Posted by admin on Sep 30, 2024 in |
Drug-delivery systems designed for specific targets allow drugs to be precisely delivered to areas affected by diseases. Various carriers are used to deliver drugs, including immunoglobulins, serum proteins, synthetic polymers, liposomes, niosomes and microspheres. In the last decade, there has been a considerable amount of interest directed towards the advancement of surfactant-based vesicles (known as Niosomes) for the purpose of improving drug delivery. Niosomes are self-assembled vesicular nanocarriers that are produced when cholesterol, non-ionic surfactant, or other amphiphilic compounds are hydrated & having a range of applications, including brain-targeted delivery and cutaneous delivery. Similarly to liposomes, niosomes can carry lipophilic and hydrophilic cargoes due to their bilayer structure. A vast number of research articles have been published on their manufacturing methods and applications in pharmaceuticals and cosmetics. Furthermore, niosomes may be created using simple procedures, need lower production costs, and are viable for extended periods of time, thus eliminating the fundamental limitations of liposomes. This review provides an overview of the present status of niosomal research, including the development...
Read More
Posted by admin on Sep 30, 2024 in |
The review paper comprehensively explores the immunomodulatory potential of Bauhinia variegata flower extract, a traditional medicinal plant renowned for its therapeutic properties. With a focus on its rich history in traditional medicine systems and its diverse pharmacological activities, the paper delves into the botanical and chemical composition of the extract, highlighting key bioactive compounds such as flavonoids, alkaloids, tannins, and phenolic compounds. It meticulously outlines the morphological characteristics of Bauhinia variegata flowers and its traditional medicinal uses, shedding light on its significant role in treating various health ailments. Moreover, the paper meticulously examines the intricate mechanisms underlying the extract’s immunomodulatory effects, including modulation of cytokines, activation of immune cells, antioxidant activity, and regulation of immune signaling pathways. Through in-vitro, in-vivo, and ex-vivo studies, the extract’s ability to enhance immune responses, alleviate inflammation, and mitigate immune-related disorders is thoroughly elucidated. Furthermore, the review offers a glimpse into future perspectives, advocating for continued research to identify specific bioactive compounds, elucidate underlying mechanisms of action, explore synergistic interactions with other drugs, and...
Read More
Posted by admin on Sep 30, 2024 in |
Thrombocytosis is defined as platelet count greater than 400, 000/mm3. Thrombocytosis can be either primary or secondary. Meropenem is a parenteral carbapenem antibiotic that has great bactericidal activity against almost all significant aerobes and anaerobes. Common adverse effects such as pain at the injection site, skin rash, transitory metabolic disorders such as increased liver enzyme levels, increased creatinine blood levels, or increased urea levels, or hematological disorders (thrombocytosis, eosinophilia) may be observed. Thrombocytosis due to Meropenem is relatively rare and here we report one such case of Meropenem induced thrombocytosis in a 26-year-old patient post cesarean delivery. A 26-year-old primigravida with 38 weeks gestation presented in labour for four hours. Her investigations revealed hemoglobin of 10.3, deranged LFT and thrombocytopenia. A provisional diagnosis of primigravida with 38 weeks gestation with Fetal Growth Restrictionwith jaundice, thrombocytopenia (TTP) in latent phase of labour was made. Later, the patient was taken up for emergency caesarean in view of fetal distress. Postoperatively the patient was given injectable ceftriaxone and metronidazole. Patient developed high grade fever (101 -103 F) on day 4 for...
Read More
Posted by admin on Sep 30, 2024 in |
Apart from the API, the excipient plays a crucial role in a formulation because of their versatile application, which enhances different physical and chemical characteristics in a dosage form. At present scenario natural polymers are considered a leading constituent as an excipient to formulate several innovative approaches for designing the drug delivery system. The components which are obtained from nature is always preferred for our health due to their fewer side effects. Hence, biopolymers have the additional privilege of being incorporated as an excipient in pharmaceutical formulations. Demand for natural polymers is enhancing day by day (increased 7.1% in every year as per scientific data) because of their versatile application in drug delivery systems and multiple utilization of several domains in the biomedical section. Low toxicity, compatibility, sustainability, biodegradability, swelling index, release pattern are the major Parameters of the biopolymers which alter the different pharmacokinetic and pharmacodynamic characteristics of a pharmaceutical dosage form. The major aim of this current review is to impart some knowledge related to the widespread...
Read More
Posted by admin on Sep 30, 2024 in |
A developing class of medications called biosimilars is created to be used interchangeably with biologics. In living cells, biologics are often large, complicated proteins with a range of potential applications. Biologics are utilised to treat malignancies, endocrine problems, and inflammatory bowel diseases just within the discipline of gastroenterology. Despite the fact that many diseases can be effectively treated or managed with biologics, patient access is frequently constrained by their high cost. The creation of biosimilars is an effort to lower the cost of medical care. In terms of efficacy, side effect risk profile, and immunogenicity, biosimilars must be essentially equivalent to their reference biologics. Biosimilars go through fewer clinical trials than their reference biologics, despite the manufacturing process still requiring manufacture within living cells. As a result, the biosimilar medication is less expensive to produce and purchase than the reference biologic. Seven biosimilars have currently received FDA approval for use in the treatment of Crohn’s disease, ulcerative colitis, and colorectal cancer. There are further biologics used to treat gastroenterological...
Read More
