Posted by admin on Mar 31, 2024 in |
This systematic review provides a comprehensive overview of recent advancements in liquid crystalline nanoparticles (LCNs) utilized for transdermal drug delivery systems. Recent literature indicates a surge in research emphasizing lipid carriers derived from glyceryl monooleate and monoolein. The inherent nanostructure of LCNs offers superior solubilization capacity for bioactive molecules and controlled release mechanisms. This study underscores the potential of the cubic phase in LCNs as an innovative avenue for sustainable Transdermal Drug Delivery Systems (TDDS). Recent studies highlight the growing interest in cubosomes and hexosomes. Critical analysis necessitates further exploration into the therapeutic efficacy of Alpha lipoic acid cubosomes for anti-wrinkle applications, and the viability of hexagonal phase nano dispersions for in vivo peptide and siRNA delivery. A bibliometric assessment points out China as the leading contributor to LCN-centric publications. To summarize, LCNs are poised as potent TDDS, warranting future exploration in live skin imaging and immunological evaluations in animal model studiesproperties thus increasing residence time of drug with better patient...
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Posted by admin on Mar 31, 2024 in |
Plants have been the major source of drugs in Ayurveda and other ancient system in world. The Ayurveda, Siddha, Unani, Homeopathy systems have evidenced the use of plants for various disorders. Medicinal constituents from plants playa vital role in traditional as well as western medicine. Acalypha indica L. belongs to family Euphorbiaceae and is a common weed found in Asia, including India, Pakistan, Yemen, Srilanka and is well distributed in tropical areas of Africa and South America. Plant has emetic, expectorant, laxative and diuretic property, useful in bronchitis, pneumonia, pulmonary TB, Asthma, leaves are laxative, anti- parasiticide and possess antifungal activities. The plant possesses various pharmacological activities such as anti-inflammatory, antimicrobial, anti-ulcer, analgesic, anti- arthritic, HIV-1 reverse transcriptase inhibitory, antiurolithiatic, cytotoxic, anthelmintic, anticonvulsant, antianxiety, anti-malarial, lipid lowering, anti-venom and kidney protective activity. The present review gives a detailed survey of the literature on its phytochemistry, pharmacognosy, traditional uses and pharmacological...
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Posted by admin on Mar 31, 2024 in |
Oxalis corniculata is a perennial weed which is found in both tropical and temperate climates, it grows in damp and shaded areas throughout the Himalayas and warmer regions of India. This herb, an invasive weed has a number of valuable secondary metabolites. Numerous research has demonstrated the advantages of Oxalis corniculata leaf extract. Its metabolite profile, phytochemical analysis and therapeutic potential of its leaf extract are reviewed. To find diverse research relating to the utilization of this plant extract, a bibliographic search was done. Known bioactive compounds include oleic, linolenic, linoleic, stearic and palmitic acids, tannins, volatile oil, proteins, amino acids, phenolic compounds, phytosterols, flavonoids and carbohydrates. Several reports have revealed that it is considered as a weed, yet leaf extract has a wide range of benefits because of its pharmacological actions. Several pharmaceutical actions comprise of antimicrobial, antioxidant, wound healing, antifungal, antidiabetic, anticancer, antidiarrheal, antiulcer, anti-inflammatory, antiamoebic, hepatoprotective, nematocidal and cardio-protective. This review paper summarizes all the medicinal aspect and remedial uses of Oxalis corniculata, a traditional Indian...
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Posted by admin on Feb 29, 2024 in |
Trace elements are the dietary factors required by the body in small quantities for normal functioning of the body. The body’s functional skill is negatively impacted by a diet with insufficient trace elements, which lowers the body’s immune function. They are involved in catalyzing different enzymatic reactions. The permissible range of selenium is very narrow. Low levels of selenium have been reported in patients suffering from both acute and chronic kidney diseases. Reduced levels of selenium have also been reported in diabetic patients, while excess levels of selenium have been linked with inflammation and increased oxidative stress. Selenium at optimum amounts decreases oxidative stress by functioning as a cofactor of glutathione peroxidases and thioredoxin reductases. Insufficient intake of chromium leads to reduced insulin activity, hinder protein synthesis thereby leading to Type 2 diabetes mellitus. Chromium have been reported to boost enzyme activity and play crucial role in carbohydrate metabolism, increase sugar metabolism by initiation of insulin. This review aims to encompass the mechanism of action in prevention of diabetes...
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Posted by admin on Feb 29, 2024 in |
Camellia sinensis has been used since several decades owing to its numerous health benefits. The purpose of this study is to investigate the developments in new varieties of Camellia sinensis. This new variety of tea possesses striking, purple-colored leaves, and hence, it is more commonly referred to as purple tea. This study analyzes the detailed mechanism of color change. An over-expression of genes in C. sinensis leads to an increase in the proportion of its anthocyanin content which is responsible for its color change. The genes accountable are CsAN1 (R2R3-MYB transcription factor), CsGL3 and CsEGL3 (bHLH transcription factor) and CsTTG1 (WD repeat protein). This feature stimulated us to review purple tea. The review article discusses its history, taxonomy, geography, process of cultivation and collection with the appropriate harvesting seasons, macroscopic and microscopic characteristics, and its extraction processes. The constituents obtained from Camellia sinensis and the chemical structures of its phytoconstituents were also discussed. The therapeutic properties like anti-diabetic, anti-allergic, anti-pyretic, anti-inflammatory, anti-oxidant anti-aging and anti-parasitic associated with C. sinensis...
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