Posted by admin on Jun 30, 2023 in |
Carbon dots are small nanoparticles having a size of less than 10nm. They have distinctive properties such as chemical stability, water solubility, fluorescence emission, easy synthesis, and low toxicity. Because of their special properties, they have been applied in various scientific disciplines. The fluorescence property of Carbon dots enables them for various biomedical applications such as bioimaging, drug delivery, gene delivery, and cancer therapy. Green synthesized fluorescent carbon dots have biomedical applications, especially for imaging and treatment of in-vitro cancer cells. Carbon dots have visible/natural light-activated antibacterial activities. This review discusses the recent advances of carbon dots in the medical field and their...
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Posted by admin on Jun 30, 2023 in |
An inflammatory disorder with an uncertain cause, rheumatoid arthritis (RA), is primarily distinguished by progressive cartilage loss resulting in persistent polyarthritis and joint deformity. Studies indicate that pannus development, which harms the cartilage and the bone, is caused by synoviocyte cellular growth, albeit the exact pathophysiology of the condition has not yet been determined. Recent research further supports free radicals’ significance in the disease’s etiology. In addition to the traditional therapy approaches, including glucocorticoids, disease-modifying antirheumatic medicines, and non-steroidal anti-inflammatory drugs, newer and safer drugs are constantly being sought after because prolonged use of these medications has led to adverse side effects. Through this review, we all have tried to explore different ancient Indian ancient Ayurvedic, Unani and Tibbi, as also some Oriental and Korean herbals for their very own potential for the treatment of...
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Posted by admin on Jun 30, 2023 in |
Drug discovery is a process that aims at identifying a compound therapeutically useful in curing and treating disease. This process involves the identification of candidates, synthesis, characterization, validation, optimization, screening, and assays for therapeutic efficacy. Once a compound has shown its significance in these investigations, it will initiate the drug development process earlier to clinical trials. The new drug development process must continue through several stages to make a safe, effective medicine that has approved all regulatory requirements. One overall theme of our article is that the process is sufficiently long, complex, and expensive, so many biological targets must be considered for every new medicine ultimately approved for clinical use, and new research tools may be needed to investigate each new target. From initial discovery to a marketable medicine is a long, challenging task. It takes about 12 – 15 years from discovery to the approved medication and requires an investment of about USD 1 billion. This article outlines the processes of new drug discovery and...
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Posted by admin on Jun 30, 2023 in |
Despite the considerable advancement in medical sciences and allopathic medicines, the use of complementary and alternative medicines has dramatically increased worldwide. Bacopa monnieri is one of the most important and highly studied medicinal plants that is being used as an ayurvedic or ethnomedicine for thousands of years. It improves intelligence rejuvenation and treats mental illness, fever, a blood disorder, anemia, etc. The main phytoconstituents of B. monnieri have been reported as alkaloids, saponins, flavonoids, and glycosides, including various sterols and potassium salts. The plant possesses multiple pharmacological properties, such as memory enhancer, anti-depressant, anti-inflammatory, antioxidant, gastroprotective, anxiolytic, hepato-protective, anti-cancer, anti-hyperglycemic, antimicrobial, etc. The pharmacological properties of the plant can be attributed to the presence of saponin-bacoside. The formulations of this plant are used for clinical applications by numerous research groups and pharmaceutical companies worldwide, including in Asia, Australia, and the United States of America. Considering the importance of the plant, the present review summarizes the ethnomedicinal and pharmacological activities of B. monnieri, which may help in exploring the untapped...
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Posted by admin on Jun 30, 2023 in |
Ophthalmic drug delivery is greatly onerous for a better remedial response in any type of disease state for instance, conjunctivitis, more commonly published as pinkeye, is an inflammation of the conjunctiva, a clear membrane that envelopes the outmost lamina of the eye and the inside surface of the eyelids. Usually, conjunctivitis is of the following classes depending on their origins of contagion as like (Allergic conjunctivitis, viral conjunctivitis, Bacterial conjunctivitis, and Irritant and Chemical conjunctivitis). It possibly will cause a number of symptoms grounded on their causative reason, for example Itchiness, body aches, sensitiveness to light, uneasiness in the eye, redness of the eye or inward eyelids, discharge as well as tearness. Discharge may give rise to eyelids crusting and stick together while sleeping and swelling of the...
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