Posted by admin on Jun 1, 2010 in |
Breast Cancer is the leading cause of mortality among the women of age 30 to 60. Endocrine therapy used for the treatment has shown promising results in which the anti-estrogen tamoxifen has been the standard first-line treatment used for more than 30 years. But its side effects like resistance, increase risk of thromboembolism, endometrial cancer and uterine sarcoma limits its use. The development of selective Aromatase Inhibitors has offered an alternative approach for postmenopausal patients failing anti-estrogen therapy alone or other hormonal therapies. These drugs are approved as first-line therapy for the treatment of postmenopausal women with metastatic estrogen-dependent breast cancer. They are proven superior to tamoxifen for disease free survival, especially in receptor positive patients and reducing the incidence of colorectal breast...
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Posted by admin on Jun 1, 2010 in |
Coconut oil is said to be healthiest oil on the earth because it is used not only diabetes but it is also used to reduce weight, risk of atherosclerosis, risk of cancer, prevents bacterial, viral and fungal infections, improves digestion and nutrient absorption etc. Diabetes is all about sugar, the sugar in our bodies known as blood sugar or blood glucose. There is one fat that diabetics can consume without fear. That fat is coconut oil. It helps to regulate blood sugar. Coconut oil helps in supply of energy to cells because it is easily absorbed without the need of enzyme or insulin. Coconut oil in the diet enhances insulin action and improves binding affinity compared to other oil. It is a natural antioxidant. It protects the body from free radical damage and prevents premature aging and degenerative disease. Coconut oil is best massage oil on the planet. It forms a barrier against infections, softens and moisturizes our skin and prevents wrinkling, sagging and age spots. It promotes healthy...
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Posted by admin on Jun 1, 2010 in |
The task of achieving efficient delivery of drugs that have poor bioavailability or narrow absorption windows have plagued the pharmaceutically industry for decades. Thus, much research has been dedicated to the development of novel polymeric-based gastro retentive drug delivery technologies that may optimize the bioavailability and subsequent therapeutic efficacy of such drugs. Several technical approaches are currently utilized in the prolongation of gastric residence time, including high-density, swelling and expanding, polymeric mucoadhesive, ion-exchange, raft forming, magnetic and floating drug delivery systems, as well as other delayed gastric emptying devices. The purpose of writing this review on gastro retentive drug delivery systems was to compile the recent literature with special focus on various gastro retentive approaches that have recently become leading methodologies in the field of site-specific orally administered controlled release drug delivery. In this review, the current technological developments of FDDS and marketed products have been discussed. In addition, the pharmaceutical basis of their design, their advantages and future potential for oral controlled drug delivery are...
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Posted by admin on May 1, 2010 in |
Hypertension is a common problem facing many peoples today. Although billions of dollars are spent annually for the treatment and detection of cardiovascular disease, current conventional treatments have done little to reduce the number of patients with hypertension. Alternative medicine offers an effective way to decrease the rising number of people with high blood pressure. Research has found a variety of alternative therapies to be successful in reducing high blood pressure including diet, exercise, stress, management, supplements and herbs. Every year, more and more studies are being performed on herbal remedies for high blood pressure. There are many herbal drugslikePunarnava, Barberry, Rouwolfia, Garlic, Ginger, Ginseng and Arjuna which can safely use for the treatment of hypertension. This review highlight the herbs proved scientifically for the treatment of...
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Posted by admin on May 1, 2010 in |
Despite of tremendous advancement in drug delivery the oral route of drug administration is the most important method of administration of drug for systemic effect. The parenteral route is not routinely used for self administration of medication. It has been known for centuries that buccal and sublingual administration of drug solute is rapidly absorbed into the reticulated vein, which lies underneath the oral mucosa. The oral mucosa has rich blood supply and it is relatively permeable. The permeability of the buccal mucosa is 4- 1000 time greater then that of skin. the administration of drugs by the buccal route has several advantage over per oral administration such as QWICK ACTION, avoid of first pass metabolism , drug is not subject to acidic environment of the stomach and also the improved patient compliance particularly with pediatric & geriatric patient. It is the objective of this article to review the oral mucosal drug delivery by discussing briefly the structural feature of mucosa as drug delivery such as buccoadheshive film & tablet,...
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