Posted by admin on Dec 1, 2010 in |
Antibiotics have a well-documented efficacy in the treatment of established infections and as prophylactic agents in medically compromised patients. Antibiotics use is suggested to be a major risk factor for development of antibiotic resistance. Resistance to antimicrobials is emerging at an alarming rate that has reduced treatment options for nearly every pathogen infecting humans. Many bacteria now display a variety of mechanisms that help protect them during antimicrobial exposure. These include production of β-lactamases and cephalosporinases, alterations in penicillin-binding proteins, multidrug efflux pumps, transferable resistance to vancomycin, and mutations in genes encoding DNA gyrase. This article gives information about how bacteria develop antibiotic resistance, new era of antimicrobial therapeutics and new strategies to eliminate antibiotic...
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Posted by admin on Nov 1, 2010 in |
Emerging nanomedicine technologies could dramatically transform medical science as we know it today with their potential to address unmet medical needs and provide targeted therapy. Nanomedicine technologies could find an increasing place in various areas and applications of the healthcare sector including drug delivery, drug discovery and development, diagnostics and medical devices. The advent of nanomedicine and techniques for the early diagnosis of diseases could usher in a new era of superior prophylactic or preventive medicine. By using preventive medicine, treatment for diseases could be initiated even before preliminary symptoms appear. Prophylactic interventions might help postpone or even avoid diseases altogether. Nanomedicine could therefore have a huge impact on people’s lives, substantially improving their physical health and quality of life. Nanocrystal technology, for instance, is being used in drug formulation and the new chemical entities screening in the discovery phase of drug development. Quantum dot particles are being applied in high-content drug screening and in the detection of breast cancer cells among others. However, as with other new technologies,...
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Posted by admin on Nov 1, 2010 in |
Herbal medicines make up an important module of the fashion toward alternative medicine. It is becoming ever more popular in today’s world as people seek out for natural remedies. These medicines have been used since the dawn of civilization to maintain health and to treat various diseases. To compete with the growing pharmaceutical market, there is an exigency to develop and scientifically validated more medicinally useful herbal products. This review provides an outline of herbal medicines which is aimed to depict out pharmacovigilance, including standardization of these herbal...
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Posted by admin on Nov 1, 2010 in |
In recent time, scientific investigations of medicinal plants using indigenous medical systems has attracted a lot of attention globally. Nature has bestowed our planet with an enormous wealth of medicinal plants have been known for millennia and are highly esteemed all over the world as a rich source of therapeutic agents for the prevention and cure of diseases and ailments. Inflammation is complex biological response of vascular tissue due to different harmful stimuli and pain is discomfort signals result of actual or potential injury to the body may associate with inflammation. Inflammation with pain is associated with different diseases like rheumatism, encephalitis, pneumonia, oesophagitis, cancer, heart problems, fibrosis etc. Nonsteroidal anti-inflammatory drugs and opioid analgesic are normally used in the treatment of inflammation and pain but can cause a lot of adverse effect. Therefore herbal drugs can be potential source to replace them. Every year a lot of plants form traditional medicinal system has been screened for their potential anti-inflammatory and analgesic activity but only few of them only...
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Posted by admin on Nov 1, 2010 in |
Pelletization methods like solution layering, suspension layering or powder layering and extrusion-spheronization process is the most frequently used method for producing spherical pellets which utilizes a granulating liquid such as water, requires drying steps which is time consuming. Many drugs exhibit stability problem due to the presence of water during processing and residual water during storage. In addition to that pellets produced by these techniques exhibit rapid drug release and require a film coating to provide controlled release properties. Hot melt extrusion and freeze pelletization technique is receiving a great deal of attention as alternative technique over other techniques which need water during processing and drying steps. This article reviews the recent finding in the preparation of pellets by these novel...
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