti-obesity, anticancer, anti-HIV, anti-feedant and anti-oviposition activities. Since in the early 1960’s the constituents of M. charantia have been investigated and several classes of secondary metabolites including cucurbitane-type triterpenoids, glycosides and...
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Posted by admin on May 1, 2011 in |
Rheumatoid arthritis (RA) is an aggressive disease that needs to be treated effectively if subsequent deformity and disability are to be reduced. A recent advance in the management of RA is the use of biological agents which block certain key molecules involved in the pathogenesis of the illness. They include tumor necrosis factor (TNF-a) – blocking agents, Anti-Interleukin-1receptor (IL-1) antagonist, anti-CD-20 agents, CTLA-4 Ig, anti IL-6 etc. These newer agents proved to be useful for alleviating symptoms and slowing the disease progression in the patients with RA who have failed to respond to conventional disease modifying anti-rheumatic drugs (DMARDs). DMARDs are nonspecific immunomodulators, each of which has substantial drawbacks in terms of effectiveness or adverse effects (AEs). The development of biologic agents has provided more effective therapeutic options. The terms biologic therapies and biologics have emerged to describe agents with biologic properties, including monoclonal antibodies and soluble cytokine receptors etc. The advent of effective biological agents has certainly been a major advance in the treatment of inflammatory arthritis, heralding...
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Posted by admin on May 1, 2011 in |
The manufacture of bi-layer tablets, produced by the sequential compaction of loose powder layers has recently become of increased interest within the pharmaceutical industry due to the tailored release profiles of active ingredients that may be obtained. In a bi-layer configuration, the immediate release layer of the bi-layer tablet has worked as the loading dose and the sustained release layer has maintained the therapeutic plasma drug concentration for prolonged time. Several pharmaceutical companies are currently developing bi-layer tablets, for a variety of reasons: patent extension, therapeutic, marketing to name a few. To reduce capital investment, quite often existing but modified tablet presses are used to develop and produce such tablets. This article explains why the development and production of quality bi-layer tablets needs to be carried out on purpose-built tablet presses to overcome common bi-layer problems, such as layer-separation, insufficient hardness, inaccurate individual layer weight control, cross-contamination between the layers, reduced yield, etc. Using a modified tablet press may therefore not be your best approach in producing a quality...
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Posted by admin on May 1, 2011 in |
Carbon nanotubes are the technology that imagination by many scientists in the different country. There are small strengths, dimensions, and the remarkable physical properties of the carbon nanotubes that structures make a very unique material with a whole range of various applications. There are discussing some of the important application of materials science use in carbon nanotubes. There are discuss the pharmaceutical applications of nanotubes, electronic and electrochemical application of nanotubes, mechanical strengths of nanotubes in high performance composites and field emitters based upon nanotube. There are another application of nanotubes such as metrology and biological application of nanoprobes and chemical investigations and formation of other nanostructures. Applications of nanotubes device and electronic properties was treated in the book. The challenges that happen after wards in act of realizing then some applications such as manufacturing, processing, and cost considerations are discussed in the various points of view. Carbon nanotubes are widely applicable in the pharmaceutical field for the treatment of many types of...
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Posted by admin on May 1, 2011 in |
Dendrimers are unique class of the polymer which is characterized by its extensively branched 3D structure that provides a high degree of surface functionality and versatility. Many drugs used in various therapies are facing difficulties like toxicity or nonspecific targeting. New delivery technologies could help to overcome this challenge. Nanostructures with uniform and well-defined particle size and shape are of eminent interest in biomedical applications because of their ability to cross cell membranes and to reduce the risk of premature clearance from the body. Hydrophobic drugs can be complex within the hydrophobic dendrimers interior to make them water-soluble or drugs can be covalently coupled onto the surface of the dendrimers. Structural features of this nanomolecule can be effectively modified for drug delivery in the field of pharmaceutical sciences and biotechnology. Present review deals with various applications along with relevant examples of dendrimers in brief....
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