Posted by admin on Jul 31, 2023 in |
Background: The unprecedented overuse and illogical prescribing of antibiotics for various illnesses has accelerated the evolution of antibiotic-resistant bacteria, which has contributed to the resurgence of pathogenic strains with strengthened resistance to conventional therapies. Rising resistance has threatened human health and increased the expense of treating diseases, compromising the treatment procedure for a wide range of antibiotics. Microbes are diversifying quickly due to rapid evolution, which makes it difficult to develop management strategies. This favours the use of plant-derived antimicrobials obtained from medicinal plants to treat diseases. Over the last two decades, an abundance of plant-derived antimicrobials with a wide spectrum of activity against numerous pathogens that cause human infections have been discovered via extensive research. There are various compounds with active components that have been found and are marketed. They have great antibacterial power and can be utilised as antibiotic resistance modifiers or antimicrobials. The current study focuses on the characteristics of plant antimicrobials, their mechanisms of action in combating the rise in microbial resistance, and, in particular,...
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Posted by admin on Jul 31, 2023 in |
Polycystic ovarian syndrome (PCOS) is a hyper-androgenic disorder that is associated with ovaries that produce an abnormal amount of androgens, male sex hormones that are usually present in small amounts in 5-10% of women at 18-44 years of age women. The numerous small cysts (fluid-filled sacs) form in ovaries in small undeveloped follicles. The chemical-based drugs induce the ovulatory cycle instead of allowing it to restore its original healthy rhythm. This hormone imbalance causes their body to skip menstrual periods, making it harder for them to get pregnant. Many allopathic medications are used for PCOS but also have some side effects. To overcome the adverse impact of chemicals on the body, herbal formulations are preferred. This study explores the efficacy of herbs as a possible therapeutic agent in preventing and managing polycystic ovary syndrome (PCOS). The benefit of herbal therapy compared to conventional therapy is that herbal therapy is safe with lesser side effects, and the presence of multiple active compounds in medicinal herbs provides a potentiating...
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Posted by admin on Jul 31, 2023 in |
Paederia foetida is one of the lesser-studied plants that has been utilized as food and medicine by several ethnic groups against stomach pain, bowel disease, snake bite, bone fractures burns, or scalding. Scientific research revealed that the plant exhibits extensive pharmacological activity, including antidiarrheal, antibacterial, anti-inflammatory, anti-diabetic, antiemetic, antioxidant and anti-rheumatoid. Based on the online poll results, information was acquired about P. foetida’s transition from traditional use to scientific validation. Moreover, qualitative and quantitative phytochemical analysis of the plant indicates the presence of 36 important chemical constituents such as; methyl-mercaptan, phenolic, high percentage of minerals, urosolic acid, β-sitosterol, oleanolic acid, arachidic acid. The different phytoconstituents of the plant justify the ethno-medicinal and pharmacological application of the plant. In conclusion, the results of this analysis will produce a new, safe, and low-cost therapeutic strategy for identify and isolate novel chemical entities in drug discovery. Additionally, it may aid in separating fresh lead compounds for future clinical study research. This plant could be an excellent source of safe and effective medicinal...
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Posted by admin on Jul 31, 2023 in |
The International Council for Harmonization (ICH) which aims to harmonize, has altered how pharmaceutical regulations are applied and how drugs are being developed. Pharmaceutical companies use analytical techniques to perform research and development and to manage the inputs and outputs of a process. These analytical methods should routinely produce high-quality data to support decisions while controlling the remaining risks and uncertainties. This review article aspects the highlights of analytical procedure validation and development (ICH Q2 (R2) and ICH Q14). Both the guidelines have been produced by one panel of subject-matter experts and are currently accomplishing the crucial ICH landmark of Step 2 publishing for public comment. The ICH brings both regulatory agencies and pharmaceutical industries to discuss the scientific and technical aspects of drug approval. Since its beginning in 1990, ICH has regularly progressed to meet the international challenge of drug development. ICH’s purpose is to promote better peace worldwide to ensure that secure, useful, and elevated medicines are being developed and registered in the most resource-efficient manner possible. The...
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Posted by admin on Jul 31, 2023 in |
Immunity plays an important role in the protection of the human body and provides several beneficial effects on many infectious diseases and also immunity produces hyperactivity which also causes some problems for the human body, so we want to discuss a summarized knowledge about immunity and their important, advantages, disadvantages and effects on the human body. The present review focuses on various therapeutic effects through different disease conditions, such as autoimmune disorders, infectious diseases, and organ transplants. Thus the immune system and immunity are promising parts for the protection of the human body, which has wide importance in beneficial and another impact in therefore much research can be inspired in this...
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