Posted by admin on May 31, 2023 in |
A category of illnesses known as neurodevelopmental disorders is predominantly linked to neurodevelopmental dysfunctions. The two most prevalent neurodevelopmental disorders, “Attention Deficit/Hyperactivity Disorders (ADHD)” as well as“Autism Spectrum Disorders (ASD)”, affect both humans and lower-class species like rats, mice and zebra fish. The purpose of this review is to identify the behavioral changes brought on by certain Neurodevelopmental disorders-Risk genes, such as CHD8, SHANK3, LPHN3, SLC6A3, etc., and to summarize their genetic screening and epidemiological researches, which directed various neurodevelopmental disorders in various organisms brought on by the interaction of genetic and environmental factors, as well as their genetic screening, which can be used to identify those diseases in humans by this orthologous gene that are present in humans. The majority of genes linked to neurodevelopment disorders were shown to have an excess of de novo mutations (DNMs), but case-control mutation burden research has not been able to prove their importance. We could identify the behavioral anomalies caused by these genes in different species for the development of neuropsychotic...
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Posted by admin on May 31, 2023 in |
Cardiovascular diseases (CVDs) are related to heart and blood vessel disorders. The changing lifestyles of unhealthy diets, physical inactivity, and tobacco and alcohol consumption have increased the risk factors of heart diseases. A literature search reveals that the rise in risk of CVD’s is higher after a SARS-COV2 infection. Also, CVDs independently are one of the leading cause of death globally. There is hence a need of research of new molecules with improved therapeutics. Herbal medications have been utilized to treat cardiovascular diseases for many years around the world. The advancement of herbal nanotechnology in the field of CVDs has been shown to have astounding benefits over herbal crude drug formulations or herbal extracts, including better solubility, bioavailability, toxicity protection, pharmacological activity augmentation, dose reduction, and stability. This paper discusses the traditional herbal drugs and the herbal formulations, specifically herbal nanoparticles (NPs), for the treatment of CVDs and their...
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Posted by admin on May 31, 2023 in |
The new Covid-19 virus has reported deaths of around 1 million within about half a year. It has also led to high financial and social crises worldwide. Recent research has been performed to identify suitable treatment procedures. Steps have been taken to develop complicated, costly, and time-consuming vaccines. Viruses are highly potential to develop into perilous diseases. Over 165 vaccines were developed, and 45 are under clinical trials. The cost to manufacture and internationally deploy an efficacious COVID-19 vaccine will be vast, and the process will be at risk of politicization. Even though few countries may deploy COVID-19 vaccines based on the safety and immunogenicity information alone, vaccine development aims to obtain direct proof of vaccine efficacy for protection against SARS-CoV-2 infection. In this review, we have focused on the latest developments in COVID-19 and have sought to resolve the process and present development efforts of the vaccine in progress. Furthermore focused on the potential strategies in optimizing the COVID-19...
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Posted by admin on May 31, 2023 in |
Tuberculosis is a very serious infectious disease that can lead to death if the person does not take medicine on time. This disease can be spread easily, but it is not mandatory that tuberculosis bacteria will attack suddenly. Still, when the immunity decreases for other reasons, then it will be an attack on health. Before this century, tuberculosis was known as a non-treated disease, but now most drugs are available for treating and curing tuberculosis. This present review provides an overview of the disease and the treatment of...
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Posted by admin on May 31, 2023 in |
AIM: This review aims to analyze the appropriateness of surgical antimicrobial prophylaxis in obstetrics and gynecology from 2015 to June 2022. Methodology: The review includes interventional, prospective and retrospective observational studies and surveys based on compliance with surgical antibiotic prophylaxis use concerning standard surgical antimicrobial prophylaxis (SAP) guidelines for gynecological and obstetrics surgeries from a web search of PubMed and Google Scholar from the year of 2015 to June 2022. Results: The review describes 33 studies focused on the appropriate usage of surgical prophylactic antibiotics. The majority of the studies revealed excessive and inappropriate use, and the compliance is far below the recommended guidelines, especially in terms of duration which is followed by the selection and time of administration of antibiotics. Conclusion: The majority of the studies analyzed in this review indicated a remarkable rate of inappropriateness, which may contribute to antimicrobial resistance (AMR), which raises the risk of SSI exacerbated by resistant bacteria followed by prolonged hospitalization and increased mortality. There is evidence that pharmacist intervention promotes the...
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