Posted by admin on Dec 31, 2023 in |
Cerium oxide nanoparticles, also known as Nanoceria, have attracted a lot of attention due to their remarkable catalytic activities, which result from a rapid and efficient modification of the oxidized state between Ce4+ and Ce3+. The cerium atom may quickly and dramatically change its electrical arrangement to better suit its immediate surroundings. It also has oxygen vacancies, or flaws, in the lattice structure, which result from the loss of oxygen and/or its electrons during redox processes, alternating between CeO2 and CeO2 x. Being a mature engineered nanoparticle with a variety of industrial applications, it was recently discovered to have multi-enzyme, including reactive oxygen species oxidase, catalase, and oxidase, mimetic properties that produce a variety of biological effects, including being potentially anti – oxidants towards almost all toxic and harmful intracellular reactive oxygen species. In biological domains such as bioanalysis, biomedicine, drug carriers, and bioscaffolding, nanoceria has emerged as an intriguing and valuable material. This review paper gives a thorough overview to nanoceria nanoparticles and their manufacture, multi-enzyme-like activity, prospective...
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Posted by admin on Dec 31, 2023 in |
Dry eye disease (DED) is one of the most common conditions in today’s digitalized society. DED is associated with decreased tear production, an unstable tear film, and ocular inflammation. Due to the COVID-19 pandemic, the use of digital screens (computers, laptops or smartphones) for work, study or entertainment has increased. As a result, the constant use of digital screens affects the eyes and makes everyone, including youth in the modern era, more susceptible to dry eye disease (DED). Alterations in mucin production are considered one of the most important causes contributing to dry eye disease. MUC5AC, a gel-forming mucin, acts as a surface active agent on the ocular surface and facilitates an evenly distributed tear film that moisturizes the conjunctival epithelium. The prolonged use of artificial tears and other allopathic medications results in specific adverse effects. Therefore, dietary nutrient intake and nutraceutical supplementation with active ingredients can be considered a safe and effective therapy for the treatment of dry eye disease. In conclusion, this review focused on some nutrients...
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Posted by admin on Dec 31, 2023 in |
Millions of people throughout the world suffer with epilepsy, a neurological illness that frequently results in seizures. Epilepsy has been treated using both allopathic and ayurvedic medicinal methods. Antiepileptic medications (AEDs) are used by allopathic medicine, commonly referred to as contemporary medicine, to manage seizures. Several AEDs have been created recently in allopathic medicine, such as Brivaracetam and Perampanel, which have better effectiveness and safety than earlier AEDs. Background: Approximately 1% of the global population suffers from epilepsy, a neurological illness marked by recurring seizures. Epilepsy is a difficult condition to manage despite improvements in medical technology, with up to 30% of patients still experiencing seizures while receiving antiepileptic medication (AEDs). Conclusion: Epilepsy is increasingly being treated with both allopathic and ayurvedic therapy. There are several ongoing clinical trials for the treatment of epilepsy using both allopathic and ayurvedic drugs. Because it is more practical for their busy lifestyles, has a quick mechanism of action, and is readily accessible, allopathy therapy is preferred by many...
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Posted by admin on Dec 31, 2023 in |
CADD is a powerful method to discover possible therapeutic compounds in conventional drug discovery. It has now surpassed all other high-throughput screening options, commonly used in drug discovery and development. The creation and optimization of several clinically utilized medications have significantly advanced thanks to CADD, or computer-aided drug design. Computer-aided drug design can take one of two methods: (1) Ligand-based (Analogue based) or (2) Structure-based (Target Based). All of these methods rely on MM force fields to represent atomic-level interactions and define molecular shapes, energy, and motion. The two most common approaches to drug design are structure-based drug design and ligand-based drug design. We can learn about drug-receptor interactions from it. Structure-based drug design includes the discovery of binding sites as well as docking and stocking, virtual screening, compound selection, and lead optimization. Quantitative structure-activity relationships (QSAR), pharmacologic modeling and other processes are aspects of the structure-based drug design process. As can be seen, CADD assists in recognizing appropriate pharmacological properties and compatibility to get an advantage in pre-clinical...
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Posted by admin on Dec 31, 2023 in |
Introduction: This paper will provide an overview of the uses, advantages and disadvantages of using ChatGPT in the pharmacy. A new era of personalised and interactive learning is beginning in pharmaceutical education because of ChatGPT (Generative Pre-trained Transformer). Through the use of AI technology, ChatGPT provides adaptive tutoring that enables students to advance at their own speed and receive individualised guidance. Their understanding is improved, and it also encourages a more intense level of engagement. Methods: This study discuss how ChatGPT is very important in enhancing inclusion and accessibility in pharmaceutical education. It explore the incorporation of virtual simulations and practical training fills the gap between academic understanding and real-world application by giving students practical experience before they reach the workforce. It also addresses the importance of considering ethical issues, such as data privacy, bias correction, and finding the right balance between human engagement and technology when using AI in education. Results: The abstract highlights various studies that demonstrate the effective inclusion of ChatGPT in pharmaceutical education. Numerous studies...
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