Posted by admin on Jul 31, 2025 in |
Introduction: The use of traditional herbal medicines in conjunction with modern pharmaceuticals is a growing trend. However, the concurrent use of these therapies can lead to significant pharmacological interactions affecting drug metabolism, efficacy and safety. Objective: This systematic review aims to provide a comprehensive overview of pharmacological interactions between traditional herbal medicines and modern pharmaceuticals, highlighting common interactions, elucidating underlying mechanisms and offering clinical recommendations. Methods: A systematic search was conducted in databases including PubMed, MEDLINE and the Cochrane Library for studies published up to July 2024. The review included clinical trials, observational studies, and reviews that examined interactions between herbal medicines and pharmaceuticals. Data were extracted and assessed for quality using the Cochrane risk-of-bias tool and the Newcastle-Ottawa Scale. Results: Out of 3,245 records identified, 50 studies were included in the qualitative synthesis and 20 studies were included in the quantitative synthesis. Common herb-drug interactions were identified, such as St. John’s Wort with antidepressants and anticoagulants, Ginkgo Biloba with anticoagulants and anticonvulsants, and Ginseng with antidiabetic drugs and...
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Posted by admin on Jul 31, 2025 in |
Micronutrient deficiencies are an important driver of morbidity and mortality associated with non-communicable diseases. According to the World Health Organization, more than two billion individuals are micronutrient deficient worldwide, with India home to over half of them. India needs to actively fight against the severe effects of malnutrition since, despite the nation’s strong economic growth and declining poverty rate a sizeable section of the population still has sub-optimal nutrition. This review primarily focuses on the current situation of micronutrient status in the nation, including driving factors that contribute to micronutrient deficiency, clinical perspective and challenges, role of supplementation, long-term and sustainable strategies to reduce micronutrient deficiency, as well as challenges in adapting the micronutrient supplementation practices as in the developed world by the Indian community. To achieve India’s optimum nutritional status, it is required to identify strategic initiatives to overcome practical challenges and implement the right balance of biofortification, nutritional diversification, and sufficient...
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Posted by admin on Jul 31, 2025 in |
A topical drug delivery system involves applying medication to the skin for therapeutic effects or to treat skin disorders. Traditional gels often struggle to deliver hydrophobic drugs effectively, a challenge that can be overcome with emulgels. Emulgels, which combine emulsions and gels, create a dual-release control system that enhances medication efficacy. This innovation is essential in topical delivery systems, significantly improving bioavailability and patient compliance. Emulgel are widely utilized in numerous cosmetic products and for medical applications such as analgesic, antifungals, anti- inflammatory and anti-acne therapies. These topical administration systems have the major benefit of being able to avoid first-pass metabolism, which increases the active compounds’ bioavailability. Emulgels are non-greasy, thixotropic, and easily spreadable, having beneficial qualities for dermatological uses. They also have a longer shelf life because they are water-soluble, emollient and simple to remove. Emulgels are a noteworthy advancement in the field of topical drug administration because of their translucent and visually pleasant look, which also improve user experience. It is a very productive area of research...
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Posted by admin on Jul 31, 2025 in |
Aquasomes are a highly advanced nanoparticulate transport system in nanotechnology. It is mostly utilized for medication delivery. These carriers are differentiated by their three-layered structure, which includes a solid nanocrystalline core (often calcium phosphate or ceramic diamond), a polyhydroxyoligomeric film, and functional properties. The core is solid mechanical strength and stability, but the carbohydrate covering protects the bioactive compounds from dehydration and denaturation. Aquasomes are typically ranging from 60 to 300nm, making them appropriate for a variety of biomedical applications. One of the key benefits of aquasomes in their capacity to deliver medicines, proteins, peptides and genes to particular locations in the body with high precision. This tailored delivery technology increases medicinal efficacy while minimizing negative effects. Additionally, aquasomes provides delayed and prolonged release of the encapsulated compounds, which improves overall treatment outcomes. Aquasomes have demonstrated great potential for delivering insulin, vaccinations and other medicinal substances. Their biocompatibility and capacity to maintain the stability of sensitive molecules make them an adaptable tool in creation of improved drug delivery...
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Posted by admin on Jul 31, 2025 in |
Background: Capsaicin, a bioactive compound derived from the dried fruit of the Solanaceae family, is widely recognized for its therapeutic potential. Its mechanism of action involves interaction with TRPV1 receptors, leading to analgesic effects and modulation of neurogenic inflammation. Objective: This review explores the therapeutic applications of capsaicin, particularly its role in treating non-allergic rhinitis, neuropathic pain, and inflammatory conditions. It also highlights its potential in preventing pneumonia and cluster headaches. Methods: A comprehensive review of existing clinical studies and randomized controlled trials (RCTs) observational studies, and systematic reviews, Randomised placebo- controlled, double blind study, Clinical case series with pre-post outcome assessment was conducted to evaluate capsaicin’s efficacy, and mechanisms of action. Special emphasis was placed on intranasal formulations and their impact on nasal sensory nerve Fibers. Results: Capsaicin has demonstrated significant benefits in reducing nasal symptoms, improving nasal airflow, and alleviating neuropathic pain. Repeated nasal applications have been shown to provide prolonged relief for idiopathic rhinitis, while intranasal capsaicin has been effective in cluster headache prevention. Studies indicate...
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