Posted by admin on Apr 30, 2024 in |
This review explores the multifaceted roles of Src kinases, a subfamily of non-receptor tyrosine kinases, shedding light on their involvement in diverse diseases. Src-family protein tyrosine kinases (SFKs) exhibit widespread expression across various cell types, influencing their behavior and functionality. Src’s presence in distinct subcellular locations, such as plasma membranes, perinuclear membranes, and endosomal membranes, underscores its versatility and potential impact on cellular processes. Research indicates a significant association between SFKs and various disorders, emphasizing their relevance as potential therapeutic targets. The intricate interplay of SFKs in cellular membranes suggests a nuanced role in disease pathogenesis. The comprehensive examination of Src kinase’s involvement in different cellular contexts contributes to a better understanding of its potential implications in disease development. In conclusion, this study underscores the pivotal role of Src kinase and positions it as a promising therapeutic target for addressing a spectrum of illnesses. By elucidating the intricate mechanisms through which SFKs operate in cellular membranes, this review advocates for further exploration of Src kinases as crucial players in...
Read More
Posted by admin on Apr 30, 2024 in |
The need to deliver pharmaceuticals to patients quickly and with minimal side effects has driven pharmaceutical companies to invest in the development of novel drug delivery systems. Solid dose forms, such as pills, are difficult for pediatric and geriatric patients to swallow. The best treatment for this issue is a mouth dissolving pill that dissolves or disintegrates quickly in the oral cavity. Additionally, they produce a pleasant tongue sensation. ODT has benefits like enhanced Bioavailability, rapid action, and patient compliance. As a result, mouth-dissolved tablets are a desirable substitute for liquid and traditional tablet dose forms. In recent past, several manufacturing technologies such as sublimation technique, spray drying technique etc. are employed to overcome the limitations of conventional tablet dosage forms. The mouth dissolving tablets must undergo a variety of evaluations after they are created in order to ensure their long-term stability and improved therapeutic...
Read More
Posted by admin on Apr 30, 2024 in |
Wound infections persist as a significant and persistent challenge within the realm of healthcare, posing numerous detrimental consequences that extend far beyond the affected individuals. These infections, characterized by the infiltration of harmful microorganisms into wounds, encompass a multifaceted predicament that engenders slower healing periods, heightened morbidity rates, and an onerous financial burden on healthcare systems worldwide. Bacteriophages often known as phages, are viruses that selectively target and eradicate bacteria, making them a potentially effective alternative or supplementary treatment for wound infections. This article gives a general summary of what is currently known about using bacteriophages topically to treat wound infections. It goes through the fundamentals of phage treatment, looks at the benefits and drawbacks of phage use, examines the preclinical and clinical data that is now available, and identifies future research paths in this area. The review highlights the potential of bacteriophage-based therapeutics to transform the treatment of wound infections and provides information on the crucial factors to take into account for effective...
Read More
Posted by admin on Apr 30, 2024 in |
The utilisation of electroceuticals in the treatment of Parkinson’s disease is the predominant topic of discussion in this review. Electroceuticals, which are frequently referred to as “bioelectronics medicine,” are the result of the utilisation of electrical impulses for the goal of therapeutic treatment. It has been investigated if electroceuticals could serve as an alternative or adjuvant to the conventional pharmaceutical therapies that are used in the treatment of Parkinson’s disease. The purpose of this review is to conduct a comprehensive analysis of the existing literature concerning a variety of electroceutical modalities. These modalities include deep brain stimulation (DBS), vagus nerve stimulation (VNS), and transcutaneous nerve stimulation (TNS), amongst others. An analysis is performed to determine the efficacy and safety of various methods, as well as to determine their limitations and potential future research areas. While the review comes to the conclusion that electroceuticals have the potential to be an advantageous addition to the arsenal of Parkinson’s disease treatments, it is important to note that further research is required to...
Read More
Posted by admin on Apr 30, 2024 in |
The objective of chronotherapy is to optimize medical treatments taking into account the body’s circadian rhythms. Drug delivery systems that precisely control the release rates or target drugs to a specific site have an enormous impact on the health care system. Over the past few years, pharmaceutical industry has focused its research in the development of various Chrono therapeutic delivery systems. By choosing the optimal time to achieve the desired effect, treatment opportunities may arise, and undesirable side effects minimized. Hence, the long-term interest of both the public and the industry is to develop new and more effective methods on the current study focus – Chrono pharmaceuticals. The present article covers findings about the effects of biorhythms on various disorders, and their implications for drug therapy and also the design of novel chrono pharmaceutical drug delivery systems that might be able to release the therapeutic agents at predetermined...
Read More
